Hydroxypropyl methyl selulose ni iki?

Hydroxypropyl methylcellulose(HPMC) ni polymer yubukorikori ikoreshwa cyane mubikorwa bitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi. Nubwoko bwa selile ya selile ikorwa no guhindura imiti ya selile naturel, ikaba karubone nziza iboneka mubihingwa. HPMC ni amazi-ashonga, atagira impumuro nziza, kandi adafite uburyohe bufite ibintu byinshi bituma bigira akamaro muburyo butandukanye.

HPMC igizwe n'ibice bibiri by'ibanze: methyl selulose (MC) na hydroxypropyl selulose (HPC). MC ni selile ikomoka kuri selile iboneka mugukora selile hamwe na sodium hydroxide na methyl chloride. Ubu buryo butuma hiyongeraho amatsinda ya methyl mumugongo wa selile, utezimbere gukomera kwamazi. Ku rundi ruhande, HPC ni inkomoko ya selile iboneka mu kuyikora hamwe na oxyde ya propylene. Ubu buryo butuma hongerwaho amatsinda ya hydroxypropyl mumugongo wa selile, bikarushaho kunoza imbaraga zayo mumazi.

Ihuriro ryibi bice byombi muri HPMC ritanga ibintu byihariye nko kongera ubukonje, gufata neza amazi, no kongera imbaraga. Ifite kandi ubushobozi bwo gukora gele iyo ivanze namazi, bigatuma igira akamaro nkibintu byiyongera mubikorwa byinshi.

Gukoresha imiti ya HPMC

Bumwe mu buryo bwibanze bukoreshwa na HPMC ni mu nganda zimiti, aho bukoreshwa nkibintu byoroshye mugutegura imiti itandukanye. Ibicuruzwa ni ibintu byongewe ku bicuruzwa byibiyobyabwenge kugirango byoroherezwe gukora, kuyobora, cyangwa kubyakira. HPMC isanzwe ikoreshwa nka binder, disintegrant, hamwe no kubyimba muburyo bwo gukora ibinini, capsules, nubundi buryo bukomeye bwa dosiye.

Mubisobanuro bya tablet, HPMC ikoreshwa nkigikoresho cyo gufata ibintu bifatika hamwe nibindi bikoresho hamwe. Irakora kandi nka disintegrant, ifasha ibinini kumeneka iyo ihuye namazi cyangwa andi mazi yo mumubiri. HPMC ni ingirakamaro cyane cyane nko gutandukana mubinini bigenewe kumirwa byose, kuko bituma ibinini bisenyuka vuba kandi bikarekura ibintu bikora.

HPMC nayo ikoreshwa nkibikoresho byiyongera muburyo bwa dosiye zamazi nka guhagarikwa, emulisiyo, na geles. Itezimbere ubwiza nuburyo bwimiterere yibi bisobanuro, bishobora kuzamura umutekano wabo no korohereza ubuyobozi. Byongeye kandi, HPMC irashobora gukoreshwa nkumukozi urekura-urekura, utuma imiti irekurwa buhoro buhoro mugihe kinini.

Ibyokurya bya HPMC

Mu nganda zibiribwa, HPMC ikoreshwa nkibintu byiyongera, emulifier, na stabilisateur. Bikunze gukoreshwa mu isosi, kwambara, nibindi bicuruzwa byamazi byamazi kugirango bitezimbere kandi bihamye. HPMC irashobora kandi gukoreshwa mugusimbuza ibinure mubiribwa birimo amavuta make, kuko bishobora kwigana ibinure hamwe numunwa wibinure byamavuta utongeyeho kalori yinyongera.

Amavuta yo kwisiga ya HPMC

HPMC ikoreshwa kandi mu nganda zo kwisiga nkumubyimba, emulifier, na binder. Bikunze gukoreshwa mumavuta yo kwisiga, amavuta, nibindi bicuruzwa byo kwisiga kugirango bitezimbere kandi bihamye. HPMC irashobora kandi gukoreshwa nkigikoresho cyo gukora firime, gishobora kunonosora imiterere n’amazi yo kwisiga.

Ubwubatsi bwa HPMC

Mu nganda zubaka, HPMC ikoreshwa nkumubyimba nogukomeza amazi muri sima na minisiteri. Irashobora kunoza imikorere no guhuzagurika kwibi bisobanuro, bishobora kunoza imikorere no kuramba. HPMC irashobora kandi gukoreshwa nka colloide ikingira, ishobora gukumira igiteranyo cya sima kandi igateza imbere.

Umutekano no kugenzura

Muri rusange HPMC ifatwa nk'umutekano mukoresha mu biribwa, imiti, no kwisiga. Yakozweho ubushakashatsi bwimbitse kubera umutekano n’uburozi bwayo, kandi ishyirwa mu rwego rw’ibintu bidafite uburozi, butari kanseri, ndetse n’ibidafite mutagenike.

Muri Amerika, HPMC igengwa n’ubuyobozi bushinzwe ibiryo n'ibiyobyabwenge (FDA) nk'inyongeramusaruro, na Pharmacopeia yo muri Amerika (USP) nk'ibikoresho bya farumasi. Igengwa kandi nizindi nzego zishinzwe kugenzura ibihugu bitandukanye kwisi.

Nubwo ifite umutekano, HPMC irashobora gutera ibimenyetso byoroheje byo munda nko kubyimba, kubyimba, no gucibwamo kubantu bamwe. Ibi bimenyetso mubisanzwe byoroheje kandi bigarukira, kandi birashobora kwirindwa ukoresheje HPMC mukigereranyo.

Mu gusoza, hydroxypropyl methylcellulose (HPMC) ni polymer zitandukanye kandi zikoreshwa cyane zikoreshwa muburyo bukoreshwa mubikorwa bitandukanye. Imiterere yihariye, nko kwiyongera kwijimye, kunoza gufata neza amazi, hamwe no gufatira hamwe, bituma bigira akamaro nkibintu byongera umubyimba, emulisiferi, stabilisateur, hamwe na binder mu miti yimiti, ibiryo, amavuta yo kwisiga, nubwubatsi. HPMC muri rusange ifatwa nkumutekano kandi igengwa ninzego zinyuranye zishinzwe kugenzura isi.