Amashanyarazi ya CMC ni iki?

Carboxymethyl selulose (CMC), izwi kandi ku izina rya selile, ni inyongeramusaruro kandi ikoreshwa cyane mu nganda zitandukanye, zirimo ibiryo, imiti, ubuvuzi bwite, hamwe n’inganda zikoreshwa mu nganda. Bikomoka kuri selile, polymer karemano iboneka mubihingwa, binyuze muburyo bwo guhindura imiti. CMC ihabwa agaciro kubintu byihariye, birimo kubyimba, gutuza, hamwe nubushobozi bwo gukora film.

Imiterere yimiti nibyiza:

CMC ikomatanyirizwa mu gukora selile hamwe na aside ya chloroacetike na hydroxide ya sodium. Ihindurwa ryimiti rivamo kwinjiza amatsinda ya carboxymethyl (-CH2-COOH) kumugongo wa selile. Urwego rwo gusimbuza (DS), rwerekana umubare mpuzandengo wamatsinda ya carboxymethyl kuri glucose, igena imiterere yibicuruzwa bya CMC.

CMC iraboneka mubyiciro bitandukanye ukurikije ubwiza bwayo, urwego rwo gusimbuza, nubunini buke. Impamyabumenyi yo hejuru ya DS yerekana imbaraga nyinshi kandi zibyibushye, mugihe amanota yo hasi ya DS atanga ubwuzuzanye bwiza hamwe na solge organique hamwe nuburyo bwiza bwo gukora firime.

Porogaramu:

1. Inganda zikora ibiribwa: CMC isanzwe ikoreshwa munganda zibiribwa nkibibyimbye, stabilisateur, na emulisiferi mubicuruzwa byinshi. Itezimbere ubwiza, ubwiza, hamwe numunwa mukurya ibiryo nka sosi, imyambarire, ibikomoka kumata, ibicuruzwa bitetse, nibinyobwa. CMC irinda kandi ibara rya kirisiti mu butayu bwakonje kandi ikongerera umutekano ibiryo bitunganijwe.

1. Imiti ya farumasi: Mubikorwa bya farumasi, CMC ikora nka binder, disintegrant, na viscosity ihindura ibinini, capsules, guhagarika, namavuta. Yorohereza ibinini bya tablet, iteza ibiyobyabwenge, kandi itanga uburinganire muburyo bwa dosiye. Ihagarikwa rishingiye kuri CMC ritanga ituze ryiza kandi ryorohereza kwiyubaka kumiti.
2. Ibicuruzwa byita ku muntu ku giti cye: CMC iboneka mu kwita ku muntu ku giti cye no kwisiga, harimo umuti w’amenyo, shampoo, amavuta yo kwisiga, hamwe na cream. Ikora nkibyimbye, ihagarika agent, hamwe nububiko bugumana ubuhehere, kuzamura ibicuruzwa, gutuza, no gukora. Mu menyo yinyo, CMC itezimbere kandi ikemeza gukwirakwiza ibintu bifatika.
3. Inganda zikoreshwa mu nganda: CMC ikoreshwa mubikorwa byinshi byinganda, nk'imyenda, imyenda, gukora impapuro, no gucukura peteroli. Mu byuma byangiza, CMC ikora nk'ubutaka buhagarika ubutaka hamwe nubwubatsi bwijimye, kunoza imikorere yisuku no kwirinda ko ubutaka bwongera kugaragara. Mu myenda, CMC ikoreshwa nkigikoresho kinini kandi ikabyimbye kugirango yongere imbaraga zimyenda kandi icapwe.
4. Inganda zikomoka kuri peteroli na gazi: CMC ikoreshwa mugucukura amazi nka viscosifier na agent igenzura igihombo. Ifasha kugumana ubwiza no gutuza mu gucukura ibyondo, kugabanya ubukana no kunoza amavuta mugihe cyo gucukura. CMC irinda kandi gutakaza amazi mumazi yemewe, byongera ubunyangamugayo no gutanga umusaruro.

