Hypromellose ni iki?

Hypromellose, izwi kandi nka hydroxypropyl methylcellulose (HPMC), ni polymer synthique ikomoka kuri selile. Nibintu bikoreshwa cyane mubikorwa bitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi. Uru ruganda rwinshi rufite ibintu byihariye bituma bigira agaciro murwego rwo gusaba.

Imiterere yimiti nibyiza:

Hypromellose ni selile ya selile hamwe na formulaire yimiti (C6H7O2 (OH) 3-x (OC3H7) x) n, aho x igereranya urwego rwo gusimbuza hydroxypropyl hamwe nitsinda ryimikorere. Imiterere yacyo igizwe numurongo wumurongo wibice bya glucose, bisa na selile isanzwe, ariko hamwe nitsinda rya hydroxyl ryasimbujwe hydroxypropyl hamwe nitsinda ryimikorere. Uku gusimbuza guhindura imiterere yumubiri na chimique ugereranije na selile.

Hypromellose iraboneka mubyiciro bitandukanye bitewe nubwiza bwayo nuburemere bwa molekile. Ibyiciro bitandukanye bitanga ubunini butandukanye, bugena imikorere yabyo mubikorwa bitandukanye. Indangamanota yo hejuru cyane ikoreshwa mubikoresho bya farumasi nkibibyimba, mugihe amanota yo hasi yubukonje arakenewe mubisabwa nka coatings na adhesives.

Porogaramu:

1. Imiti ya farumasi: Hypromellose ikoreshwa cyane muburyo bwa farumasi bitewe nubusembure bwayo, ibinyabuzima bidahuza, hamwe nimiterere ya firime. Bikunze gukoreshwa nka binder, kubyimbye, firime yahoze, hamwe nogukomeza-gusohora ibintu muri tablet na capsule. Filime ishingiye kuri Hypromellose itanga uburinzi, itezimbere ibiyobyabwenge, kandi igenzura igipimo cyo gusohora ibiyobyabwenge.
2. Imyiteguro ya Ophthalmic: Mubisubizo byamaso no gusiga amavuta ibitonyanga, hypromellose ikora nka moderi ihindura ibibyimba, itanga firime ikingira hejuru ya ocular. Ifasha kugabanya ibimenyetso byamaso yumye mugusiga amavuta no kunoza imikoreshereze yubushuhe.
3. Ibicuruzwa byo mu kanwa: Hypromellose ikoreshwa mubicuruzwa byita kumanwa nka menyo yinyo hamwe no koza umunwa nkibikoresho byibyimbye hamwe na binder. Itezimbere ibicuruzwa, byongera umunwa, kandi bigahindura imiterere.
4. Inganda zibiribwa: Mu nganda zibiribwa, hypromellose ikoreshwa nkibyimbye, emulisiferi, na stabilisateur mubicuruzwa bitandukanye, birimo isosi, imyambarire, hamwe nubutayu. Itezimbere imiterere, irinda syneresis, kandi ikongerera umutekano muke.
5. Amavuta yo kwisiga: Hypromellose iboneka mubicuruzwa byinshi byo kwisiga, birimo amavuta, amavuta yo kwisiga, hamwe nogukora imisatsi, aho ikora nkibibyimbye, emulisiferi, na firime yahoze. Itanga imiterere yoroshye, yongerera ikwirakwizwa, kandi itanga ibintu bitanga amazi.
6. Ibikoresho byubwubatsi: Mubikoresho byubwubatsi nko gusiga amarangi, gutwikira, no gufatira hamwe, hypromellose ikoreshwa nkibintu byiyongera kandi bihindura imvugo. Itezimbere ubwiza, kwihanganira sag, no gukora, byongera imikorere yibi bikoresho.

Ibyingenzi ninyungu:

