Hydroxypropyl methyl selulose HPMC ni ubwoko bwa selireose idafite ionic ivanze na ether, itandukanye na ionic methyl carboxymethyl selulose ivanze na ether, kandi ntabwo ikora nibyuma biremereye. Bitewe numubare utandukanye wibintu bya vitamine hamwe nibirimo hydroxypropyl muri hydroxypropyl methylcellulose hamwe na viscosities zitandukanye, byahindutse ubwoko butandukanye bufite imitungo itandukanye, kurugero, vitamine nyinshi hamwe nibirimo hydroxypropyl bike Imikorere yayo iri hafi ya methyl selile, na amoko afite vitamine nkeya hamwe na hydroxypropyl nyinshi, imikorere yayo yegereye hydroxypropyl methylcellulose. Nyamara, muburyo butandukanye, nubwo umubare muto wa hydroxypropyl cyangwa itsinda rito ryitsinda ririmo, gukemura mumashanyarazi cyangwa ubushyuhe bwa flocculation mubisubizo byamazi biratandukanye cyane.
1. Ubushobozi bwa hydroxypropyl methylcellulose
Ububasha bwa hydroxypropyl methyl selulose mumazi Hydroxypropyl methyl selulose mubyukuri ni methyl selulose yahinduwe na okiside ya propylene (methyl oxypropylene), bityo iracyafite imitungo imwe na methyl selile. Cellulose isa no gukonjesha amazi akonje hamwe no kutagira amazi ashyushye. Nyamara, bitewe na hydroxypropyl yahinduwe, ubushyuhe bwayo bwo mumazi ashyushye burenze kure ubwa methyl selile. Kurugero, ubwiza bwumuti wamazi wa hydroxypropyl methylcellulose hamwe na 2% ya metoxyl DS = 0,73 hamwe na hydroxypropyl ibirimo MS = 0.46 ni 500 mpa? S kuri 20 ° C. Ubushyuhe bwa gel burashobora kugera kuri 100 ° C, mugihe methylcellulose mubushuhe bumwe ni 55 ° C. Kubijyanye no gukomera kwayo mumazi, nayo yaratejwe imbere cyane. Kurugero, hydroxypropyl methylcellulose ya pulverized (imiterere ya granular ya 0.2 ~ 0.5mm kuri 20 ° C hamwe nubwiza bwumuti wamazi wa 4% kugeza kuri 2pa? S irashobora gukoreshwa Mubushyuhe bwicyumba, irashobora gushonga byoroshye mumazi idakonje.
SolUbushobozi bwa hydroxypropyl methyl selulose mumashanyarazi ya organic Solubile ya hydroxypropyl methyl selulose mumashanyarazi ya organic nayo iruta iya methyl selulose, kandi methyl selulose igomba kuba ifite urwego rwo gusimbuza metoxyl kubicuruzwa biri hejuru ya 2.1, hamwe na hydroxypropyl methylcellulose. hydroxypropyl MS = 1.5 ~ 1.8 na mikorobe DS = 0.2 ~ 1.0, hamwe nimpamyabumenyi yose yo gusimbuza hejuru ya 1.8 irashonga muri anhydrous methanol na Ethanol ibisubizo biciriritse, thermoplastique hamwe n-amazi. Irashobora kandi gushonga muri hydrocarbone ya chlorine nka dichloromethane na chloroform, no mumashanyarazi kama nka acetone, isopropanol na alcool ya diacetone. Gukemura kwayo mumashanyarazi kama nibyiza kuruta gushonga amazi.
2. Ibintu bigira ingaruka ku bwiza bwa hydroxypropyl methylcellulose
Ingaruka ziterwa na hydroxypropyl methyl selulose viscosity Igenamigambi risanzwe rya hydroxypropyl methyl selulose, kimwe nizindi selile ya selile, ishingiye kumuti wa 2% wamazi kuri 20 ° C. Ubukonje bwibicuruzwa bimwe byiyongera hamwe no kwiyongera kwibitekerezo. Kubicuruzwa bifite uburemere butandukanye bwa molekuline kumurongo umwe, ibicuruzwa bifite uburemere bunini bwa molekile bifite ubwiza bwinshi. Isano yayo nubushyuhe isa nubwa methyl selulose. Iyo ubushyuhe bwiyongereye, ibishishwa bitangira kugabanuka, ariko iyo bigeze ku bushyuhe runaka, ubwiza bwiyongera butunguranye kandi gelation iba. Ubushyuhe bwa gel bwibicuruzwa biri hasi cyane. ni hejuru. Ingingo ya gel yayo ntabwo ifitanye isano gusa nubwiza bwa ether gusa, ahubwo ifitanye isano nikigereranyo cyimikorere ya mitoxy na hydroxypropyl muri ether hamwe nurwego rwose rwo gusimburwa. Twabibutsa ko hydroxypropyl methylcellulose nayo ari pseudoplastique kandi igisubizo cyacyo gihamye mubushyuhe bwicyumba nta kwangirika kwijimye keretse hashobora kubaho kwangirika kwimisemburo.
