Uburyo bwa Liquid-Icyiciro cyo Kubyaza umusaruro Hydroxypropyl Methyl Cellulose (HPMC)

Hydroxypropyl methyl selulose (HPMC) ni selile ya selile ikoreshwa cyane mubikorwa bitandukanye byinganda na farumasi kubera imiterere myiza yumubiri nubumara. HPMC isanzwe ikorwa muburyo butandukanye, harimo nuburyo bwo gukora ibintu byamazi.

Uburyo bwo gukora ibice byamazi nuburyo bwimiti ikubiyemo reaction ya methyl selulose (MC) hamwe na oxyde ya propylene (PO) hanyuma hamwe na propylene glycol (PG) mubihe bimwe na bimwe. Inzira ikubiyemo intambwe zikurikira:

1. Gutegura Methyl Cellulose (MC)

MC iboneka mukuvura selile hamwe na alkali hanyuma ikayitera methyl chloride. Urwego rwo gusimbuza (DS) rwa MC rugena imiterere yarwo kandi rushobora kugenzurwa no guhindura imiterere yimiterere.

2. Gutegura Oxide ya Propylene (PO)

PO itegurwa na okiside ya propylene ukoresheje umwuka cyangwa ogisijeni imbere ya catalizator. Igisubizo gikorerwa mubushyuhe bwinshi nigitutu kugirango umusaruro mwinshi wa PO.

3. Igisubizo cya MC hamwe na PO

Imyitwarire ya MC hamwe na PO ikorwa imbere ya catalizator hamwe na solve nka toluene cyangwa dichloromethane. Igisubizo ni exothermic kandi gitanga ubushyuhe, bigomba kugenzurwa kugirango wirinde guhunga.

4. Gutegura Propylene Glycol (PG)

PG itegurwa na hydrolysis ya okiside ya propylene ukoresheje amazi cyangwa aside ikwiye cyangwa catalizator. Igisubizo gikozwe mubihe byoroheje kugirango ubone umusaruro mwinshi wa PG.

5. Igisubizo cya MC-PO hamwe na PG

Igicuruzwa cya MC-PO noneho gisubizwa hamwe na PG imbere ya catalizator hamwe nigisubizo nka Ethanol cyangwa methanol. Igisubizo nacyo kidasanzwe kandi gitanga ubushyuhe, bigomba kugenzurwa kugirango wirinde guhunga.

6. Gukaraba no Kuma

Nyuma yo kubyitwaramo, ibicuruzwa byogejwe namazi hanyuma byumishwa kugirango ubone HPMC. Ubusanzwe ibicuruzwa bisukurwa hifashishijwe urukurikirane rwo kuyungurura hamwe na centrifugation intambwe yo gukuraho umwanda uwo ariwo wose.

Uburyo bwo gukora ibice byamazi bifite inyungu nyinshi kurenza ubundi buryo, harimo umusaruro mwinshi, igiciro gito, hamwe nubunini bworoshye. Igisubizo kirashobora gukorerwa mubwato bumwe, bikagabanya ibikenerwa nibikoresho bigoye.

Nyamara, uburyo bwo gukora ibice byamazi nabyo bifite ibibi. Igisubizo kirashobora kubyara ubushyuhe, bugomba kugenzurwa neza kugirango wirinde ibibazo byumutekano. Gukoresha ibishishwa birashobora kandi guteza ingaruka kubidukikije no kubuzima, kandi inzira yo kweza irashobora gutwara igihe kandi igatwara amafaranga menshi.

Mu gusoza, uburyo bwo gukora ibice byamazi nuburyo bukoreshwa cyane mugukora HPMC. Uburyo bukubiyemo reaction ya MC hamwe na PO na PG mubihe bimwe, bikurikirwa no kwezwa no gukama. Mugihe uburyo bufite aho bugarukira, ibyiza byayo bituma uhitamo gukundwa mubikorwa byinganda na farumasi.