Ni ubuhe buryo bwo gushonga bwa HPMC?

Hydroxypropyl methylcellulose (HPMC) ni igice cya sintetike, amazi-elegitoronike polymer ikomoka kuri selile. Ikoreshwa cyane mu nganda zitandukanye, zirimo imiti, ibiryo, ubwubatsi, no kwisiga, kubera imiterere yihariye nko kubyimba, guhambira, gukora firime, no gutuza. Ariko, ni ngombwa kumenya ko HPMC idafite aho ishonga kuko idahura nukuri gushonga nkibikoresho bya kristu. Ahubwo, ikora inzira yo kwangirika yubushyuhe iyo ishyushye.

1. Ibyiza bya HPMC:
HPMC ni ifu yera-yera-ifu idafite impumuro nziza, ishonga mumazi hamwe na solge nyinshi. Imiterere yacyo iratandukanye bitewe nurwego rwo gusimbuza (DS), uburemere bwa molekile, no gukwirakwiza ingano. Muri rusange, irerekana ibintu bikurikira:

Kamere itari ionic: HPMC ntabwo itwara amashanyarazi yose mugukemura, bigatuma ihuza nibindi bikoresho byinshi.
Gukora firime: HPMC irashobora gukora firime zisobanutse, zoroshye iyo zumye, zisanga porogaramu muri coatings, firime, hamwe na dosiye igenzurwa-irekurwa muri farumasi.
Umuti wibyibushye: Itanga viscosity kubisubizo, ikagira akamaro mubicuruzwa byibiribwa, kwisiga, hamwe na farumasi.
Hydrophilic: HPMC ifitanye isano n’amazi, igira uruhare mu gukemura no gukora firime.

2. Synthesis ya HPMC:
HPMC ikomatanyirizwa hamwe nuruhererekane rwimiti irimo selile, okiside ya propylene, na methyl chloride. Inzira ikubiyemo etherifike ya selile hamwe na okiside ya propylene ikurikirwa na methylation hamwe na methyl chloride. Urwego rwo gusimbuza (DS) rwamatsinda ya hydroxypropyl na mikorerexy irashobora kugenzurwa kugirango ihuze imitungo ya HPMC yavuyemo.

3. Porogaramu ya HPMC:
Inganda zikoreshwa mu bya farumasi: HPMC ikoreshwa cyane nkibintu byoroshye mu miti yimiti, harimo ibinini, capsules, ibisubizo byamaso, hamwe na dosiye igenzurwa.
Inganda zibiribwa: Zikoreshwa mubyimbye, stabilisateur, na emulisiferi mubicuruzwa byibiribwa nka sosi, isupu, cream ice, nibintu byokerezwamo imigati.
Inganda zubaka: HPMC yongewe kubicuruzwa bishingiye kuri sima kugirango bitezimbere imikorere, gufata amazi, hamwe no gufatira hamwe. Irakoreshwa kandi mumatafari ya tile, minisiteri, na render.
Inganda zo kwisiga: HPMC ikoreshwa muburyo butandukanye bwo kwisiga nka cream, amavuta yo kwisiga, na shampo kugirango bibyibushye kandi bihamye.

4. Imyitwarire yubushyuhe ya HPMC:
Nkuko byavuzwe haruguru, HPMC ntabwo ifite aho ishonga bitewe na kamere yayo ya amorphous. Ahubwo, ihura nubushyuhe bwumuriro iyo ishyushye. Igikorwa cyo kwangirika kirimo gucamo imiti ya chimique mumurongo wa polymer, biganisha kumikorere yibicuruzwa byangirika.

Ubushyuhe bwo kwangirika bwa HPMC bushingiye ku bintu byinshi, birimo uburemere bwa molekile, urugero rwo gusimbuza, ndetse no kuba hari inyongeramusaruro. Ubusanzwe, ubushyuhe bwa HPMC butangira hafi 200 ° C kandi bugatera imbere hamwe n'ubushyuhe bwiyongera. Umwirondoro wo gutesha agaciro urashobora gutandukana cyane bitewe nicyiciro cyihariye cya HPMC nigipimo cyubushyuhe.

Mugihe cyo kwangirika kwubushyuhe, HPMC ikora inzira nyinshi zihuriweho, zirimo umwuma, depolymerisation, no kubora mumatsinda akora. Ibicuruzwa nyamukuru byangirika birimo amazi, dioxyde de carbone, monoxide carbone, methanol, na hydrocarbone zitandukanye.

5. Ubuhanga bwo gusesengura ubushyuhe bwa HPMC:
Imyitwarire yubushyuhe ya HPMC irashobora kwigwa hakoreshejwe uburyo butandukanye bwo gusesengura, harimo:
Isesengura rya Thermogravimetric (TGA): TGA ipima gutakaza ibiro byintangarugero nkigikorwa cyubushyuhe, itanga amakuru kubyerekeranye nubushyuhe bwumuriro hamwe na kinetics yangirika.
Itandukanyirizo rya skaneri ya calorimetrie (DSC): DSC ipima ubushyuhe bwinjira cyangwa buva mucyitegererezo nkigikorwa cyubushyuhe, butuma ibiranga inzibacyuho hamwe nibintu byubushyuhe nko gushonga no kwangirika.
Fourier-transform infrared spectroscopy (FTIR): FTIR irashobora gukoreshwa mugukurikirana ihinduka ryimiti muri HPMC mugihe cyo kwangirika kwubushyuhe mu gusesengura impinduka mumatsinda yimikorere n'imiterere ya molekile.

6. Umwanzuro:
HPMC ni polymer itandukanye kandi ifite uburyo bwinshi bwo gukoresha imiti, ibiryo, ubwubatsi, no kwisiga. Bitandukanye nibikoresho bya kristu, HPMC ntabwo ifite aho ishonga ariko ihura nubushyuhe bwumuriro iyo ishyushye. Ubushyuhe bwo kwangirika buterwa nibintu bitandukanye kandi mubisanzwe bitangira hafi 200 ° C. Gusobanukirwa imyitwarire yubushyuhe ya HPMC ningirakamaro mugutunganya neza no gutunganya inganda zitandukanye.