• Gukora firime: Hypromellose irashobora gukora firime zoroshye kandi zisa iyo zishonge mumazi cyangwa mumashanyarazi. Izi firime zitanga inzitizi, kugumana ubushuhe, no kugenzura ibiyobyabwenge mugukoresha imiti.
• Amazi meza: Hypromellose irashonga mumazi, bigatuma byoroshye kwinjizwa mumazi. Gukemura kwayo kwemerera gukwirakwiza kimwe no kubyimba neza mubicuruzwa bitandukanye.
• Kubyimba no Gelling: Hypromellose yerekana kubyimbye no gutondeka neza, bigatuma igira agaciro muburyo bukenewe aho hagomba kugenzurwa ibibyimba. Itezimbere ibicuruzwa bihamye, imiterere, nibiranga amarangamutima.
• Biocompatibilité: Hypromellose ntabwo ari uburozi, ntibitera uburakari, ndetse nubuzima bwa biologiya, bigatuma bukoreshwa mugukoresha imiti, ibiryo, nibisiga amavuta. Mubisanzwe bizwi nkumutekano (GRAS) ninzego zibishinzwe.
• pH Ihamye: Hypromellose ikomeza imikorere yayo murwego runini rwa pH, bigatuma ihuza na acide, itabogamye, na alkaline. Ihinduka rya pH ryerekana imikorere ihamye mubikorwa bitandukanye.
• Kurekura Kuramba: Muburyo bwa farumasi, hypromellose irashobora gukoreshwa mugucunga irekurwa ryibintu bikora, bigafasha gutanga imiti irambye cyangwa yagutse. Ihindura ibipimo byo gusesa ibiyobyabwenge bishingiye kuri polymer yibanze hamwe nibipimo.

Ibitekerezo bigenga:

Hypromellose igengwa n’inzego zinyuranye, zirimo Ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) n’ikigo cy’ubuvuzi cy’uburayi (EMA). Yashyizwe muri farumasi nka Pharmacopeia yo muri Amerika (USP) na Pharmacopoeia yu Burayi (Ph. Eur.), Irasobanura ubuziranenge bwayo nibisobanuro byo gukoresha imiti.

Mugukoresha ibiryo, hypromellose ifatwa nkumutekano mukoresha mugihe cyagenwe. Inzego zishinzwe kugenzura zishyiraho urwego ntarengwa rwo gukoresha n’ibipimo byera kugirango umutekano wibicuruzwa.

Inzitizi n'imbibi:

Mugihe hypromellose itanga inyungu nyinshi, irerekana kandi imbogamizi nimbogamizi:

• Kamere ya Hygroscopique: Hypromellose ifite imiterere ya hygroscopique, bivuze ko ikurura ubuhehere buturuka ku bidukikije. Ibi birashobora kugira ingaruka kumitekerereze no gutembera kwifu yifu kandi birashobora gusaba kubika neza no gufata neza.
• Ubushyuhe bukabije: Ubukonje bwibisubizo bya hypromellose birashobora guterwa nubushyuhe, hamwe nubushyuhe bwinshi butera kugabanuka kwijimye. Ubu bushyuhe bukwiye gusuzumwa mugihe cyo gutegura no gutunganya.
• Ibibazo byo guhuza: Hypromellose irashobora gukorana nibintu bimwe na bimwe cyangwa ibiyikubiyemo muburyo bwo gukora, bigira ingaruka kumikorere cyangwa gutuza. Inyigisho zijyanye no guhuza akenshi zikorwa kugirango harebwe imikoranire ishobora no kunonosorwa.
• Inzitizi zo gutunganya: Gutegura hamwe na hypromellose birashobora gusaba ibikoresho kabuhariwe hamwe nubuhanga bwo gutunganya, cyane cyane mubikorwa bya farumasi aho kugenzura neza ububobere nibintu bya firime ari ngombwa.

Ibitekerezo by'ejo hazaza:

Mugihe inganda zikomeje gushakisha ibintu bifite umutekano, bikora neza, kandi birambye, ibyifuzo bya hypromellose biteganijwe kwiyongera. Ubushakashatsi burimo gukorwa bugamije kuzamura imiterere yabwo, guteza imbere ibikorwa bishya, no kunoza imikorere.

Iterambere muri chimie ya polymer hamwe nubuhanga bwo gukora birashobora kuganisha kumajyambere ya hypromellose ikomoka hamwe nibintu byihariye bikoreshwa mubikorwa byihariye. Byongeye kandi, imbaraga zo kunoza uburyo bwo kubyaza umusaruro no kugabanya ingaruka z’ibidukikije bizagira uruhare mu ikoreshwa rirambye rya hypromellose mu nganda zitandukanye.

hypromelloseni polymer itandukanye hamwe nibisabwa cyane muri farumasi, ibiryo, amavuta yo kwisiga, nubwubatsi. Imiterere yihariye, harimo ubushobozi bwo gukora firime, gukemura amazi, hamwe na biocompatibilité, bituma iba ingenzi muburyo butandukanye. Mugihe ibibazo bihari, ubushakashatsi burimo gukorwa no guhanga udushya birasezeranya kurushaho kwagura akamaro ningirakamaro bya hypromellose mumyaka iri imbere.