Ni ubuhe bwoko bwa polymer HPMC?

HPMC, cyangwa hydroxypropyl methylcellulose, ni ubwoko bwa polymer ishingiye kuri selile ikoreshwa cyane mu nganda zimiti, ibiryo, n’inganda zita ku muntu. Cellulose ni polymer karemano iboneka mu bimera kandi ni ibinyabuzima byinshi ku isi. Numurongo wa polymer ugizwe na glucose monomers uhujwe na β (1 → 4) glycosidic.

HPMC ikorwa muburyo bwo guhindura selile hamwe na methyl cyangwa hydroxypropyl. Ihinduka rirashobora gukorwa mugukora selile hamwe na reagent ikwiye imbere ya catisale ya aside. Imyitwarire hagati ya selile na methyl chloride cyangwa methyl bromide itanga methylcellulose, mugihe reaction iri hagati ya selile na protilene oxyde itanga hydroxypropyl selile. HPMC ikorwa muguhuza ibyo bitekerezo byombi kugirango itangire methyl na hydroxypropyl mumatsinda ya selile.

Polimeri yavuyemo ifite imiterere igoye ishobora gutandukana bitewe nurwego rwo gusimbuza (DS) ya methyl na hydroxypropyl. DS bivuga impuzandengo y'amatsinda ya hydroxyl yasimbuwe kuri anhydroglucose igice cyumugongo wa selile. Mubisanzwe, HPMC ifite DS ya 1.2 kugeza 2,5 kumatsinda ya methyl na 0.1 kugeza 0.3 kumatsinda ya hydroxypropyl. Imiterere ya HPMC irarushijeho kuba ingorabahizi kubera ko methyl na hydroxypropyl matsinda bishobora gukwirakwizwa ku buryo butemewe ku mugongo wa selile, bikavamo polymer itandukanye kandi ifite ibintu bitandukanye.

HPMC ni polymer yamazi ashonga ikora ibintu bisa na gel iyo bihinduwe. Imiterere ya gelation ya HPMC iterwa nibintu byinshi, harimo DS, uburemere bwa molekile, hamwe nubunini bwa polymer. Mubisanzwe, HPMC ikora gel ihamye cyane murwego rwo hejuru kandi hamwe nagaciro ka DS. Mubyongeyeho, imiterere ya gelation ya HPMC irashobora guterwa na pH, imbaraga za ionic, nubushyuhe bwumuti.

Imiterere yihariye ya HPMC ituma iba ingirakamaro mubintu byinshi. Mu nganda zimiti, HPMC ikoreshwa nkibikoresho bihuza, bidahwitse, hamwe nogukora firime mubinini na capsules. Irashobora kandi gukoreshwa muguhindura igipimo cyo kurekura ibiyobyabwenge bivuye kumpapuro. Mu nganda zibiribwa, HPMC ikoreshwa nkibyimbye, stabilisateur, na emulifier. Bikunze gukoreshwa mubiribwa birimo amavuta make cyangwa yagabanijwe-karori kugirango bigane imiterere hamwe numunwa wibiryo byamavuta menshi. Mu nganda zita ku muntu ku giti cye, HPMC ikoreshwa nk'umubyimba, ukora firime, na emulifier muri shampo, amavuta yo kwisiga, n'ibindi bicuruzwa.

Mu gusoza, HPMC ni polymer ishingiye kuri selile ikorwa no guhindura imiti ya selile hamwe na methyl na hydroxypropyl. Polimeri yavuyemo ni amazi-ashonga kandi afite imiterere igoye ishobora gutandukana bitewe nurwego rwo gusimbuza no gukwirakwiza amatsinda ya methyl na hydroxypropyl. HPMC ni polymer itandukanye ifite porogaramu nyinshi mubikorwa bya farumasi, ibiryo, ninganda zita kubantu.