Hydroxypropylmethylcellulose (HPMC) is cellulose ether inoshandiswa zvakanyanya mumaindasitiri akati wandei akadai semishonga, zvizorwa, chikafu, uye kuvaka. Nekuda kwekusiyana-siyana uye anobatsira zvivakwa, HPMC yave chinhu chakakurumbira musanganiswa mune akasiyana mafomati. Parizvino, kune akati wandei marudzi eHPMCs pamusika, imwe neimwe iine akasiyana zvivakwa uye mashandisirwo.
HPMC ikemikari yakagadziridzwa cellulose polymer inowanikwa nekuita selulosi ine methyl chloride uye propylene oxide. Izvi zvinounza methyl uye hydroxypropyl mapoka mune cellulose chimiro, ichigadzira mvura-inonyungudika, isiri-ionic uye yakakwirira-inoshanda polymer. Nekudaro, marudzi akasiyana eHPMC ane madhigirii akasiyana ekutsiva (DS) emamethyl uye hydroxypropyl mapoka, ayo anotarisisa iwo emuviri nemakemikari zvimiro.
Kazhinji, zvigadzirwa zveHPMC zvinoiswa muzvikamu zvinoenderana neviscosity uye DS kukosha. Viscosity chinhu chakakosha cheHPMC sezvo ichikanganisa kunyungudika kwechigadzirwa, kugona kugadzira firimu uye kugona kukora. Kune rimwe divi, kukosha kweDS kunotarisa dhigirii repolymer substitution uye nekudaro dhigirii re hydrophobicity yemhando yeHPMC. Naizvozvo, marudzi akasiyana eHPMC anotorwa kuburikidza nekusiyana muviscosity yavo uye DS kukosha. Pazasi pane akajairika marudzi eHPMC uye kuti akasiyana sei.
1. Ordinary giredhi HPMC
Common giredhi HPMC ine methyl DS kubva 0.8 kusvika 2.0 uye hydroxypropyl DS kubva 0.05 kusvika 0.3. Rudzi urwu rweHPMC runowanikwa mune dzakasiyana siyana dze viscosity mamakisi kubva pa3cps kusvika pa200,000cps. Yakajairika giredhi HPMC ine yakanaka solubility mumvura uye inoumba mhinduro dzakajeka, ichiita kuti ive yakakodzera kune akasiyana maapplication mumaindasitiri ezvekudya, emishonga uye ekuzora. MaHPMC akadaro anowanzo shandiswa semafirimu evagadziri, makobvu, emulsifiers uye zvinosimbisa mukudya uye zvizorwa.
2. Low substitution HPMC
Yakaderera-inotsiva HPMC ine yakaderera dhigirii yemethyl uye hydroxypropyl inotsiva pane yenguva dzose giredhi HPMC. Iyi chaiyo mhando yeHPMC ine methyl DS kubva 0.2 kusvika 1.5 uye hydroxypropyl DS kubva 0.01 kusvika 0.2. Low substitution HPMC zvigadzirwa zvine yakaderera viscosity, kazhinji pakati 3-400cps, uye anonyanya kurwisa munyu uye enzymes. Izvi zvivakwa zvinogadzira yakaderera-inotsiva HPMC yakakodzera kune zvigadzirwa zvekudya zvakaita semukaka, kubheka uye zvigadzirwa zvenyama. Pamusoro pezvo, yakaderera-inotsiva HPMC inoshandiswawo sebhainda, disintegrant uye piritsi rekuisa mumiririri muindasitiri yemishonga.
3. High kutsiva HPMC
High degree of substitution HPMC ine dhigirii repamusoro remethyl uye hydroxypropyl inotsiva pane yakajairika giredhi HPMC. Mhando iyi yeHPMC ine methyl DS inotangira pa1.5 kusvika 2.5 uye hydroxypropyl DS inotangira pa0.1 kusvika 0.5. Zvigadzirwa zveHPMC zvakatsiviwa zvakanyanya zvine viscosity yepamusoro, kubva pa100,000cps kusvika pa200,000cps, uye zvine simba rekuchengetedza mvura. Izvi zvivakwa zvinoita yakatsiviwa zvakanyanya HPMC yakanakira kushandiswa muchikamu chekuvaka, senge simende-yakavakirwa zvigadzirwa, machira uye zvinonamira. Yakanyanya kutsiva HPMC inoshandiswawo sebinder, thickener uye kuburitsa mumiririri muindasitiri yemishonga.
4. Methoxy-Ethoxy HPMC
Methoxy-Ethoxy HPMC imhando yakanyatsogadzirwa yeHPMC ine dhigirii repamusoro rekutsiva ethoxy. Mapoka ethoxy anowedzera hydrophobicity yeHPMC, ichiita kuti isanyungudika mumvura kupfuura yegiredhi HPMC. Iine methyl DS kubva 1.5 kusvika 2.5 uye ethoxy DS kubva 0.4 kusvika 1.2, methoxy-ethoxy HPMC yakanakira kushandiswa mumafuta-based zvigadzirwa senge zvizorwa, pendi uye machira. Rudzi urwu rweHPMC runoumba firimu rakagadzikana uye rakafanana rinopa kupera kwakatsetseka, kupenya kune yekupedzisira chigadzirwa.
5. Granular HPMC
Granular HPMC imhando yeHPMC ine diki diki saizi, kazhinji pakati pe100-200 microns. Granular HPMC inoshandiswa muindasitiri yemishonga sepiritsi binder, disintegrant uye inosimudzira kuburitsa mumiririri. Iyo diki diki saizi yeHPMC zvimedu inobvumira kugovaniswa kwezvisanganiswa, zvichikonzera chigadzirwa chakafanana uye chakavimbika. Granular HPMC ine methyl DS inotangira pa0.7 kusvika 1.6 uye hydroxypropyl DS inotangira pa0.1 kusvika 0.3.
Hydroxypropylmethylcellulose (HPMC) i polymer inoshanda yakawanda ine huwandu hwakawanda hwekushandisa mumaindasitiri akasiyana. Mhando dzeHPMC dzakarongedzerwa zvinoenderana neviscosity uye DS kukosha, iyo inotarisisa yavo yemuviri nemakemikari zvimiro. Regular giredhi HPMC, low substitution HPMC, high substitution HPMC, methoxyethoxy HPMC uye granular HPMC ndiwo anonyanya kuzivikanwa marudzi eHPMC. Kunzwisisa mutsauko uripo pakati pemhando idzi kunobvumira vanogadzira kushandisa mukana wakazara weHPMCs kugadzira mhando yepamusoro uye ine simba yekupedzisira zvigadzirwa.
Nguva yekutumira: Sep-06-2023