PH ya HPMC ni iki?

HPMC (Hydroxypropyl Methylcellulose, hydroxypropyl methylcellulose) ni polymer ikemura amazi ikoreshwa cyane mubikorwa bya farumasi, ibiryo ndetse no kwisiga. Ikoreshwa cyane cyane mubyimbye, stabilisateur, emulisiferi, umukozi ukora firime hamwe nubugenzuzi. Kurekura ibikoresho. Ikintu nyamukuru kiranga nuko ishobora gukora igisubizo kiboneye mumazi kandi ikagira umubyimba mwiza hamwe na adhesion.

pH agaciro ka HPMC
HPMC ubwayo ntabwo ifite agaciro ka pH gahamye kuko nibintu bitagira aho bibogamiye cyangwa acide nkeya ya polymer. HPMC ni inkomoko ya selile idasanzwe, ntabwo rero ihindura cyane pH yumuti. Iyo ushonga mumazi, pH yumuti mubisanzwe biterwa na pH yumuti ubwayo aho kuba imiti yibikoresho bya HPMC ubwayo.

Muri rusange, pH ibisubizo bya HPMC bizatandukana bitewe na solve. Mubisanzwe, pH yibisubizo bya HPMC mumazi meza ni hafi ya 6.0 na 8.0. Ubwiza bwamazi aturuka ahantu hatandukanye, kimwe nubunini butandukanye bwa viscosity ya HPMC, birashobora kugira ingaruka nke kuri pH yumuti wanyuma. Niba ari ngombwa gukoresha ibisubizo bya HPMC murwego rwihariye rwa pH, ibi birashobora guhinduka wongeyeho buffers mugihe cyo gutegura.

Ingaruka yumubiri nu miti ya HPMC kuri pH
Kubera ko HPMC ari uruganda rutari ionic kandi rukaba rudafite amatsinda atandukanye muri molekile zayo, ntabwo bigira ingaruka ku buryo butaziguye kuri pH yumuti nka polymers zimwe na zimwe cyangwa anionic. Imyitwarire ya HPMC mugisubizo yibasiwe cyane cyane nubushyuhe, kwibanda, nimbaraga za ionic.

Viscosity and solution stability: Ikintu cyingenzi cya HPMC nubukonje bwacyo, uburemere bwacyo bugena uko yitwara mugisubizo. PH yumuti muke wa HPMC igisubizo gishobora kuba hafi ya pH yamazi ubwayo (mubisanzwe hafi 7.0), mugihe igisubizo cyinshi cyane HPMC gishobora kuba acide nkeya cyangwa alkaline, bitewe nuko hari umwanda cyangwa ibindi byongeweho. mu gisubizo. .

Ingaruka yubushyuhe: Ubukonje bwibisubizo bya HPMC burahinduka hamwe nubushyuhe. Iyo ubushyuhe bwiyongereye, ubukana bwa HPMC bwiyongera kandi ubukonje bukagabanuka. Ihinduka ntirigira ingaruka kuri pH yumuti, ariko irashobora guhindura amazi nuburyo bwimikorere.

pH Guhindura mubikorwa
Mubikorwa bimwe bidasanzwe, nka sisitemu yo kurekura igenzura imiti cyangwa inyongeramusaruro, hashobora kuba ibisabwa byihariye kuri pH. Muri ibi bihe, pH yumuti wa HPMC irashobora guhindurwa wongeyeho aside, shingiro, cyangwa ibisubizo bya buffer. Kurugero, acide citric, buffer fosifate, nibindi birashobora gukoreshwa muguhindura pH yumuti wa HPMC kugirango hamenyekane neza kandi neza nibicuruzwa byanyuma.

Kubikorwa bya HPMC muburyo bwa farumasi, kugenzura pH nibyingenzi cyane kuko gusesa no kurekura ibiyobyabwenge akenshi biterwa na pH yibidukikije. Imiterere itari ionic ya HPMC ituma igaragaza imiterere ihamye yimiti mubidukikije bifite agaciro ka pH bitandukanye, bigatuma ikoreshwa mubinini byo mu kanwa, capsules, imyiteguro y'amaso hamwe na farumasi yimiti.

PH agaciro ka HPMC ubwayo ntabwo ifite agaciro gahamye. PH yayo iterwa cyane na sisitemu yo gukemura no gukemura ikoreshwa. Mubisanzwe, pH yibisubizo bya HPMC mumazi bigera kuri 6.0 kugeza 8.0. Mubikorwa bifatika, niba pH yumuti wa HPMC igomba guhinduka, irashobora guhindurwa wongeyeho buffer cyangwa aside-ishingiro.