Kwiga ku myitwarire ya rheologiya ya konjac glucomannan na hydroxypropyl methylcellulose sisitemu

Sisitemu ikomatanya ya konjac glucomannan (KGM) na hydroxypropyl methylcellulose (HPMC) yafashwe nkikintu cyubushakashatsi, kandi ibizamini byo guhindagura leta, inshuro nyinshi hamwe nubushyuhe bwo gukorerwa ubushyuhe byakorewe kuri sisitemu yikomatanya na rheometero. Hasesenguwe ingaruka z'igice kinini cy'igisubizo hamwe n'ikigereranyo cyo kugereranya ku miterere n'imiterere ya sisitemu ya KGM / HPMC. Ibisubizo byerekana ko sisitemu ya KGM / HPMC ari amazi atari Newtonian, kandi kwiyongera mubice byinshi hamwe na KGM biri muri sisitemu bigabanya umuvuduko wibisubizo byimbaraga kandi byongera ubwiza. Muri leta ya sol, KGM na HPMC iminyururu ya molekile ikora imiterere yoroheje binyuze mumikoranire ya hydrophobique. Kongera sisitemu ibice byinshi hamwe nibirimo bya KGM bifasha mukubungabunga ituze ryimiterere. Muri sisitemu yo kugabanya ibice bike, kongera ibikubiye muri KGM ni ingirakamaro mugukora geles ya termotropique; mugihe muri sisitemu nini yo kugabanya ibice, kongera ibiri muri HPMC bifasha muburyo bwo gukora gelesotropique.

Amagambo y'ingenzi:konjac glucomannan; hydroxypropyl methylcellulose; urugimbu; imyitwarire ya rheologiya

Polysaccharide isanzwe ikoreshwa cyane munganda zibiribwa bitewe nubunini bwazo, emulisitiya na gell. Konjac glucomannan (KGM) ni igihingwa gisanzwe polysaccharide, kigizweβ-D-glucose naβ-D-mannose mu kigereranyo cya 1.6: 1, byombi bihujwe naβ-1,4 glycosidic bonds, muri C- Hano hari acetyl nkeya kumwanya wa 6 (hafi acetyl 1 kuri buri bisigara 17). Nyamara, ubwinshi bwubwinshi nubwinshi bwamazi ya KGM yumuti wamazi bigabanya gukoreshwa mubikorwa. Hydroxypropyl methylcellulose (HPMC) ni propylene glycol ether ya methylcellulose, ikaba ari iy'uturemangingo tutari ionic selile. HPMC ikora firime, ikabura amazi, kandi ishobora kuvugururwa. HPMC ifite ubukonje buke n'imbaraga za gel ku bushyuhe buke, kandi imikorere idahwitse yo gutunganya, ariko irashobora gukora geli isa nini cyane isa na gel mu bushyuhe bwinshi, bityo rero inzira nyinshi zo kubyaza umusaruro zigomba gukorwa mubushyuhe bwinshi, bigatuma ingufu zikoreshwa cyane. Ibiciro byumusaruro ni byinshi. Ubuvanganzo bwerekana ko igice cya mannose kidashidikanywaho kumurongo wa molekuline ya KGM gishobora gukora akarere gahuza hydrophobi gahuza gahoro gahoro hamwe nitsinda rya hydrophobique kumurongo wa HPMC binyuze mumikoranire ya hydrophobique. Iyi miterere irashobora gutinza no gukumira igice cyumuriro wa HPMC no kugabanya ubushyuhe bwa gel ya HPMC. Byongeye kandi, urebye imiterere-ya-viscosity ya HPMC ku bushyuhe buke ugereranyije, hateganijwe ko guhuza kwayo na KGM bishobora guteza imbere imiterere-yuzuye ya KGM no kunoza imikorere yayo. Kubwibyo, iyi mpapuro izubaka sisitemu yo guhuza KGM / HPMC kugirango ishakishe ingaruka ziterwa nigice kinini cyibisubizo hamwe nigereranya ryimiterere kumiterere ya rheologiya ya sisitemu ya KGM / HPMC, kandi itange ibitekerezo byerekana ikoreshwa rya sisitemu ya KGM / HPMC muri inganda z'ibiribwa.

