Hydroxypropylmethylcellulose (HPMC) ni polymer ikoreshwa cyane iboneka mubicuruzwa bitandukanye birimo kwisiga, imiti, amarangi n'ibiryo. Ikorwa muguhindura selile ikoresheje reaction ya chimique ya propylene oxyde na methyl chloride. HPMC ifite ibintu byinshi byifuzwa, nk'uburozi, kutarakara, ibinyabuzima, ndetse na biocompatible. Imwe mu miterere yihariye ni ubushobozi bwayo bwo guhindura urumuri. Muri iyi ngingo, turasesengura ibintu bitandukanye biganisha kuri HPMCs bigira ingaruka ku bwikorezi bworoshye hamwe nibishobora gukoreshwa muri uyu mutungo.
Kimwe mu bintu byingenzi bigira ingaruka kumirasire ya HPMC ni imiterere ya molekile. HPMC ni polymer ishami rigizwe na selile na methyl hydroxypropyl isubiramo ibice. Uburemere bwa molekuline ya HPMC biterwa nurwego rwasimbuwe (DS), impuzandengo ya hydroxypropyl na methyl matsinda kuri selile. HPMC hamwe na DS yo hejuru ifite hydroxypropyl na methyl matsinda menshi, bikavamo uburemere buke bwa molekile kandi bigira ingaruka zikomeye kumurabyo.
Ikindi kintu cyingenzi kigira ingaruka kumyuka yumucyo ni kwibanda kuri HPMC mugisubizo. Iyo HPMC imaze gushonga mumazi, igisubizo kiboneye kandi kiboneye gishyirwa kumurongo muke. Mugihe kwibanda kwiyongera, igisubizo kiba cyiza cyane kandi itumanaho rigabanuka kubera gutatanya urumuri. Ingano yiyi ngaruka iterwa nuburemere bwa molekuline, DS nubushyuhe bwumuti.
Ikintu cya gatatu kigira ingaruka kumurabyo ni pH yumuti. HPMC ni polymer amphoteric ishobora gukora nka acide idakomeye nishingiro ridakomeye, bitewe na pH yumuti. Kuri pH nkeya, hydroxypropyl na methyl matsinda kuri HPMC ihinduka protonone, bigatuma kugabanuka gukabije no kugabanya urumuri. Kuri pH ndende, umugongo wa selile ya HPMC wangiritse, bigatuma kwiyongera kwinshi no kohereza urumuri.
Ikintu cya kane kigira ingaruka ku kwanduza urumuri ni ukubaho ibindi bikoresho nkumunyu, surfactants hamwe na co-solvents. Izi mvange zirashobora gukorana na HPMC, bigatera impinduka mumiterere ya molekile no gukomera, bityo bikagira ingaruka kumurabyo. Kurugero, kongeramo umunyu birashobora kongera ionic imbaraga zumuti, bikavamo kugabanuka kwinshi no kongera urumuri. Ku rundi ruhande, kuba hari surfactants zirashobora guhindura uburemere bwikibazo cyumuti, bikaviramo kugabanuka kwijimye no kwiyongera kwumucyo.
Umucyo wohereza urumuri rwa HPMC ufite porogaramu zitandukanye. Mu nganda zimiti, HPMC ikoreshwa nkibyimbye, bihambira kandi bidahwitse mubinini na capsules. Ubushobozi bwayo bwo kwanduza urumuri bituma bugira akamaro nkibikoresho byo gutwikira bishobora kurinda ibintu bikora kwangirika kwatewe n’umucyo. Imiterere ikwirakwiza urumuri rwa HPMC nayo ituma iba umukandida ukwiye muri sisitemu yo gutanga ibiyobyabwenge bigenzurwa bisaba kurekura byimazeyo ibintu bikora.
Usibye imiti, imiti itanga urumuri rwa HPMC ikoreshwa no mu nganda y'ibiribwa. HPMC ikoreshwa nkibisimbuza amavuta mubiryo birimo amavuta make na karori nkeya. Ubushobozi bwayo bwo gukora geles nziza kandi ihamye mubisubizo byamazi bituma iba ikintu cyiza kubicuruzwa nko kwambara salade, mayoneze na sosi. Ibintu bikwirakwiza urumuri rwa HPMC birashobora kandi gukoreshwa mugukora igicu mubinyobwa nkumutobe wimbuto n'ibinyobwa bya siporo.
Muri make, hydroxypropylmethylcellulose (HPMC) ni polymer yubukorikori ifite agaciro kubera imiterere yihariye, harimo nubushobozi bwo kwanduza urumuri. Ibintu bigira ingaruka ku ihererekanyabubasha rya HPMC harimo imiterere ya molekile, kwibanda, pH, no kuba hari ibindi bikoresho. Ibikoresho byohereza urumuri rwa HPMC bifite uburyo bwinshi bushobora gukoreshwa mu nganda zimiti n’ibiribwa, harimo gutanga imiti igenzurwa n’ibiribwa birimo amavuta make. Mugihe ubushakashatsi kumiterere ya HPMCs bukomeje, porogaramu nyinshi zishobora kuvumburwa.
Igihe cyo kohereza: Kanama-02-2023