Kora intoki Sanitizer Gel ukoresheje HPMC kugirango usimbuze Carbomer

Gel isuku yintoki yabaye ikintu cyingenzi mubuzima bwacu bwa buri munsi, cyane cyane mugihe cyanduye COVID-19. Ikintu kigira uruhare runini mu isuku ya gel isanzwe ni inzoga, igira akamaro mu kwica bagiteri na virusi ku ntoki. Ariko, kugirango ukore gel, feri ikenewe kugirango habeho gel ihamye. Carbomer nikintu gikunze gukoreshwa mubyimba byogukora isuku ya gel, ariko birashobora kugorana kubituruka kandi yabonye ibiciro byiyongereye kubera icyorezo. Muri iki kiganiro, tuzaganira ku buryo bwo gukora intoki zogeza intoki ukoresheje Hydroxypropyl Methylcellulose (HPMC) nk'umusimbura wa karbomer.

Hydroxypropyl Methylcellulose (HPMC) ni selile ikomoka kuri selile ifite uburyo bwinshi bwo gukoresha, harimo nk'ibyimbye, binder, na emulifier. HPMC ni polymer-eruble polymer ishobora kubyimba amazi ashingiye kumazi, bigatuma iba uburyo bwiza bwa karbomer mumaboko ya sanitizer gel. HPMC nayo iraboneka byoroshye kandi ihendutse kuruta carbomer, bigatuma iba iyindi nzira ishimishije kubayikora.

Gukora intoki isuku ukoresheje HPMC, ibikenewe nibikoresho bikurikira:

Ibigize:

Inzoga ya Isopropyl (cyangwa Ethanol)
Hydrogen peroxide
Glycerin
Hydroxypropyl Methylcellulose (HPMC)
Amazi yamenetse

Ibikoresho:

Kuvanga igikombe
Kuvanga inkoni cyangwa kuvanga amashanyarazi
Gupima ibikombe n'ibiyiko
metero pH
Ibikoresho byo kubika intoki isuku

Intambwe ya 1: Gupima Ibigize Gupima ibintu bikurikira:

Inzoga ya Isopropyl (cyangwa Ethanol): 75% yubunini bwa nyuma
Hydrogen peroxide: 0,125% yubunini bwa nyuma
Glycerin: 1% yubunini bwa nyuma
HPMC: 0.5% yubunini bwanyuma
Amazi yamenetse: ingano isigaye

Kurugero, niba ushaka gukora 100ml yintoki zogukora isuku, wakenera gupima:

Inzoga ya Isopropyl (cyangwa Ethanol): 75ml
Hydrogen peroxide: 0.125ml
Glycerin: 1ml
HPMC: 0.5ml
Amazi yamenetse: 23.375ml

Intambwe ya 2: Kuvanga Ibigize Kuvanga inzoga ya isopropyl (cyangwa Ethanol), hydrogen peroxide, na glycerine hamwe mukibindi kivanze. Koresha imvange kugeza ihujwe neza.

Intambwe ya 3: Ongeramo HPMC Buhoro buhoro ongeramo HPMC muruvange mugihe ukomeje. Ni ngombwa kongeramo HPMC buhoro kugirango wirinde guhuzagurika. Komeza kubyutsa kugeza HPMC itatanye rwose kandi imvange yoroshye.

Intambwe ya 4: Ongeramo Amazi Ongeramo amazi yatoboye kuvanga mugihe ukomeje. Komeza kubyutsa kugeza igihe ivanze rihujwe neza.

Intambwe ya 5: Reba pH Reba pH yuruvange ukoresheje metero pH. PH igomba kuba hagati ya 6.0 na 8.0. Niba pH iri hasi cyane, ongeramo urugero rwa hydroxide ya sodium (NaOH) kugirango uhindure pH.

Intambwe ya 6: Kuvanga Ubundi Kongera kuvanga kugirango wizere ko ibintu byose byahujwe byuzuye.

Intambwe 7: Kwimurira muri kontineri Hindura intoki isuku yintoki kubintu byabitswe.