1. Ibikoresho nuburyo

1.1 Ibikoresho na reagent

Hydroxypropyl methylcellulose, KIMA CHIMICAL CO., LTD, igice kinini cya 2%, viscosity 6 mPa·s; igice kinini cya metxyxy 28% ~ 30%; hydroxypropyl igice kinini 7.0% ~ 12%.

Konjac glucomannan, Wuhan Johnson Konjac Food Co., Ltd., 1 wt% yumuti wamazi≥28 000 mPa·s.

1.2 Ibikoresho n'ibikoresho

MCR92 izenguruka rheometero, Anton Paar Co, Ltd., Otirishiya; Imashini y'amazi ya UPT-II-10T, Sichuan Youpu Ultrapure Technology Co., Ltd.; AB-50 isesengura rya elegitoroniki, isosiyete yo mu Busuwisi Mette; LHS-150HC ihora yubushyuhe bwamazi, Wuxi Huaze Technology Co., Ltd.; JJ-1 Amashanyarazi, Uruganda rwibikoresho byubuvuzi bya Jintan, Intara ya Jiangsu.

1.3 Gutegura igisubizo kivanze

Gupima ifu ya HPMC na KGM ifite igipimo runaka cyo guhuza (igipimo rusange: 0:10, 3: 7, 5: 5, 7: 3, 10: 0), ubyongere buhoro buhoro mumazi ya deioni muri 60°C kwiyuhagira amazi, hanyuma ukangure kuri 1.5 ~ 2 h kugirango itatanye neza, hanyuma utegure ubwoko 5 bwibisubizo bya gradient hamwe nuduce twinshi twa 0,50%, 0,75%, 1.00%, 1.25%, na 1.50%.

1.4 Kugerageza imiterere ya rheologiya yumuti ukomatanya

Ikigeragezo gihamye cya leta: Umurongo wa rheologiya wumuti wa KGM / HPMC wapimwe hifashishijwe cone na plaque ya CP50, ikinyuranyo hagati yamasahani yo hejuru no hepfo cyashyizwe kuri 0.1 mm, ubushyuhe bwo gupima bwari 25°C, kandi igipimo cyogosha cyari 0.1 kugeza 100 s-1.

Gusikana kumurongo (kugena akarere ka viscoelastique)°C. Urwego rutoroshye ni 0.1% ~ 100%.

Gukuraho inshuro nyinshi: Koresha isahani ya PP50 kugirango upime impinduka ya modulus hamwe ninshuro zishingiye kubisubizo bya KGM / HPMC. Umwanya washyizwe kuri mm 1.000, umutwaro ni 1%, ubushyuhe bwo gupima ni 25°C, kandi intera yumurongo ni 0.1-100 Hz.

Gusikana ubushyuhe: Modulus hamwe nubushyuhe bwayo biterwa nigisubizo cya KGM / HPMC cyapimwe hifashishijwe isahani ya PP50, intera yashyizwe kuri mm 1.000, inshuro yagenwe yari 1 Hz, deformasiyo yari 1%, kandi ubushyuhe bwari kuva kuri 25 kugeza 90°C.

2. Ibisubizo nisesengura

2.1 Isesengura ryumurongo wa sisitemu ya KGM / HPMC

Viscosity na shear igipimo cyimirongo ya KGM / HPMC ibisubizo hamwe nibipimo bitandukanye byo guhuza ibice bitandukanye. Amazi afite ubwiza bwumurongo wumurongo wikigereranyo cyitwa Newtonian fluids, naho ubundi bita non-Newtonian fluid. Birashobora kugaragara uhereye kumurongo ko viscosity yumuti wa KGM hamwe na KGM / HPMC ikomatanya igabanuka hamwe no kwiyongera kwikigereranyo; murwego rwohejuru rwa KGM, niko sisitemu ya misa igabanijwe, kandi biragaragara ko icyogosha cyoroshye cyo gukemura. Ibi birerekana ko sisitemu ya KGM na KGM / HPMC ari ibintu bitari Newtonian, kandi ubwoko bwamazi ya sisitemu ya KGM / HPMC bugenwa cyane na KGM.

