Ibikoresho bya farumasi Cellulose Ether

Kamere ya selile isanzwe ni ijambo rusange ryurukurikirane rwaibikomoka kuri selilebyakozwe na reaction ya alkali selulose na etherifying agent mubihe bimwe. Nibicuruzwa amatsinda ya hydroxyl kuri selile ya macromolecules igice cyangwa asimbuwe rwose nitsinda rya ether. Ether ya selile ikoreshwa cyane mubijyanye na peteroli, ibikoresho byubaka, ibifuniko, ibiryo, imiti, nimiti ya buri munsi. Mubice bitandukanye, ibicuruzwa byo mu rwego rwa farumasi biri murwego rwo hagati no murwego rwohejuru rwinganda, hamwe nagaciro kongerewe. Bitewe nibisabwa byujuje ubuziranenge, umusaruro wa farumasi yo mu rwego rwa selulose ether nayo iragoye. Birashobora kuvugwa ko ubuziranenge bwibicuruzwa byo mu rwego rwa farumasi bishobora kwerekana ahanini imbaraga za tekinike yinganda za selile. Ubusanzwe selulose ether yongeweho nkibibuza, ibikoresho bya matrix hamwe nububyimbye kugirango ikore ibinini bya matrix irekura-irekuye, ibikoresho byo gutwika gastric-soluble, ibikoresho byo gutwika microcapsule bikomeza kurekurwa, ibikoresho bya firime yibiyobyabwenge, nibindi.

Sodium carboxymethyl selulose ：

Carboxymethyl selulose sodium (CMC-Na) nubwoko bwa selulose ether ifite umusaruro mwinshi nogukoresha mugihugu ndetse no mumahanga. Ni ionic selulose ether ikozwe mu ipamba no mu biti binyuze muri alkalisation na etherification hamwe na aside ya chloroacetic. CMC-Na ni imiti ikoreshwa cyane. Bikunze gukoreshwa nkibihuza imyiteguro ihamye, umubyimba, umubyimba, hamwe nu guhagarika ibikorwa byo gutegura amazi. Irashobora kandi gukoreshwa nka matrike yamazi yogukoresha hamwe nibikoresho bikora firime. Bikunze gukoreshwa nkibikoresho byamafirime bikomeza kurekurwa hamwe na tablet ya matrix irekuye mugihe cyo gutegura (kugenzura) gusohora.

Usibye sodium carboxymethylcellulose nkibikoresho bya farumasi, sodium ya croscarmellose irashobora kandi gukoreshwa nkibikoresho bya farumasi. Sodium ya Croscarmellose (CCMC-Na) nigicuruzwa kidashobora gukama amazi ya carboxymethylcellulose ikorana numukozi uhuza ubushyuhe runaka (40-80 ° C) hifashishijwe catalizike ya acide organique kandi igasukurwa. Nka agent ihuza, propylene glycol, anhydride ya succinic, anhydride yumugabo na adipic anhydride irashobora gukoreshwa. Sodium ya Croscarmellose ikoreshwa nkibintu bitandukanya ibinini, capsules na granules mugutegura umunwa. Yishingikiriza ku ngaruka za capillary no kubyimba kugirango isenyuke. Ifite compressible nziza nimbaraga zikomeye zo gusenyuka. Ubushakashatsi bwerekanye ko kubyimba kwa sodium ya croscarmellose mu mazi ari byinshi kuruta ibyangiritse nka sodium ya carmellose isimbuwe na selile na microcrystalline selile.

Methylcellulose ：

Methyl selulose (MC) ni ether ya selile idafite ionic imwe ikozwe mu ipamba no mu biti binyuze muri alkalisation na methyl chloride etherification. Methylcellulose ifite amazi meza cyane kandi ihamye murwego rwa pH2.0 ~ 13.0. Ikoreshwa cyane mubikoresho bya farumasi, kandi ikoreshwa mubinini bya sublingual, inshinge zo mu nda, imyiteguro y'amaso, capsules yo mu kanwa, guhagarika umunwa, ibinini byo munwa hamwe nimyiteguro yibanze. Byongeye kandi, mu myiteguro ihamye-irekura, MC irashobora gukoreshwa nka hydrophilique gel matrix itegura-gusohora, ibikoresho byo gutwika gastric-soluble, ibikoresho byo gutwika microcapsule bikomeza kurekurwa, ibikoresho bya firime yibiyobyabwenge, nibindi.

