Ni ubuhe buryo bwo gukora HPMC?

Ipamba itunganijwe - gufungura - alkalisation - etherification - kutabogama - gutandukana - gukaraba - gutandukana - kumisha - kumenagura - gupakira - kurangiza ibicuruzwa bya HPMC: Ipamba itunganijwe irakingurwa kugirango ikureho ibyuma hanyuma irajanjagurwa. Ipamba yatunganijwe neza iri muburyo bwa poro, hamwe nuduce duto twa mesh 80 hamwe no kohereza 100%. Bitabaye ibyo, biroroshye guhuriza hamwe mugihe cya reaction no kugabanya imikorere ya etherification.

Alkalisation: Ongeramo ifu yifu yatunganijwe nyuma yo gufungura ipamba kumashanyarazi ya inert, hanyuma uyikoreshe hamwe na alkali namazi yoroshye kugirango ubyimba umusego w ipamba itunganijwe kugirango byorohereze kwinjiza molekile ya etherification no kunoza uburinganire bwa reaction ya etherification. Alkali ikoreshwa mu gusya ni hydroxide y'icyuma cyangwa alkali kama. Ingano ya alkali yongeweho (kubwinshi, kimwe hepfo) irikubye inshuro 0.1-0,6 iy'ipamba itunganijwe, ubwinshi bwamazi yoroshye yongewemo ni 0.3-1.0 ugereranije nipamba inoze; umusemburo wa inert ni uruvange rwa alcool na hydrocarubone, kandi ingano ya inert solvent yiyongereyeho inshuro 0.3-1.0 z'ipamba inoze. Inshuro 7 -15 zibyo: Inert solvent irashobora kandi kuba inzoga hamwe na atome ya karubone 3-5 (nka alcool, propanol), acetone. Irashobora kandi kuba hydrocarbone ya alifatique na hydrocarbone nziza; ubushyuhe bugomba kugenzurwa muri 0-35 ° C mugihe cya alkalisation; igihe cya alkalisation ni nka 1h. Guhindura ubushyuhe nigihe birashobora kugenwa ukurikije ibikoresho nibicuruzwa bisabwa.

Etherification: Nyuma yo kuvura alkalisation, mubihe bya vacuum, agent ya etherification yongewe kuri etherification, naho agent ya etherification ni propylene oxyde. Kugirango ugabanye ikoreshwa rya agent ya etherification, mugihe cya etherification, agent ya etherification yongewemo inshuro ebyiri, umubare wongeyeho bwa mbere wikubye inshuro 1-3.5 ugereranije nipamba itunganijwe, kandi umubare wibyongeweho byombi ni 1.5 Inshuro 4 z'ipamba inoze. ibihe. Nyuma yo kongeramo imiti ya etherifingi kunshuro yambere, koga kuri ≤30 ° C kuri 45min-90min, hanyuma uzamure ubushyuhe kuri 50-100 ° C kugirango etherifike ya 1-5h, hanyuma ukonje kugeza kuri ≤30 ° C, ubugira kabiri kongeramo etherification ikurura, gukurura ni 30-120min, hanyuma bigashyuha? ? ? Kora etherification, igihe ni 1-4h, muriki gihe, ipamba itunganijwe neza ikorana na agent ya etherification kugirango itange HYDROXYPROPYL METHYLCELLULOSE HPMC.

Kumenagura no gupakira: kumenagura no gushungura ibicuruzwa byumye byavumbuwe muri iki gihe, ingano yubunini bwibicuruzwa bya HPMC byavumbuwe nyuma yo kumenagura no gushungura ni mesh 40 naho kohereza ni 10096, cyangwa ukurikije ibyo abakoresha bakeneye. Noneho funga HPMC.