Nibihe bintu nyamukuru byerekana tekinike ya hydroxypropyl methylcellulose (HPMC)?

Hydroxypropylmethylcellulose (HPMC) ni polymer izwi cyane ikoreshwa mu nganda nka farumasi, ubwubatsi, ibiryo no kwita ku muntu ku giti cye. Nuburyo bwahinduwe bwa selile yabonetse mugukora methylcellulose hamwe na okiside ya propylene. HPMC ni umweru cyangwa utari umweru, impumuro nziza, ifu itaryoshye, byoroshye gushonga mumazi, Ethanol nibindi bishishwa kama. Uru rupapuro rugaragaza ibipimo ngenderwaho bya tekiniki bya HPMC.

ububobere

Viscosity nigipimo cyingenzi cya tekiniki ya HPMC, igena imyitwarire yimikorere nogukoresha mubikorwa bitandukanye. HPMC ifite viscosity nyinshi, bivuze ko ifite umubyimba mwinshi, umeze nkubuki. Ubukonje bwa HPMC burashobora guhinduka muguhindura urwego rwo gusimbuza amatsinda ya hydroxyl. Urwego rwo hejuru rwo gusimburana, niko kwiyongera.

Impamyabumenyi yo gusimburwa

Urwego rwo gusimbuza (DS) nikindi kimenyetso cyingenzi cya tekiniki ya HPMC, bivuga umubare wamatsinda ya hydroxyl yasimbuwe nitsinda rya hydroxypropyl nitsinda rya methyl. DS ya HPMC mubusanzwe iri hagati ya 0.1 na 1.7, hamwe na DS yo hejuru yerekana ihinduka ryinshi. DS ya HPMC igira ingaruka ku gukemuka kwayo, ibishishwa hamwe na gel.

uburemere bwa molekile

Uburemere bwa molekuline ya HPMC nabwo ni ingirakamaro yingenzi ya tekiniki igira ingaruka kumiterere yumubiri nubumara nka solubile, viscosity, na gelation. HPMC mubusanzwe ifite uburemere bwa molekuline ya 10,000 kugeza 1.000.000 Daltons, hamwe nuburemere buke bwa molekile bwerekana iminyururu ndende ya polymer. Uburemere bwa molekuline ya HPMC bugira ingaruka kumubyimba wabwo, ubushobozi bwo gukora firime nubushobozi bwo gufata amazi.

Agaciro PH

Agaciro pH ka HPMC nigipimo cyingenzi cya tekiniki kigira ingaruka ku gukemuka kwayo. HPMC irashobora gushonga mubisubizo bya acide na alkaline, ariko ububobere bwayo buri hejuru mubihe bya acide. PH ya HPMC irashobora guhindurwa wongeyeho aside cyangwa base. HPMC mubusanzwe ifite pH hagati ya 4 na 9.

ibirimo ubuhehere

Ibirungo bya HPMC nigipimo cyingenzi cya tekiniki kigira ingaruka kububiko bwacyo no gutunganya imikorere. HPMC ni hygroscopique, bivuze ko ikuramo ubuhehere buturuka mu kirere. Ibirungo bya HPMC bigomba kubikwa munsi ya 7% kugirango bihamye kandi byiza. Ubushuhe bwinshi burashobora gushikana kuri polymer cake, gufatana no kwangirika.

Ibirimo ivu

Ivu rya HPMC nigipimo cyingenzi cya tekiniki kigira ingaruka nziza kandi nziza. Ivu bivuga ibisigazwa bya organic organique bisigaye nyuma ya HPMC. Ivu rya HPMC rigomba kuba munsi ya 7% kugirango ryemeze neza. Ivu ryinshi rishobora kwerekana ko hariho umwanda cyangwa umwanda muri polymer.

Ubushyuhe bwa gelation

Ubushyuhe bwa gel bwa HPMC nigipimo cyingenzi cya tekiniki kigira ingaruka kumikorere ya gel. HPMC irashobora kuza mubushuhe hamwe nubushuhe. Ubushyuhe bwa gelation ya HPMC burashobora guhinduka muguhindura urwego rwo gusimbuza nuburemere bwa molekile. Ubushyuhe bwa HPMC ni 50 kugeza 90 ° C.

mu gusoza

Hydroxypropylmethylcellulose (HPMC) ni polymer ikora cyane hamwe nurwego runini rwibisobanuro. Ibipimo byingenzi bya tekinike ya HPMC birimo ubukonje, urugero rwo gusimbuza, uburemere bwa molekile, agaciro ka pH, ibirimo ubuhehere, ibivu, ubushyuhe bwa gelation, nibindi. Ibi bipimo bya tekiniki bigira ingaruka kumubiri na chimique ya HPMC kandi bikagaragaza imikorere yayo mubikorwa bitandukanye. Kumenya ibi bisobanuro, turashobora guhitamo ubwoko bukwiye bwa HPMC kubisabwa byihariye kandi tukemeza ubuziranenge bwayo.