Uhereye ku bipimo ngenderwaho hamwe na coefficient ya viscosity ya KGM / HPMC ibisubizo hamwe nibice bitandukanye hamwe nibice bitandukanye, urashobora kubona ko n indangagaciro za sisitemu ya KGM, HPMC na KGM / HPMC zose ziri munsi ya 1, byerekana ko ibisubizo ari ibintu byose bya pseudoplastique. Kuri sisitemu ya KGM / HPMC, kwiyongera kwagace kinshi ka sisitemu bizatera kwizirika hamwe nubundi bufatanye hagati yiminyururu ya HPMC na KGM mubisubizo, bizagabanya umuvuduko wiminyururu ya molekile, bityo bigabanye n agaciro ka Sisitemu. Muri icyo gihe, hamwe no kwiyongera kwa KGM, imikoranire hagati yiminyururu ya KGM muri sisitemu ya KGM / HPMC iratera imbere, bityo bikagabanya umuvuduko wacyo bigatuma igabanuka ryagaciro. Ibinyuranye, K agaciro k'ibisubizo bya KGM / HPMC byiyongera ubudahwema hamwe no kwiyongera k'igice kinini cy'ibisubizo hamwe n'ibirimo bya KGM, ibyo bikaba ahanini biterwa no kwiyongera kw'igice cya sisitemu hamwe n'ibirimo KGM, byombi byongera ibiri muri amatsinda ya hydrophilique muri sisitemu. , kongera imikoranire ya molekuline mumurongo wa molekile no hagati yumunyururu, bityo ukongera radiyo hydrodynamic radiyo ya molekile, bigatuma bidashoboka ko yerekezwa kubikorwa byimbaraga zogosha no kongera ubwiza.

Agaciro ka theoretical ya zero-shear viscosity ya sisitemu ya KGM / HPMC irashobora kubarwa ukurikije ihame rya logarithmic yavuzwe haruguru, kandi agaciro kayo k'igeragezwa gashobora kuboneka na Carren ikwiranye na extrapolation ya viscosity-shear rate curve. Ugereranije agaciro kateganijwe kuri zeru-shear viscosity ya sisitemu ya KGM / HPMC hamwe nuduce duto twinshi hamwe nu mibare itandukanye yo guhuza hamwe nagaciro kageragejwe, urashobora kubona ko agaciro nyako ka zeru-shear viscosity ya KGM / HPMC igisubizo ni gito kuruta agaciro ka theoretical. Ibi byerekanaga ko inteko nshya ifite imiterere yuzuye yashizweho muri sisitemu igoye ya KGM na HPMC. Ubushakashatsi buriho bwerekanye ko ibice bya mannose bidasubirwaho kumurongo wa molekuline ya KGM bishobora gukorana nitsinda rya hydrophobique kumurongo wa molekile ya HPMC kugirango bibe akarere gahuza hydrophobique ihuza akarere. Biravugwa ko imiterere yinteko nshya ifite imiterere igereranije ikorwa ahanini binyuze mumikoranire ya hydrophobique. Iyo igipimo cya KGM kiri hasi (HPMC> 50%), agaciro nyako ka zeru-shear viscosity ya sisitemu ya KGM / HPMC iri munsi ugereranije nagaciro kerekana, ibyo bikaba byerekana ko kubintu bike bya KGM, molekile nyinshi zitabira denser nshya imiterere. Mugushiraho kwa, zeru-shear viscosity ya sisitemu iragabanuka.

