Nibihe bintu bigira ingaruka ku bwiza bwa HPMC?

kumenyekanisha

Hydroxypropyl methylcellulose (HPMC) ni ether ya selile idafite selile ikoreshwa cyane mu nganda zinyuranye bitewe n’imiterere yayo myiza nko gukemura amazi, imitungo ikora firime, hamwe no gufatira hamwe. Ubushobozi bwayo bwo guhindura ububobere butuma biba byiza mubikorwa byinshi, harimo ibiryo, imiti n amarangi. HPMC ikomoka kuri polymer naturel ya selile isanzwe, ikaba glycosilate kugirango ikore urusobe rwa selile-ogisijeni. Imiterere nubwiza bwa HPMC biterwa nibintu nkuburemere bwa molekile, urugero rwo gusimbuza, kwibanda, ubwoko bwa solvent, pH, ubushyuhe nimbaraga za ionic.

Muri iki kiganiro, tuzaganira ku bintu bigira ingaruka kuri HPMC hamwe nuburyo bukoreshwa.

uburemere bwa molekile

Uburemere bwa molekuline ya HPMC bugena ahanini ubwiza bwayo. Ikigaragara ni uko uburemere bwa molekile burenze, niko biba byiza cyane. Uburemere bwa molekuline ya HPMC buri hagati ya 10 ^ 3 kugeza 10 ^ 6 Da. Mugihe uburemere bwa molekile bwiyongera, umubare wibintu biri hagati yiminyururu ya HPMC nabyo biriyongera, bigatuma kwiyongera kwijimye.

Impamyabumenyi yo gusimburwa

Urwego rwo gusimbuza (DS) rwa HPMC rugena umubare wamatsinda ya hydroxypropyl na methyl mumiterere yayo. HPMC hamwe na DS yo hejuru ni hydrophobique kandi ntishobora gukama amazi kurusha HPMC hamwe na DS yo hepfo. Urwego rwo gusimbuza rugira ingaruka ku gukomera kwa HPMC mu mazi, ari nako bigira ingaruka ku bushobozi bwayo bwo gukora imiyoboro ifatanye no kongera ubwiza.

kwibanda

Kwishyira hamwe nikimwe mubintu bikomeye bigira ingaruka kumyuka ya HPMC. Mubisanzwe, ubwiza bwibisubizo bya HPMC bwiyongera hamwe no kongera ibitekerezo. Iyi myitwarire yitirirwa kwizirika kumurongo wa HPMC murwego rwo hejuru.

Ubwoko bwumuti

Ubwoko bwa solvent bugira uruhare runini mubwiza bwa HPMC. Rimwe na rimwe, HPMC ifite ubukonje bwinshi mu mazi kuruta mu mashanyarazi amwe. Impamvu irashobora guterwa nubusabane butandukanye hagati ya molekile ya solvent na HPMC.

pH

PH yumuti irashobora kugira ingaruka zikomeye kubwiza bwa HPMC. Kuri acide pH, HPMC irashobora gukora hydrogene ihuza umusemburo, bigatuma kwiyongera kwijimye. Byongeye kandi, pH igira ingaruka kurwego rwa ionisation ya hydroxypropyl na methyl, ibyo nabyo bigira ingaruka kumikoranire ya electrostatike na hydrophobique hagati yumunyururu wa HPMC.

ubushyuhe

Ubushyuhe nabwo bugira ingaruka ku bwiza bwa HPMC. Ku bushyuhe bwinshi, molekile ya HPMC ifite umuvuduko mwinshi, bigatuma imikoranire ya intermolecular igabanuka. Iyi myitwarire mubisanzwe itera kugabanuka kwibisubizo. Ibinyuranye na byo bigaragara ku bushyuhe buke. Bitewe no gukomera kwa molekile ya HPMC, ubwiza bwumuti bwiyongera hamwe nubushyuhe bugabanuka.

imbaraga ionic

Imbaraga za Ionic nikindi kintu kigira ingaruka kuri HPMC. Iyi parameter yerekana kwibanda kuri ion mugisubizo. Umunyu nka sodium chloride urashobora kugira ingaruka zikomeye mubwiza bwa HPMC mugutera impinduka mumiterere ya ionisation ya hydroxypropyl na methyl. Ihinduka rihindura imikoranire hagati ya molekile ya HPMC, bityo bikagira ingaruka kumyumvire yumuti.

mu gusoza

Ubukonje bwa HPMC bugira ingaruka kubintu byinshi, birimo uburemere bwa molekile, urugero rwo gusimbuza, kwibanda, ubwoko bwa solvent, pH, ubushyuhe nimbaraga za ionic. Mugihe utegura ibicuruzwa birimo HPMC, nibyingenzi gusuzuma ibi bintu byose kugirango wizere ko ibishishwa byifuzwa bigerwaho. Kunoza neza ibyo bintu bishobora kuvamo gukora ibicuruzwa byiza kandi bihamye byujuje intego yabyo.