Hydroxypropylmethylcellulose (HPMC) inowanzo shandiswa mumaindasitiri emishonga uye ezvekudya. Iyo polymer inonyungudika nemvura inowanikwa nemakemikari ekugadzirisa cellulose. HPMC ine zvinhu zvakasiyana-siyana zvakadai sekugadzira firimu, kukora uye kusunga, izvo zvinoita kuti ive chinhu chakakosha mune zvakasiyana-siyana zvekushandisa.
Chimwe chezvinhu zvakakosha zveHPMC kugona kwayo kugadzira firimu. HPMC inoumba firimu yakagadzikana kana yasangana nemvura, iyo inofambisa kugadzirwa kwemapiritsi uye capsules. Iyo firimu-inogadzira zvimiro zveHPMC inovimbisa kuburitswa kwezvinodhaka pamwero unodzorwa, zvichiita kuti ive yakanaka kune inodzorwa-kuburitswa maumbirwo. Uye zvakare, iyo firimu-inogadzira zvimiro zveHPMC inodzivirira kuparara kwezvinodhaka kubva kune zvakatipoteredza zvinhu zvakaita semwando uye oxygen.
Chimwe chinhu chakakosha cheHPMC kugona kwayo kukora. HPMC ine kugona kuwedzera viscosity yezvinwiwa nekusimudzira kumisa uye emulsifying zvivakwa. Ichi chivakwa chinoita kuti chive chinhu chakakosha mukudya kwakasiyana-siyana kunoshanda senge sosi, madhirezi uye zvigadzirwa zvekubheka.
Saizvozvovo, HPMC ine inoshamisa inosunga simba, iyo yakakosha pakumanikidza piritsi uye granulation. Iyo inonamira zvimiro zveHPMC inovimbisa kuti piritsi racho harityoke nyore uye mushonga unoburitswa panzvimbo yaunoda kuita. Iyi pfuma yeHPMC inoshandiswawo mukugadzirwa kwemapiritsi anoparadza nemuromo, apo inobata sebhainda uye inowedzera kuparara uye kuparara kwemushonga.
Zvimiro zveHPMC zvinoita kuti ive chinhu chakakosha mukushandisa kwakasiyana, asi kunaka kwayo uye kuita kwayo kunofanirwa kuongororwa kuti ive nechokwadi chekuchengetedzwa kwechigadzirwa uye kushanda kwayo. Matanho ekudzora emhando yeHPMC anosanganisira kuyedzwa kweakasiyana emuviri nemakemikari zvimiro senge particle size, viscosity uye hunyoro hwemukati.
Particle saizi yekuongorora yakakosha pakuonekwa kweHPMCs uye inowanzoitwa uchishandisa laser diffraction. Iyo particle size yeHPMC inosarudza solubility yayo uye homogeneity yechigadzirwa chekupedzisira. Viscosity kuyerwa ndeimwe yakakosha yemhando parameter yeHPMC uye inowanzoitwa uchishandisa viscometer. Viscosity zviyero zvinovimbisa kuti HPMC ine ukobvu hunodiwa kuti ishande nemazvo mukushandisa kwayo kwainoda.
Kuongororwa kwehunyoro hwemukati kwakakoshawo pakutonga kwemhando yeHPMC. Hunyoro hunokanganisa kugadzikana, kunyungudika, uye viscosity yeHPMC uye inogona kutungamirira mukuparara kwezvinodhaka. Hunyoro hwehuwandu hweHPMC hwakatemwa neKarl Fischer titration.
Muchidimbu, hydroxypropyl methylcellulose chinhu chakakosha chinobatsira mumaindasitiri emishonga uye ezvekudya nekuda kwekugadzira firimu, kukora uye kusunga zvinhu. Hunhu hweHPMC hwakakosha kuona kuchengetedzeka uye kushanda zvakanaka kwechigadzirwa, uye nhanho dzekudzora mhando senge particle size analysis, viscosity kuyerwa, uye hunyoro hwehunyoro hunofanirwa kuitwa. Nematanho akakodzera ekudzora emhando, HPMC chinhu chakachengeteka uye chinoshanda mumhando dzakasiyana dzekushandisa.
Nguva yekutumira: Aug-09-2023