2.2 Isesengura ryimyitozo ngororamubiri ya sisitemu ya KGM / HPMC

Uhereye ku murongo ufitanye isano na modulus hamwe nogukemura ibibazo bya KGM / HPMC hamwe nibice bitandukanye hamwe nibice bitandukanye byuzuzanya, birashobora kugaragara ko mugihe umutwaro wogosha uri munsi ya 10%, G′na G.″ya sisitemu yo guhuza mubyukuri ntabwo yiyongera hamwe nogosha. Ariko, irerekana ko muriki gice cyogosha cyogosha, sisitemu yimvange irashobora gusubiza ibintu bitera imbaraga binyuze mumihindagurikire yimikorere ya molekile, kandi imiterere ya sisitemu yangiritse ntabwo yangiritse. Iyo umutemeri wogosha ari> 10%, hanze Hifashishijwe ibikorwa byimbaraga zogosha, umuvuduko wo gutandukanya iminyururu ya molekile muri sisitemu igoye iruta umuvuduko wo gufunga, G′na G.″tangira kugabanuka, kandi sisitemu yinjira mukarere ka viscoelastic. Kubwibyo, mugihe cyakurikiyeho dinamike yikizamini, ibipimo bya shear strain byatoranijwe nka 1% yo kwipimisha.

2.3 Isesengura ryibihe byinshi byo gusesengura sisitemu ya KGM / HPMC

Guhinduranya gutandukanya ububiko bwububiko hamwe nigihombo modulus hamwe numurongo wa KGM / HPMC ibisubizo hamwe nibipimo bitandukanye byo guhuza munsi yibice bitandukanye. Ububiko bwa modulus G 'bugereranya ingufu zishobora kugarurwa nyuma yo kubikwa by'agateganyo mu kizamini, kandi igihombo modulus G ”bisobanura imbaraga zisabwa mu gutembera kwambere, bikaba igihombo kidasubirwaho kandi amaherezo gihinduka ubushyuhe bukabije. Birashobora kugaragara ko, hamwe Nkuko inshuro zinyeganyega ziyongera, igihombo modulus G.″ni burigihe kuruta ububiko modulus G.′, kwerekana imyitwarire y'amazi. Mubipimo byikigereranyo, ububiko bwa G 'hamwe nigihombo modulus G ”byiyongera hamwe no kwiyongera kwinshyi. Ibi biterwa cyane cyane nuko hamwe no kwiyongera kwinshyi zinyeganyega, ibice byurunigi rwa molekuline muri sisitemu nta mwanya wo gukira byahinduwe mugihe gito leta yabanjirije iyi, bityo bikerekana ibintu byerekana ko ingufu nyinshi zishobora kubikwa ( binini G.′) cyangwa bigomba gutakara (G.″).

Hamwe no kwiyongera kwinyeganyeza, modulus yo kubika sisitemu igabanuka gitunguranye, kandi hamwe no kwiyongera kwagace kinshi hamwe na KGM yibiri muri sisitemu, aho inshuro zigabanuka gitunguranye ziyongera buhoro buhoro. Igabanuka ritunguranye rishobora guterwa no gusenya imiterere yimikorere yashizweho nishyirahamwe rya hydrophobique hagati ya KGM na HPMC muri sisitemu mukwogosha hanze. Byongeye kandi, kwiyongera kwa sisitemu yibice byinshi hamwe nibirimo bya KGM ni ingirakamaro kugirango ugumane ituze ryimiterere yubucucike, kandi byongerera agaciro inshuro zo hanze zangiza imiterere.

