Indwara ya hypromellose ni iki?

Hypromellose phthalate (HPMCP) ni ubwoko bwimiti yimiti ikoreshwa mugutegura imiti yo mu kanwa, cyane cyane mugukora ibinini byanditseho enterineti na capsules. Bikomoka kuri selile, ni polymer karemano igizwe nibintu bigize urukuta rw'ibimera. HPMCP ni amazi ashonga, anionic polymer ikunze gukoreshwa nkibikoresho byo gutwika ibintu kubera imiterere myiza ya firime, itajegajega, hamwe no kurwanya amazi yo mu gifu.

HPMCP yatangijwe bwa mbere mu ntangiriro ya za 1970 kandi kuva icyo gihe yahindutse ibikoresho byinshi byinjira mu nda kubera imiterere yihariye. Ikorwa na esterification ya hypromellose hamwe na acide phthalic kandi iraboneka mubyiciro bitandukanye, bitewe nurwego rwa phthalation hamwe nuburemere bwa molekile ya polymer. Ibyiciro bikoreshwa cyane muri HPMCP ni HPMCP-55, HPMCP-50, na HPMCP-HP-55, bifite impamyabumenyi zitandukanye za phthalation kandi bikwiriye gukoreshwa muburyo butandukanye.

Igikorwa nyamukuru cya HPMCP muburyo bwo gufata imiti ni ukurinda ibintu bikora bigize imiti kwangirika kwangiza aside igifu. Iyo ibinini cyangwa capsule irimo HPMCP byinjiye, igifuniko gikomeza kuba cyiza mu gifu kubera pH nkeya, ariko iyo dosiye imaze kugera ku bidukikije byinshi bya alkaline yo mu mara mato, igifuniko gitangira gushonga no kurekura ibintu bifatika. Irekurwa ryatinze rifasha kwemeza ko imiti igezwa aho ikorera kandi ko imikorere yayo itabangamiwe na aside gastric.