Uburyo bwo Kwibiza Imisemburo ya Alkaline Uburyo bwa Hydroxypropyl Methyl Cellulose (HPMC)

Uburyo bwo kwibiza alkaline ni uburyo busanzwe bwo kubyara hydroxypropyl methyl selulose (HPMC). Ubu buryo bukubiyemo reaction ya selile hamwe na hydroxide ya sodium (NaOH) hanyuma hamwe na oxyde ya propylene (PO) na methyl chloride (MC) mubihe bimwe na bimwe.

Uburyo bwo kwibiza alkaline bufite inyungu zo kubyara HPMC hamwe n’urwego rwo hejuru rwo gusimbuza (DS), igena imiterere yarwo nko gukemuka, kwiyegeranya, no kwizana. Uburyo bukubiyemo intambwe zikurikira:

1. Gutegura Cellulose

Cellulose iboneka mumasoko karemano nkibiti, ipamba, cyangwa ibindi bimera. Cellulose yabanje kwezwa hanyuma ikavurwa na NaOH kugirango ikore sodium selulose, ikaba ari intera igaragara hagati yumusaruro wa HPMC.

2. Imyitwarire ya Sodium Cellulose hamwe na Oxide ya Propylene (PO)

Sodium selulose ihita ikorwa na PO imbere ya catalizator nka tetramethylammonium hydroxide (TMAH) cyangwa hydroxide ya sodium (NaOH) mubushyuhe bwinshi hamwe nigitutu. Igisubizo gitera gukora hydroxypropyl selile (HPC).

3. Imyitwarire ya HPC hamwe na Methyl Chloride (MC)

HPC noneho isubizwa hamwe na MC imbere ya catalizator nka sodium hydroxide (NaOH) cyangwa aside hydrochloric (HCl). Ibisubizo bivamo gushiraho hydroxypropyl methyl selulose (HPMC).

4. Gukaraba no Kuma

Nyuma yo kubyitwaramo, ibicuruzwa byogejwe namazi hanyuma byumishwa kugirango ubone HPMC. Ubusanzwe ibicuruzwa bisukurwa hifashishijwe urukurikirane rwo kuyungurura hamwe na centrifugation intambwe yo gukuraho umwanda uwo ariwo wose.

Uburyo bwo kwibiza alkaline bufite inyungu nyinshi kurenza ubundi buryo, harimo DS nini kandi yera, igiciro gito, kandi byoroshye kwipimisha. Uburyo burashobora kandi gukoreshwa mugukora HPMC hamwe nibintu bitandukanye muguhindura imiterere yimiterere nkubushyuhe, umuvuduko, hamwe nibitekerezo.

Nyamara, uburyo nabwo bufite aho bugarukira. Gukoresha NaOH na MC birashobora guteza umutekano muke nibidukikije, kandi inzira yumusaruro irashobora gutwara igihe kandi igasaba ingufu nyinshi.

Mu gusoza, uburyo bwo kwibiza alkaline nuburyo bukoreshwa cyane mugukora HPMC. Uburyo bukubiyemo reaction ya selile hamwe na NaOH, PO, na MC mubihe bimwe, bikurikirwa no kwezwa no gukama. Mugihe uburyo bufite aho bugarukira, ibyiza byayo bituma uhitamo gukundwa mubikorwa byinganda na farumasi.