Zvinhu zvinokanganisa viscosity yehydroxypropyl methylcellulose

Hydroxyl methyl cellulose (HPMC) ipolymer inoshandiswa zvakanyanya mumishonga, zvizorwa, chikafu uye mamwe maindasitiri. Yayo yakasarudzika maficha, akadai seyakakwira viscosity, yakanaka mvura-inonyungudika uye membrane kugadzira kugona, zvichiita kuti ive chinhu chakakosha mumhando dzakasiyana siyana. Iyo viscosity ndicho chinhu chakakosha cheHPMC mukushandisa kwayo. HPMC's viscosity inokanganiswa nezvinhu zvakasiyana, senge kusungirira, tembiricha, pH, uye uremu hwemamorekuru. Kunzwisisa zvinhu zvinokanganisa HPMC viscosity kwakakosha pakugadzirisa. Ichi chinyorwa chinokurukura zvinhu zvinokanganisa viscosity yehydroxylopyl methyl cellulose.

Tarisa pane

Iko kusungirirwa kweHPMC ndechimwe chezvinhu zvakakosha zvinokanganisa viscosity yayo. Iyo viscosity yeHPMC mhinduro inowedzera nekuwedzera kwekunzwa. Panzvimbo yakaderera, iyo HPMC polymer cheni yakapararira zvakanyanya musolvent, saka viscosity yakaderera. Nekudaro, padanho repamusoro, iyo polymer cheni inowanzo dyidzana, zvichikonzera kukwirisa viscosity. Naizvozvo, viscosity yeHPMC inoenderana nekusangana kwepolymer. Iko kusungirirwa kunokanganisa zvakare HPMC's gelization maitiro. High-concentration HPMC inogona kuumba gel, iyo inonyanya kukosha mumhizha yemishonga uye yezvokudya.

tembiricha

Tembiricha chimwe chinhu chakakosha chinokanganisa viscosity yehydroxylopenyl cellulose. HPMC's viscosity inoderera nekuwedzera kwekushisa. Iyo HPMC polymer cheni inova yakawanda kuyerera pane yakakwirira tembiricha, zvichikonzera yakaderera viscosity. Kana ichienzaniswa neyakagadziriswa mhinduro, mhedzisiro yekushisa paHPMC viscosity iri pachena mune yakaderera yekugadzirisa mhinduro. Kuwedzera kwekushisa kuchakanganisawo kunyungudika kweHPMC. Pakupisa kwepamusoro, kunyungudika kweHPMC kunodzikira, zvichikonzera kudzikira kweviscosity kunokonzerwa nekudzikira kwekusungirirwa kweketani.

pH

Iyo pH yeHPMC mhinduro ndechimwe chinhu chakakosha chinokanganisa viscosity yayo. HPMC i polima ine acidic isina simba, ine PKA inosvika 3.5. Naizvozvo, iyo viscosity yeHPMC mhinduro inonzwa kune pH yemhinduro. Pasi pe pH kukosha kwepamusoro kupfuura PKA, boka remunyu recarboxylic acid repolymer rakange rakaita protonization, izvo zvakaita kuti kunyungudika kweHPMC kuwedzere, uye viscosity yakaderedzwa nekuda kwekuderera kwehydrogen bond ye molecular interconsiscence. Pasi pe pH kukosha pasi pePKA, boka re carboxylic acid repolymer rakanga rakakura, izvo zvakakonzera kunyungudika kwakaderera uye kutaridzika kwepamusoro kwakakonzerwa nekuwedzera kwehydrogen bond. Naizvozvo, iyo yakanakisa pH kukosha kweiyo HPMC mhinduro inotsamira pane inotarisirwa application.

Molecular uremu

HPMC's molecular uremu chimwe chinhu chakakosha chinokanganisa viscosity yayo. HPMC i polymer polymer. Sezvo huremu hwepolymer hunowedzera, viscosity yeHPMC mhinduro ichawedzera. Izvi zvinodaro nekuti iyo yakakwira molecular uremu HPMC cheni inobatwa zvakanyanya, zvichikonzera kuwedzera viscosity. Iyo molecular huremu hwepolymer inokanganisawo HPMC gelization. HPMC polymer inonyanya kuumba gels pane yakaderera molecular huremu mapolymer.

Munyu

Kuwedzera munyu kune HPMC mhinduro inogona kukanganisa zvakanyanya viscosity yayo. Munyu unokanganisa simba reion reiyo HPMC mhinduro, inoshandura kupindirana kwemapolymers. Kazhinji, kuwedzera munyu kune HPMC mhinduro kuchaita kuti viscosity ideredze. Izvi zvinodaro nekuti iyo ion simba remhinduro inodzikira pakati pesimba remamorekuru pakati peHPMC polymer cheni, nekudaro ichidzikisa kudzikiswa kweketani entanglement, saka viscosity inoderedzwa. Mhedzisiro yemunyu pane viscosity yeHPMC mhinduro inoenderana nerudzi uye kuiswa kwemunyu.

mukupedzisa

Iyo viscosity yehydroxydal cibolin ndiyo yakakosha parameter inokanganisa mashandisirwo ayo mumaindasitiri akasiyana. Zvinhu zvinokanganisa HPMC viscosity zvinosanganisira kutarisisa, tembiricha, pH, uremu hwemamorekuru uye munyu. Kunzwisisa zvinhu izvi paHPMC viscosity kwakakosha kukwirisa kushandiswa kwayo mukushandisa kwakasiyana. Iyo HPMC mhinduro inogona kugadziridzwa nenzira kwayo kuti iwane viscosity inodiwa iyo yakananga.