Kwiga kugenzura ubuziranenge bwa Hydroxypropyl Methyl Cellulose

Ukurikije uko umusaruro wa HPMC uriho ubu mu gihugu cyanjye, hasesenguwe ibintu bigira ingaruka ku bwiza bwa hydroxypropyl methylcellulose, kandi hashingiwe ku buryo bwo kuzamura urwego rwiza rwa hydroxypropyl methylcellulose biganirwaho kandi biga, kugira ngo bibyare umusaruro.

Amagambo y'ingenzi:hydroxypropyl methylcellulose; ubuziranenge; kugenzura; ubushakashatsi

Hydroxypropyl methylcellulose (HPMC) ni selile idafite amazi ya elegitoronike ivanze na eferi ikozwe mu ipamba, ibiti, kandi igashyirwa hamwe na oxyde ya propylene na methyl chloride nyuma yo kubyimba alkali. Cellulose ivanze na ether ni ihindurwa ryibikomoka kuri ether imwe isimbuza ether ifite imiterere yihariye kuruta iyambere yambere, kandi irashobora gukina imikorere ya selile ether muburyo bwuzuye kandi neza. Muri ethers nyinshi zivanze, hydroxypropyl methylcellulose ningirakamaro cyane. Uburyo bwo gutegura ni ukongeramo okiside ya propylene kuri selile ya alkaline. Inganda HPMC zishobora gusobanurwa nkibicuruzwa rusange. Urwego rwo gusimbuza itsinda rya methyl (agaciro ka DS) ni 1,3 kugeza kuri 2.2, naho urwego rwo gusimbuza amara ya hydroxypropyl ni 0.1 kugeza 0.8. Birashobora kugaragara uhereye kumibare yavuzwe haruguru ko ibirimo numutungo wa methyl na hydroxypropyl muri HPMC bitandukanye, bikavamo ubwiza bwibicuruzwa byanyuma kandi Itandukaniro ryuburinganire biganisha ku ihindagurika ryubwiza bwibicuruzwa byarangiye byinganda zitandukanye.

Hydroxypropyl methylcellulose itanga ibikomoka kuri ether binyuze mumiti ya chimique, bigira impinduka zikomeye mubigize, imiterere n'imiterere, cyane cyane solubile ya selile, ishobora gutandukana ukurikije ubwoko nubunini bwamatsinda ya alkyl yatangijwe. Kubona ibikomoka kuri ether bishonga mumazi, kuvanga alkali yumuti, kumashanyarazi ya polar (nka Ethanol, propanol) hamwe nudukoko twinshi twa polarike (nka benzene, ether), byagura cyane ubwoko hamwe nimirima ikoreshwa mubikomoka kuri selile.

1. Ingaruka za hydroxypropyl methylcellulose alkalisation yuburyo bwiza

Igikorwa cya alkalisation nintambwe yambere murwego rwo kubyitwaramo HPMC, kandi nayo ni imwe muntambwe zikomeye. Ubwiza bwihariye bwibicuruzwa bya HPMC bugenwa ahanini nuburyo bwa alkalisation, ntabwo ari inzira ya etherification, kuko ingaruka ya alkalisation igira ingaruka itaziguye ingaruka za etherification.

Hydroxypropyl methylcellulose ikorana nigisubizo cya alkaline kugirango ikore selile alkali selile, ikora cyane. Muri reaction ya etherification, reaction nyamukuru yumukozi wa etherification kubyimba, kwinjira, na etherifike ya selile na Igipimo cyibisubizo byuruhande, uburinganire bwibisubizo hamwe nibicuruzwa byanyuma byose bifitanye isano no gushiraho no guhimba alkali selulose, imiterere rero nimiterere yimiti ya alkali selulose nibintu byingenzi byubushakashatsi mubikorwa bya selile ya ether.

2. Ingaruka yubushyuhe kumiterere ya hydroxypropyl methylcellulose

Muburyo bumwe bwibisubizo byamazi ya KOH, ingano ya adsorption hamwe nu mubyimba wa hydroxypropyl methylcellulose kuri alkali yiyongera hamwe nubushyuhe bwubushyuhe. Kurugero, ibisohoka bya alkali selulose biratandukana hamwe na KOH: 15%, 8% kuri 10°C, na 4.2% kuri 5°C. Uburyo bwiyi nzira ni uko kwibumbira muri alkali selulose ari inzira idasanzwe. Mugihe ubushyuhe buzamutse, adsorption ya hydroxypropyl methylcellulose kuri alkali Umubare uragabanuka, ariko hydrolysis reaction ya alkali selulose yiyongera cyane, ntabwo ifasha gukora selile ya alkali. Birashobora kugaragara uhereye hejuru ko kugabanya ubushyuhe bwa alkalisation bifasha kubyara alkali selile kandi bikabuza hydrolysis reaction.