Ibiganza bya sanitizeri byavuyemo bigomba kugira uburyo bworoshye, bumeze nka gel byoroshye gukoreshwa mumaboko. HPMC ikora nkibyimbye kandi ikora gel ihamye nka gel ihamye, isa na karbomer. Gel isuku yintoki yavuyemo igomba kuba ingirakamaro mukwica bagiteri na virusi kumaboko, kimwe nubucuruzi bwintoki ziboneka mubucuruzi.

ibikorwa byo gukora (GMP) ni umurongo ngenderwaho n'amahame yemeza ubuziranenge n'umutekano byibicuruzwa bikoreshwa mu bya farumasi, harimo na gel isukura intoki. Aya mabwiriza akubiyemo ibintu bitandukanye byuburyo bwo gukora, harimo abakozi, amazu, ibikoresho, inyandiko, umusaruro, kugenzura ubuziranenge, no gukwirakwiza.

Iyo ukora intoki isukura ukoresheje HPMC cyangwa ikindi kintu icyo ari cyo cyose kibyimba, ni ngombwa gukurikiza amabwiriza ya GMP kugirango ubuziranenge n'umutekano byibicuruzwa. Bimwe mubyingenzi byingenzi bya GMP bigomba gukurikizwa mugihe cyo gukora intoki zogukora intoki zirimo:

Abakozi: Abakozi bose bagize uruhare mubikorwa byo gukora bagomba guhugurwa muburyo bukwiye kandi bujuje inshingano zabo. Bagomba kandi kumenya amabwiriza ya GMP kandi bakayakurikiza byimazeyo.
Ahantu: Uruganda rukora rugomba kuba rufite isuku, rukabungabungwa neza, kandi rugenewe gukumira umwanda. Ikigo kigomba kuba gifite umwuka uhagije hamwe n’itara, kandi ibikoresho byose bigomba guhinduka neza kandi bikemezwa.
Ibikoresho: Ibikoresho byose bikoreshwa mubikorwa byo gukora bigomba guhora bisukurwa kandi bikabungabungwa kugirango birinde umwanda. Ibikoresho bigomba kandi kwemezwa kugirango bikore neza kandi bitange ibisubizo bihamye.
Inyandiko: Ibikorwa byose byo gukora bigomba kuba byanditse neza, harimo ibyiciro, ibyakozwe bisanzwe (SOPs), hamwe nubugenzuzi bwubuziranenge. Inyandiko zigomba kuba zuzuye kandi zuzuye kugirango zemeze gukurikiranwa no kubazwa.
Umusaruro: Inzira yo gukora igomba gukurikiza inzira isobanuwe kandi yemewe yemeza ubuziranenge nubuziranenge bwibicuruzwa. Ibikoresho byose bikoreshwa mubikorwa byo gukora bigomba kumenyekana neza, kugenzurwa, no kubikwa.
Kugenzura ubuziranenge: Ingamba zo kugenzura ubuziranenge zigomba kuba zihari kugirango ibicuruzwa byanyuma byujuje ibisabwa. Igenzura ryiza rigomba kubamo ibizamini biranga, ubuziranenge, imbaraga, nibindi bipimo bifatika.
Ikwirakwizwa: Igicuruzwa cyarangiye kigomba gupakirwa neza, gushyirwaho ikimenyetso, no kubikwa kugirango wirinde kwanduza no gukomeza ubusugire bwacyo. Igikorwa cyo gukwirakwiza kigomba kuba cyanditse neza, kandi ibyoherejwe byose bigomba gukurikiranwa neza no kugenzurwa.

Mugukurikiza aya mabwiriza ya GMP, abayikora barashobora kwemeza ko ibicuruzwa byabo byogusukura intoki bifite ubuziranenge kandi bifite umutekano kugirango bikoreshwe. Aya mabwiriza kandi afasha kumenya niba kwizerwa no kwizerwa mubikorwa byo gukora, ari ngombwa mugukemura ikibazo gikenewe cyogukora isuku yintoki mugihe cya COVID-19.

Mu gusoza, Hydroxypropyl Methylcellulose (HPMC) irashobora gukoreshwa mugusimbuza karbomer mumaboko ya sanitizer gel. HPMC nigiciro cyoroshye kandi cyoroshye kuboneka ubundi bushobora gutanga ibintu bisa nkibintu bya karbomer. Iyo ukora intoki zogukoresha intoki ukoresheje HPMC, ni ngombwa gukurikiza amabwiriza ya GMP kugirango umenye neza umutekano numutekano wibicuruzwa. Mugukurikiza aya mabwiriza, abayikora barashobora gukora gel isuku yintoki ifite akamaro mukwica bagiteri na virusi kumaboko, mugihe kandi birinda umutekano wumukoresha wa nyuma.

Igihe cyo kohereza: Werurwe-18-2023