3. Hydroxypropyl methylcellulose aside hamwe na alkali irwanya
Hydroxypropyl methylcellulose aside hamwe na alkali irwanya Hydroxypropyl methylcellulose muri rusange ihagaze neza kuri aside na alkali, kandi ntabwo igira ingaruka mubipimo bya pH 2 ~ 12. Irashobora kwihanganira urugero runaka rwa acide. Nka acide formique, acide acike, acide citric, acide succinic, acide fosifori, aside boric, nibindi, ariko, aside yibanze ifite ingaruka zo kugabanya ububobere. Alkali nka soda ya caustic, potas ya caustic n'amazi ya lime ntacyo bigira kuri yo, ariko irashobora kongera gato ubwiza bwumuti, hanyuma hazabaho ikibazo cyo kugabanuka gahoro mugihe kizaza.
4. Kuvanga hydroxypropyl methylcellulose
Miscibility ya Hydroxypropyl Methyl Cellulose Hydroxypropyl methyl selulose yumuti irashobora kuvangwa nuruvange rwamazi ya polymer kugirango ibe igisubizo kimwe kandi kiboneye hamwe nubwiza bwinshi. Ibi bikoresho bya polymer birimo polyethylene glycol, acetate ya polyvinyl, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl selulose na methyl selulose. Ibikoresho bisanzwe bya polymer nka gum arabic, inzige ibishyimbo, karaya gum, nibindi nabyo bivanga neza nigisubizo cyacyo. Hydroxypropyl methylcellulose irashobora kandi kuvangwa na mannitol cyangwa sorbitol ester ya acide stearic cyangwa aside palmitike, kandi ishobora no kuvangwa na glycerine, sorbitol na mannitol. Izi mvange zirashobora gukoreshwa nka hydroxypropyl methylcellulose. Amashanyarazi ashingiye kuri selile.
5. Kudashobora gukomera no gukama amazi ya hydroxypropyl methylcellulose
Amazi adashobora gushonga ya selile yamashanyarazi ya hydroxypropyl methylcellulose irashobora guhuzwa hejuru na aldehydes, kandi izo ether zishonga mumazi ziragwa mumuti hanyuma zigahinduka amazi. Aldehydes ituma hydroxypropyl methylcellulose idashobora gushonga harimo fordehide, glyoxal, succinaldehyde, adipaldehyde, nibindi. Iyo ukoresheje formaldehyde, hagomba kwitabwaho byumwihariko agaciro ka pH kumuti, muribwo glyoxal ikora vuba. Kubwibyo, glyoxal isanzwe ikoreshwa nkibintu byuzuzanya mubikorwa byinganda. Ingano yubu bwoko bwa agent ihuza mugisubizo ni 0.2% ~ 10% ya misa ya ether, nibyiza 7% ~ 10%, na 3.3% ~ 6% nibyo bibereye glyoxal. Ubushyuhe rusange bwo kuvura ni 0 ~ 30 ℃, kandi igihe ni 1 ~ 120min. Igikorwa cyo guhuza ibikorwa kigomba gukorwa mugihe cya acide. Mubisanzwe, acide organic organique cyangwa acide karubasi ya acide yongewe kumuti kugirango uhindure pH yumuti kuri 2 ~ 6, byaba byiza hagati ya 4 ~ 6, hanyuma aldehydes yongeweho kugirango ikore reaction ihuza. . Acide yakoreshejwe irimo aside hydrochloric, aside sulfurike, aside fosifori, aside aside, aside acike, aside hydroxyacetic aside, acide succinic cyangwa aside citricike, muribwo aside irike cyangwa aside irike ikwiye, kandi aside irike niyo nziza cyane. Acide na aldehyde birashobora kandi kongerwamo icyarimwe kugirango byemere igisubizo guhuza murwego rwa pH wifuza. Iyi reaction ikoreshwa kenshi muburyo bwa nyuma bwo kuvura mugutegura selile ya selile. Ether ya selulose imaze gushiramo, biroroshye koza no kweza n'amazi kuri 20 ~ 25 ° C. Iyo ibicuruzwa biri gukoreshwa, ibintu bya alkaline birashobora kongerwaho igisubizo cyibicuruzwa kugirango uhindure pH yumuti kugirango ube alkaline, kandi ibicuruzwa bizashonga mubisubizo byihuse. Ubu buryo burakoreshwa no mubisubizo bya selile ya ether yakozwe muri firime hanyuma firime iratunganywa kugirango ibe firime idashonga.