3. Ingaruka yinyongera kumiterere ya hydroxypropyl methylcellulose

Muri selile-KOH-sisitemu y'amazi, inyongera-umunyu ufite uruhare runini mu mikorere ya alkali selile. Iyo kwibumbira hamwe kwa KOH biri munsi ya 13%, adsorption ya selile kuri alkali ntabwo ihindurwa no kongeramo umunyu wa potasiyumu chloride. Iyo kwibumbira hamwe byumuti wa lye urenze 13%, nyuma yo kongeramo potasiyumu chloride, bigaragara ko adsorption ya selulose kuri alkali Adorption yiyongera hamwe na chloride ya potasiyumu, ariko ubushobozi bwa adsorption buragabanuka, kandi amazi yiyongera cyane, bityo rero kongeramo umunyu mubisanzwe ntabwo ari bibi kuri alkalisation no kubyimba kwa selile, ariko umunyu urashobora kubuza hydrolysis no kugenga sisitemu Ibiri mumazi yubusa bityo bitezimbere ingaruka za alkalisation na etherification.

4. Ingaruka yumusaruro ku bwiza bwa hydroxypropyl methylcellulose

Kugeza ubu, hydroxypropyl methylcellulose inganda zitanga umusaruro mugihugu cyanjye ahanini zikoresha uburyo bwo kubyaza umusaruro uburyo bwo kwishyura. Gutegura na etherifike ya alkali selulose byose bikorerwa mumashanyarazi ya inert, bityo rero ibikoresho fatizo bitunganijwe neza bigomba guhindurwa kugirango ubone ubuso bunini bwa Surface hamwe nubushake kugirango harebwe ubuziranenge bwibicuruzwa byarangiye.

Ongeramo selile ya pululize, solge organique hamwe nigisubizo cya alkali mumashanyarazi, hanyuma ukoreshe imashini ikomeye ikurura ubushyuhe nigihe runaka kugirango ubone selile ya alkali hamwe na alkalisation imwe kandi itangirika cyane. Umuyoboro wa dilution (isopropanol, toluene, nibindi) ufite ubudahangarwa runaka, butuma hydroxypropyl methylcellulose isohora ubushyuhe bumwe mugihe cyibikorwa, ikerekana intambwe yo kurekura intambwe, mugihe ugabanya hydrolysis reaction ya alkali selulose muburyo bunyuranye Kugirango ubone byinshi- ubuziranenge bwa alkali selile, mubisanzwe kwibumbira hamwe kwa lye ikoreshwa muriyi link ni hejuru ya 50%.

Iyo selile imaze gushiramo lye, yabyimbye rwose kandi iringaniye alkali selile. Lye osmotically kubyimba selile neza, igashyiraho urufatiro rwiza rwibisubizo bya etherification. Amazi asanzwe arimo cyane cyane isopropanol, acetone, toluene, nibindi. Gukomera kwa lye, ubwoko bwimiterere no gukurura ibintu nibintu nyamukuru bigira ingaruka kumiterere ya selile ya alkali. Hejuru no hepfo ibice byakozwe iyo bivanze. Igice cyo hejuru kigizwe na isopropanol n'amazi, naho igice cyo hepfo kigizwe na alkali hamwe na isopropanol nkeya. Cellulose ikwirakwijwe muri sisitemu irahuza rwose nu gice cyo hejuru no hepfo y'amazi munsi yo gukanika imashini. Alkali muri sisitemu Uburinganire bwamazi burahinduka kugeza selile.

Nka selile isanzwe idafite ionic ivanze ether, ibiri mumatsinda ya hydroxypropyl methylcellulose iri kumurongo wa macromolecular itandukanye, ni ukuvuga ko ikwirakwizwa ryamatsinda ya methyl na hydroxypropyl ritandukanye kuri C ya buri mwanya wa glucose. Ifite itandukaniro ryinshi kandi ridahwitse, bigatuma bigora kwemeza ubwiza bwibicuruzwa.