Hydroxypropyl methyl selulose ：

Hydroxypropyl methylcellulose (HPMC) ni selile ya ionic selulose ivanze ikozwe mu ipamba no mu biti binyuze muri alkalisation, okiside ya propylene na methyl chloride etherification. Ntabwo ari impumuro nziza, uburyohe, ntabwo ari uburozi, gushonga mumazi akonje kandi ikavangwa mumazi ashyushye. Hydroxypropyl methylcellulose ni selile ivanze ya ether ubwoko bwumusaruro, dosiye nubwiza byiyongereye vuba mubushinwa mumyaka 15 ishize. Ninimwe mu bikoresho bikoreshwa cyane mu bya farumasi mu gihugu no hanze yacyo. imyaka y'amateka. Kugeza ubu, ikoreshwa rya HPMC rigaragarira cyane cyane mu bintu bitanu bikurikira:

Imwe ni nkuguhuza no gutandukana. Nka binder, HPMC irashobora gutuma imiti yoroshye gutose, kandi irashobora kwaguka inshuro magana nyuma yo gufata amazi, bityo irashobora kuzamura cyane igipimo cyo gushonga cyangwa igipimo cyo kurekura ibinini. HPMC ifite ububobere bukomeye, bushobora kongera ububobere buke no kunoza igabanuka ryibikoresho fatizo byoroshye cyangwa byoroshye. HPMC ifite ubukonje buke irashobora gukoreshwa nka binder na disintegrant, kandi abafite ububobere buke barashobora gukoreshwa gusa nka binder.

Iya kabiri ni nkibikoresho bikomeza kandi bigenzurwa byo gutegura umunwa. HPMC ni ibikoresho bisanzwe bikoreshwa na hydrogel matrike mugutegura-kurekura. Icyiciro cyo hasi cyane (5-50mPa · s) HPMC irashobora gukoreshwa nka binder, viscosifier na agent ihagarika, hamwe nicyiciro cyo hejuru cyane (4000-100000mPa · s) HPMC irashobora gukoreshwa mugutegura ibikoresho bivanze Kubuza capsules, materix ya hydrogel kwagura-kurekura ibinini. HPMC irashonga mumazi ya gastrointestinal, ifite ibyiza byo kwikuramo neza, gutembera neza, ubushobozi bwo gupakira ibiyobyabwenge, hamwe nibiranga ibiyobyabwenge bitatewe na PH. Nibikoresho byingenzi bitwara hydrophilique muri sisitemu yo gutegura-kurekura kandi ikunze gukoreshwa nka materix ya Hydrophilique gel hamwe nibikoresho byo gutwikira imyiteguro irekuwe irekuwe, hamwe nibikoresho bifasha imyiteguro ireremba gastrica hamwe nogutegura-gusohora ibiyobyabwenge bya firime.

Iya gatatu ni nkibikoresho byo gutwika firime. HPMC ifite ibyiza byo gukora firime. Filime yakozwe nayo irasa, iragaragara kandi irakomeye, kandi ntabwo byoroshye gukomera mugihe cyo kuyikora. By'umwihariko ku biyobyabwenge byoroshye gukurura ubuhehere kandi bidahindagurika, kubikoresha nk'urwego rwo kwigunga birashobora guteza imbere cyane ibiyobyabwenge kandi bikarinda Filime ihindura ibara. HPMC ifite ibisobanuro bitandukanye bya viscosity. Niba byatoranijwe neza, ubuziranenge nigaragara ryibinini bisize bisumba ibindi bikoresho. Ubusanzwe kwibanda ni 2% kugeza 10%.

Iya kane ni nkibikoresho bya capsule. Mu myaka yashize, hamwe n’ibyorezo by’ibyorezo by’inyamaswa ku isi, ugereranije na gelatine capsules, capsules z’imboga zahindutse umukunzi mushya w’inganda zikora imiti n’ibiribwa. Pfizer yo muri Amerika yakuye neza HPMC mubihingwa karemano kandi itegura capsules yimboga za VcapTM. Ugereranije na gakondo ya gelatin hollow capsules, capsules yibihingwa bifite ibyiza byo guhuza n'imihindagurikire y'ikirere, nta ngaruka zo guhuza ibisubizo no guhagarara neza. Igipimo cyo kurekura ibiyobyabwenge kirahagaze neza, kandi itandukaniro ryabantu ni rito. Nyuma yo gusenyuka mumubiri wumuntu, ntabwo yinjizwa kandi irashobora gusohoka Ikintu gisohoka mumubiri. Kubijyanye nuburyo bwo guhunika, nyuma yumubare munini wibizamini, ntibishobora kuba byoroshye mu gihe cy’ubushyuhe buke, kandi imiterere y’igikonoshwa cya capsule iracyahagaze neza mu gihe cy’ubushyuhe bwinshi, kandi ibipimo bya capsules y’ibihingwa ntabwo bigira ingaruka ku bubiko bukabije; imiterere. Hamwe nogusobanukirwa kwabantu capsules yibihingwa no guhindura imyumvire yubuvuzi rusange mugihugu ndetse no hanze yarwo, isoko ryamasoko ya capsules iziyongera vuba.