6. Hydroxypropyl methylcellulose irwanya imisemburo
Hydroxypropyl methylcellulose irwanya imisemburo. Mubyigisho, ibikomoka kuri selile, nka buri tsinda rya anhydroglucose, bifite itsinda risimburana rifatanije, ritoroshye kwanduzwa na mikorobe, ariko mubyukuri ibicuruzwa byarangiye Iyo agaciro gasimbuye karenze 1, bizanatesha agaciro imisemburo, bivuze ko urwego rwo gusimbuza buri tsinda kumurongo wa selile ridahuje bihagije, kandi mikorobe irashobora kwangirika hafi yitsinda rya anhydroglucose ridafite ishingiro kugirango ribe isukari. , zinjizwa nkintungamubiri za mikorobe. Kubwibyo, niba urwego rwo gusimbuza etherification ya selile yiyongereye, kurwanya isuri yimisemburo ya selile ya ether nayo irongerwa. Biravugwa ko ubukonje busigaye bwa hydroxypropyl methylcellulose (DS = 1.9) ari 13.2%, methylcellulose (DS = 1.83) ni 7.3%, na methylcellulose (DS = 1.66) ni 3,8%, na hydroxyethyl selile ni 1,7%. Birashobora kugaragara ko ubushobozi bwo kurwanya enzyme ya hydroxypropyl methylcellulose ikomeye. Kubwibyo, enzyme nziza cyane irwanya hydroxypropyl methylcellulose, ifatanije nogukwirakwiza kwayo neza, kubyimba no gukora firime, mubisanzwe bikoreshwa mumazi-emulsiya yamazi, nibindi, kandi mubisanzwe ntibisaba kongeramo imiti igabanya ubukana. Nyamara, kububiko bwigihe kirekire bwibisubizo cyangwa ibishoboka byose kwanduza isi, kubungabunga ibidukikije birashobora kongerwaho muburyo bwo kwirinda, kandi guhitamo birashobora kugenwa ukurikije ibisabwa byanyuma byigisubizo. Fenilmercuric acetate na fluorosilicate ya manganese ni ibintu birinda ibintu neza, ariko bifite Uburozi bwombi, hagomba kwitabwaho kubaga, kandi muri rusange dosiye ni 1 ~ 5mg ya acetate ya fenylmercuric kuri litiro yumuti.
7. Ibyiza bya hydroxypropyl methylcellulose
Imikorere ya hydroxypropyl methylcellulose ya firime Hydroxypropyl methylcellulose ifite imiterere myiza yo gukora firime, kandi igisubizo cyamazi cyayo cyangwa igisubizo cyumuti kama cyashizwe kumasahani yikirahure, kandi kiba ibara kandi kibonerana nyuma yo gukama. Kandi firime ikomeye. Ifite ubushyuhe bwiza kandi ikomeza gukomera ku bushyuhe bwinshi. Kurugero, kongeramo plasitike ya hygroscopique birashobora kongera uburebure no guhinduka. Kugirango uhindure ibintu byoroshye, plasitike nka glycerine na sorbitol nibyo byiza cyane. Igisubizo rusange cyibisubizo ni 2% ~ 3%, naho plastiseri ni 10% ~ 20% ya selile ya ether. Niba ibirimo plasitike ari byinshi cyane, kugabanuka kwamazi ya colloid dehydrasiyo bizaba munsi yubushyuhe bwinshi. Imbaraga zingana za firime hamwe na plasitike yongeweho nini cyane kuruta iyo idafite plastike, kandi iriyongera hamwe no kwiyongera kwamafaranga yiyongereye. Kubijyanye na hygroscopicity ya firime, nayo iriyongera hamwe no kwiyongera kwa plastike.
Igihe cyo kohereza: Ukwakira-13-2022