Ibyingenzi ninyungu:

• Kubyimba: CMC yerekana ibintu byiza cyane byo kubyimba, ikora ibisubizo bibonerana kumitekerereze mike. Itezimbere imiterere nuburinganire bwibicuruzwa, byongera ibyiyumvo byabo nibikorwa.
• Gutuza: CMC ikora nka stabilisateur, ikumira gutandukanya ibyiciro no gukomeza gukwirakwiza ibintu bimwe mubigize. Itezimbere ubuzima bwibicuruzwa kandi ikarinda synereze muri geles na emulisiyo.
• Amazi meza: CMC irashonga cyane mumazi, ikora ibisubizo bisobanutse, bisobanutse. Kwihuta kwayo no gutandukana byoroha kwinjiza mumazi yo mumazi, bitanga ubwiza bumwe nuburyo bwiza.
• Gukora firime: CMC irashobora gukora firime zoroshye kandi zifatanije mugihe zumye, zitanga inzitizi no kugumana ubushuhe. Ikoreshwa mubitambaro, ibifatika, na firime ziribwa kugirango utezimbere imbaraga, gufatana, hamwe nubusugire bwa film.
• Biocompatibilité: CMC isanzwe izwi nkumutekano (GRAS) ninzego zibishinzwe kandi ikoreshwa cyane mubiribwa, imiti, nibicuruzwa byumuntu. Ntabwo ari uburozi, ntibitera uburakari, kandi burashobora kwangirika, bigatuma bukoreshwa mubikorwa bitandukanye.

Ibitekerezo bigenga:

CMC igengwa n’inzego z’ibiribwa n’ibiyobyabwenge ku isi hose, harimo n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), Ikigo cy’Uburayi gishinzwe umutekano w’ibiribwa (EFSA), na komite y’impuguke ihuriweho na FAO / OMS ishinzwe kongeramo ibiribwa (JECFA). Byemewe gukoreshwa nkibiryo byongera ibiryo, imiti yimiti, nibikoresho byo kwisiga mugihe cyagenwe.

Inzego zishinzwe kugenzura zishyiraho ibipimo byera, urwego ntarengwa rwo gukoresha, nibisobanuro ku bicuruzwa bya CMC kugirango umutekano wabo ube mwiza. Kubahiriza aya mabwiriza ningirakamaro kubabikora kugurisha ibicuruzwa birimo CMC byemewe n'amategeko.

Inzitizi n'imbibi:

Mugihe CMC itanga inyungu nyinshi, irerekana kandi imbogamizi zimwe na zimwe:

• pH Ibyiyumvo: CMC irashobora guhinduka pH-biterwa no gukemuka no guhinduka kwijimye, bigira ingaruka kumikorere yabyo muburyo butandukanye. Guhindura muri pH birashobora gusabwa kunoza imikorere yayo mubikorwa byihariye.
• Shear Sensitivity: Ibisubizo bya CMC biragabanuka, bivuze ko ububobere bwabo bugabanuka mugihe cyo guhangayika. Iyi myitwarire ya rheologiya igomba kwitabwaho mugihe cyo kuyitunganya no kuyikemura kugirango ibicuruzwa bigerweho.
• Ibibazo byo guhuza: CMC irashobora gukorana nibintu bimwe na bimwe cyangwa inyongeramusaruro, biganisha ku ngaruka zitifuzwa nko kugabanuka kwijimye cyangwa guhungabana. Kwipimisha guhuza birakenewe kugirango habeho guhuza no kunoza imikorere.
• Kamere ya Hygroscopique: CMC ifite imiterere ya hygroscopique, ikurura ubuhehere buturuka ku bidukikije. Ibi birashobora kugira ingaruka kumitekerereze no gutembera kwifu ya poro kandi birashobora gusaba gupakira no kubika neza.

Ibitekerezo by'ejo hazaza:

Mu gihe inganda zikomeje gushyira imbere iterambere rirambye, umutekano, n’imikorere, biteganijwe ko CMC isabwa kwiyongera. Ubushakashatsi burimo gukorwa bugamije guteza imbere ibikomoka kuri CMC byahinduwe bifite imitungo yongerewe imbaraga mu bikorwa byihariye, ndetse n’uburyo bwangiza ibidukikije hagamijwe kugabanya ingaruka z’ibidukikije.

Iterambere mu ikorana buhanga hamwe nubuhanga bwo gutunganya birashobora kurushaho kwagura ibikorwa byinshi bya CMC mubikorwa bitandukanye. Byongeye kandi, inzego zishinzwe kugenzura ibikorwa zizakomeza gukurikirana no gusuzuma umutekano n’ibikorwa by’ibicuruzwa birimo CMC kugira ngo birinde umuguzi no kubahiriza ibipimo ngenderwaho.

carboxymethyl selulose (CMC) ninyongera yingirakamaro hamwe nibikorwa bitandukanye mubikorwa byinshi. Imiterere yihariye, harimo kubyimba, gutuza, hamwe nubushobozi bwo gukora firime, bituma iba ingenzi mubiribwa, imiti, ubuvuzi bwihariye, hamwe ninganda. Nubwo hari imbogamizi n’imbogamizi, ubushakashatsi bukomeje gukorwa no guhanga udushya byizeza ko bizatera imbere mu ikoranabuhanga rya CMC, bikemura ibibazo by’abaguzi n’inganda ku isi.