Maitiro ekuvandudza kuchengetwa kwemvura kwehydroxypropyl methylcellulose

Hydroxypropyl methylcellulose ndiyo inonyanya kushandiswa kuwedzera muvhu rakaoma dhaka. Cellulose ether inoita basa rinokosha muvhu rakaoma dhaka. Mushure mekunge cellulose ether mudhaka yanyungudutswa, basa repamusoro rinoita kuti simende isimbiswe Iyo sisitimu inonyatso kugovaniswa, uye cellulose ether, seinodzivirira colloid, "inoputira" zvimedu zvakasimba uye inoita dhizaini yekuzora firimu kunze kwayo. pamusoro, kuita kuti sisitimu yevhu igadzikane uye kuvandudza kuyerera kwedhaka panguva yekusanganisa maitiro ezvivakwa uye kutsetseka kwekuvaka.

Hydroxypropyl methylcellulose HPMC ine yakanakisa kuchengetedza mvura, iyo inogona kudzivirira hunyoro huri mudhaka rakanyorova kubva pakubuda nguva isati yakwana kana kunyudzwa neiyo base layer, kuve nechokwadi chekuti simende yakazara hydrated, nekudaro pakupedzisira kuve nechokwadi chemichina yedhaka, iyo inonyanya kubatsira. kune zvidimbu zvitete Tope uye chigadziko chinopinza kana dhaka rinoiswa pasi pekupisa kwepamusoro uye mamiriro akaoma. Iyo yekuchengeta mvura mhedzisiro yehydroxypropyl methylcellulose ether inogona kushandura nzira yekuvaka yechinyakare uye kugadzirisa kufambira mberi kwekuvaka. Semuenzaniso, kuvaka plastering kunogona kuitwa pamvura-inonwisa substrates pasina pre-wetting.

Iyo viscosity, dosage, ambient tembiricha uye molecular chimiro chehydroxypropyl methylcellulose HPMC ine pesvedzero huru pakuita kwayo kuchengetedza mvura. Pasi pemamiriro akafanana, iyo yakakura viscosity ye cellulose ether, zviri nani kuchengetedza mvura; iyo yakakwira dosage, zviri nani kuchengetedza mvura. Kazhinji, shoma shoma ye cellulose ether inogona kuvandudza zvakanyanya kuchengetwa kwemvura kwedhaka. Apo dhigirii inosvika kune imwe Kana iyo dhigirii yakakwirira, chiyero chekuchengetedza mvura chinowedzera zvishoma nezvishoma; kana tembiricha yakadzikama ichikwira, kuchengetwa kwemvura ye cellulose ether kunowanzo kuderera, asi mamwe akagadziridzwa cellulose ethers anewo kuchengetwa kwemvura kuri nani pasi pemamiriro ekupisa kwepamusoro; cellulose ine dhigirii yakaderera yekutsiva Ether inochengeta mvura zviri nani.

Iro hydroxyl boka pa HPMC molecule uye atomu yeokisijeni pane ether bond ichabatana nemvura molecule kuti iite hydrogen bond, ichishandura mvura yakasununguka mumvura yakasungwa, nokudaro ichiita basa rakanaka mukuchengetedza mvura; mamorekuru emvura uye cellulose Kupindirana pakati peether molecular chains kunoita kuti mamorekuru emvura apinde mukati memaketani makuru e cellulose ether uye ari pasi pemasimba akasimba ekusunga, nokudaro kuumba mvura yakasununguka uye mvura yakakanyiwa, iyo inovandudza kuchengetwa kwemvura yematope; cellulose ether inovandudza kuchengetwa kwemvura yezvichangobva kusanganiswa Izvo rheological properties, porous network structure uye osmotic pressure ye simenti paste kana firimu-kugadzira zvinhu zve cellulose ether zvinodzivisa kupararira kwemvura. Zvisinei, nekuda kwekusagutsikana kwekuchengetedza mvura kwezvino cellulose ether, dhaka rine kusabatana kwakashata uye kusashanda zvakanaka kwekuvaka, uye dhaka rinowanzoputika, kuputika uye kudonha mushure mekuvakwa.