Ubukonje, ibirimo, ubushyuhe bwibidukikije hamwe na molekulire ya HPMC bigira uruhare runini mu gufata amazi

Hydroxypropylmethylcellulose (HPMC) ni kimwe mu bikoresho bikoreshwa cyane mu nganda z’imiti n’ibiribwa ndetse n’inganda zubaka. Kimwe mu byiza byingenzi bya HPMC nubushobozi bwayo bwo kugumana amazi, bigatuma biba byiza mubikorwa bitandukanye. Imikorere yo gufata amazi ya HPMC yibasiwe nibintu byinshi, harimo ubukonje, ibirimo, ubushyuhe bwibidukikije hamwe na molekile.

ububobere

Kimwe mu bintu by'ingenzi bigira ingaruka ku mikorere yo gufata amazi ya HPMC ni ubwiza bwayo. Viscosity bivuga ubunini cyangwa kurwanya ibintu bitemba. Kuri HPMC, uko ubukonje buri hejuru, niko amazi agumana.

Ubukonje bukabije HPMC ifite uburemere buke bwa molekile, bivuze ko iminyururu ndende ya polymer. Iminyururu ndende ituma bigora molekile zamazi kunyura mubintu. Ibi bivamo gufata amazi menshi nkuko molekile zamazi zafatiwe muri materix ya polymer, byongera imbaraga rusange muri matrix.

ibirimo

Ikindi kintu kigira ingaruka kumikorere yo gufata amazi ya HPMC nibirimo. HPMC igizwe n'ibice bibiri by'ingenzi bifite urwego rutandukanye rwa hydrophilique, aribyo mikorerexyl na hydroxypropyl. Iyo hydroxypropyl iri hejuru ya HPMC, nubushobozi bwo gufata amazi niko.

Itsinda rya hydroxypropyl muri HPMC rigena imikorere yo gufata amazi. Aya matsinda akurura kandi agumana molekile zamazi, bigatuma HPMC yabyimba. Uku kubyimba bifasha gukora inzitizi itinda kurekura amazi muri HPMC. Ku rundi ruhande, amatsinda ya Methoxy, ntabwo ari hydrophilique nka hydroxypropyl matsinda bityo ntibigire uruhare runini mubushobozi bwo gufata amazi.

ubushyuhe bwibidukikije

Ubushyuhe bwibidukikije ni ikindi kintu kigira ingaruka kumikorere ya HPMC. Mugihe ubushyuhe bwiyongera, ubushobozi bwo gufata amazi ya HPMC buragabanuka. Ibi bibaho kuko kubushyuhe bwo hejuru, iminyururu ya polymer ya HPMC ifite imbaraga za kinetic nyinshi, kandi zigenda vuba. Kubwibyo, molekile zamazi zirekurwa vuba muri materix ya polymer. Nanone, ku bushyuhe bwo hasi, molekile zamazi zirakomera cyane muri matrike ya HPMC, bigatuma amazi agumana cyane.

Niyo mpamvu, ni ngombwa kugenzura ubushyuhe bw’ibidukikije mu gihe cyo gukora kugira ngo amazi agumane kandi yizewe.

Imiterere ya molekulari

Ubushobozi bwo gufata amazi ya HPMC nabwo bugira ingaruka kumiterere ya molekile. Imiterere ya molekuline ya HPMC igenwa nurwego rwo gusimbuza (DS) no gukwirakwiza uburemere bwa molekile.

Urwego rwo gusimbuza bivuga urwego amatsinda ya hydroxyl ya selile asimburwa nitsinda rya hydroxypropyl. HPMC ifite urwego rwo hejuru rwo gusimbuza ifite ubushobozi bwo gufata amazi menshi. Ibinyuranye, HPMC ifite urwego rwo hasi rwo gusimbuza ifite ubushobozi buke bwo gufata amazi.

Ikwirakwizwa ryibiro bya HPMC naryo rigira ingaruka kubushobozi bwo gufata amazi. Iyo uburemere bwa molekile buringaniye, niko ubushobozi bwo gufata amazi, niko molekile nini ikora imiterere ya matrix ikomeye ifata molekile zamazi cyane.

mu gusoza

HPMC ni ibikoresho byingirakamaro cyane kubera uburyo bwiza bwo gufata amazi. Ubushobozi bwo gufata amazi ya HPMC bufitanye isano itaziguye nubwiza bwayo, ibirimo, ubushyuhe bwibidukikije hamwe nimiterere ya molekile. Kubwibyo, guhitamo HPMC iburyo bwa porogaramu isaba gutekereza neza kuri ibi bintu. Muri rusange, HPMC igira ingaruka nziza ku bwiza no gukora neza ku bicuruzwa bitandukanye mu nganda nyinshi, harimo imiti, ibiryo, n’ubwubatsi.