Icya gatanu ni nkumukozi uhagarika. Gutegura ubwoko bwamazi yo guhagarikwa nuburyo bukoreshwa muburyo bwa dosiye yubuvuzi, aribwo buryo bwo gukwirakwiza heterogeneous aho imiti ikomeye idashobora gukwirakwizwa ikwirakwizwa mu buryo bwo gukwirakwiza amazi. Ihame rya sisitemu rigena ubuziranenge bwimyiteguro yo guhagarika. HPMC ikomatanya irashobora kugabanya ubukana-bwamazi hagati yimiterere, kugabanya ingufu zubusa zubutaka bwibice bikomeye, kandi bigahindura sisitemu yo gukwirakwiza heterogeneous. Numukozi mwiza wo guhagarika. HPMC ikoreshwa nkibyimbye kumaso yijisho, hamwe nibirimo 0.45% kugeza 1.0%.

Hydroxypropyl Cellulose ：

Hydroxypropyl selulose (HPC) ni selile ya ionic selile imwe ya ether ikozwe mu ipamba no mu biti binyuze muri alkalisation na propylene oxyde etherification. Ubusanzwe HPC irashobora gushonga mumazi ari munsi ya 40 ° C numubare munini wumuti wa polar, kandi imikorere yayo ijyanye nibiri mumatsinda ya hydroxypropyl hamwe nurwego rwa polymerisation. HPC irashobora guhuzwa nibiyobyabwenge bitandukanye kandi ifite inertia nziza.

Hydroxypropyl selulose isimbuwe cyane (L-HPC) ikoreshwa cyane nka tablet disintegrant na binder. -HPC irashobora kunoza ubukana n'umucyo wa tablet, kandi irashobora kandi gutuma tablet isenyuka vuba, kuzamura ubwiza bwimbere bwibinini, no kunoza ingaruka zo kuvura.

Hydroxypropyl selulose isimbuwe cyane (H-HPC) irashobora gukoreshwa nkumuhuza wibinini, granules, na granules nziza murwego rwa farumasi. H-HPC ifite imiterere myiza yo gukora firime, kandi firime yabonetse irakomeye kandi yoroheje, ishobora kugereranywa na plastike. Imikorere ya firime irashobora kurushaho kunozwa no kuvanga nibindi bikoresho bitarinda ubushuhe, kandi akenshi bikoreshwa nkibikoresho byo gutwikira firime kubinini. H-HPC irashobora kandi gukoreshwa nkibikoresho bya matrix kugirango itegure matrix ikomeza-irekura ibinini, pellet irekura-isohoka hamwe na tableti ebyiri-ikomeza-kurekura.

Hydroxyethyl selile

Hydroxyethyl selulose (HEC) ni selile ya ionic selile imwe ya ether ikozwe mu ipamba no mu biti binyuze muri alkalisation na etherifike ya okiside ya Ethylene. Mu rwego rwubuvuzi, HEC ikoreshwa cyane cyane mubyimbye, birinda colloidal, birinda, ikwirakwiza, stabilisateur, umukozi uhagarika, umukozi ukora firime nibikoresho bikomeza kurekurwa, kandi birashobora gukoreshwa kuri emulisiyo yibanze, amavuta, ibitonyanga byamaso, Amazi yo mu kanwa, ibinini bikomeye, capsule nubundi buryo bwa dosiye. Hydroxyethyl selulose yanditswe muri Pharmacopoeia yo muri Amerika / Imiterere yigihugu ya Amerika hamwe na Pharmacopoeia yu Burayi.

Ethyl selulose ：

Ethyl selulose (EC) nimwe mubikoreshwa cyane mumazi adashobora gushonga. EC ntabwo ari uburozi, butajegajega, budashonga mumazi, aside cyangwa alkali, kandi bigashonga mumashanyarazi nka Ethanol na methanol. Ibisanzwe bikoreshwa ni soluene / Ethanol nka 4/1 (uburemere) bivanze. EC ifite uburyo bwinshi bwo gukoresha ibiyobyabwenge byateguwe-gusohora, bikoreshwa cyane nk'abatwara, microcapsules, hamwe n'ibikoresho byo gukora firime byo gutegura-gusohora birambye, nk'ibikoresho bya tableti, ibifunga, hamwe n'ibikoresho byo gutwika firime, bikoreshwa nka firime ya matrise yo gutegura ubwoko butandukanye bwa matrix ikomeza-kurekura ibinini, ikoreshwa nkibikoresho bivanze kugirango itegure imyiteguro irambuye-irekura, pellet irekura-isohoka, kandi ikoreshwa nkibikoresho bifasha ibikoresho byo gutegura microcapsules irekura-irekura; irashobora kandi gukoreshwa cyane nkibikoresho byabatwara Kugirango hategurwe ibintu bikomeye; ikoreshwa cyane mubuhanga bwa farumasi nkibintu bikora firime hamwe nuburinzi bukingira, kimwe no guhuza no kuzuza. Nkaho ikingira ikingira ibinini, irashobora kugabanya ububobere buke bwibinini kandi bikarinda ibiyobyabwenge kutagira ingaruka kubushuhe, amabara no kwangirika; irashobora kandi gukora gel-gahoro gahoro gahoro, microencapsulate polymer, kandi igafasha kurekura ingaruka zibiyobyabwenge.