2.4 Isesengura ry'ubushyuhe bwo gusesengura isesengura rya sisitemu ya KGM / HPMC

Uhereye kumurongo wo kubika modulus no gutakaza modulus ya KGM / HPMC ibisubizo hamwe nibice bitandukanye hamwe nibice bitandukanye byo guhuza, birashobora kugaragara ko mugihe igice kinini cya sisitemu ari 0,50%, G′na G.″ya HPMC igisubizo ntigishobora guhinduka hamwe nubushyuhe. , na G.″> G.′, ubwiza bwa sisitemu yiganje; iyo igice kinini cyiyongereye, G.′cya HPMC igisubizo kibanza kidahinduka hanyuma kikiyongera cyane, na G.′na G.″guhuza hafi 70°C. Kubisubizo bya KGM, mugihe igice kinini cya sisitemu ari 0,50% na 0,75%, G.′na G ya sisitemu “yerekana inzira igabanuka; iyo igice kinini cyiyongereye, G 'na G ”yumuti wa KGM ubanza kugabanuka hanyuma ukiyongera cyane, ibyo bikaba byerekana ko igisubizo cya KGM kigaragaza imitungo isa na gel mubice byinshi hamwe nubushyuhe bwinshi.

Hamwe n'ubwiyongere bw'ubushyuhe, G.′na G.″ya sisitemu ya KGM / HPMC yabanje kugabanuka hanyuma yiyongera cyane, na G.′na G.″byagaragaye aho bihurira, kandi sisitemu yakoze gel. Iyo molekile ya HPMC iri ku bushyuhe buke, guhuza hydrogène bibaho hagati yitsinda rya hydrophilique kumurongo wa molekile na molekile zamazi, kandi iyo ubushyuhe buzamutse, ubushyuhe bwakoreshejwe busenya imigozi ya hydrogène iba hagati ya HPMC na molekile zamazi, bigatuma habaho macromolecular ya HPMC. iminyururu. Amatsinda ya hydrophobi hejuru aragaragara, ishyirahamwe rya hydrophobique rirabaho, hamwe na gel ya termotropique. Kuri sisitemu yo kugabanya ibice bike, ibintu byinshi bya KGM birashobora gukora gel; kuri sisitemu yo kugabanya ibice byinshi, ibintu byinshi bya HPMC birashobora gukora gel. Muri sisitemu yo kugabanya uduce duto (0,50%), kuba molekile ya KGM igabanya amahirwe yo gukora hydrogène ihuza molekile ya HPMC, bityo bikongerera amahirwe yo guhura nitsinda rya hydrophobique muri molekile ya HPMC, bifasha gukora geles ya termotropique. Muri sisitemu yo kugabanya ibice byinshi, niba ibikubiye muri KGM ari byinshi cyane, ubwiza bwa sisitemu ni bwinshi, ibyo bikaba bidahuye n’ishyirahamwe rya hydrophobique riri hagati ya molekile ya HPMC na KGM, ridafasha gukora geli ya termogene.

3. Umwanzuro

Muri iyi nyandiko, imyitwarire ya rheologiya ya sisitemu yo guhuza KGM na HPMC irigwa. Ibisubizo byerekana ko sisitemu yo guhuza KGM / HPMC ari amazi atari Newtonian, kandi ubwoko bwamazi ya sisitemu yo guhuza KGM / HPMC bugenwa cyane na KGM. Kongera sisitemu ibice byinshi hamwe nibirimo bya KGM byombi byagabanije gutembera kwumuti wibisubizo kandi byongera ubwiza bwabyo. Muri leta ya sol, iminyururu ya molekuline ya KGM na HPMC ikora imiterere yuzuye binyuze mumikoranire ya hydrophobique. Imiterere muri sisitemu isenywa no kogosha hanze, bikavamo kugabanuka gutunguranye mububiko bwa sisitemu. Ubwiyongere bwa sisitemu yibice byinshi hamwe nibirimo bya KGM ningirakamaro kugirango ugumane ituze ryimiterere yubucucike no kongera agaciro ka frequency yo hanze yangiza imiterere. Kuri sisitemu yo kugabanya ibice bike, ibintu byinshi bya KGM bifasha gukora gel; kuri sisitemu nini yo kugabanya ibice byinshi, ibintu byinshi bya HPMC bifasha gukora gel.