Hydroxypropyl methylcellulose ikoresha mubinini

Hydroxypropyl methylcellulose (HPMC) ni ibintu bisanzwe bikoreshwa mu miti, harimo na tableti. HPMC ni polymer ishingiye kuri selile ikemuka mumazi kandi ifite imitungo itandukanye ituma igira akamaro mugutegura ibinini. Iyi ngingo izaganira ku miterere ya HPMC n’imikoreshereze yayo itandukanye mu gukora tablet.

Ibyiza bya HPMC:

HPMC ni hydrophilique polymer ishobora gukoreshwa nka binder, kubyimbye, stabilisateur, na emulifier. Ifite uburemere buke bwa molekuline hamwe nu rwego rwo hejuru rwo gusimbuza (DS), bigira ingaruka ku gukemuka kwayo. HPMC irashobora gushonga mumazi cyangwa inzoga, ariko ntishobora gushonga mumashanyarazi menshi. Ntabwo kandi ari uburozi, budatera uburakari, kandi butari allerge, bigatuma ihitamo neza kubikoresho bya farumasi.

Imikoreshereze ya HPMC mu bisate:

1. Binder:

HPMC isanzwe ikoreshwa nka binder mugutegura ibinini. Yongewe kuri tablet granules kugirango ifate hamwe kandi irinde gutandukana. HPMC irashobora gukoreshwa wenyine cyangwa ifatanije nizindi binders, nka microcrystalline selulose (MCC), kugirango ibinini bikomere kandi byoroshye.

2. Gutandukana:

HPMC irashobora kandi gukoreshwa nkigice cyo gutandukanya ibinini. Disintegrants yongewe kubinini kugirango ibafashe gutandukana no gushonga vuba mumitsi yigifu. HPMC ikora nk'idacika intege mu kubyimba mu mazi no gukora imiyoboro y'amazi yinjira mu gisate. Ibi bifasha gutandukanya ibinini no kurekura ibintu bikora.

3. Kurekurwa kugenzurwa:

HPMC ikoreshwa mugutegekanya-kurekura ibinini byateguwe kugirango bigenzure irekurwa ryibintu bikora. HPMC ikora gel igizwe na tablet, igenzura irekurwa ryibintu bikora. Ubunini bwurwego rwa gel burashobora kugenzurwa muguhindura DS ya HPMC, bigira ingaruka kumyuka no gukomera kwa polymer.

4. Gufata amashusho:

HPMC nayo ikoreshwa nkumukozi wo gutwika firime muburyo bwa tablet. Gufata amafirime ni inzira yo gukoresha polymer yoroheje kurwego rwa tablet kugirango urusheho kugaragara, kurinda ubushuhe, no guhisha uburyohe bwarwo. HPMC irashobora gukoreshwa yonyine cyangwa ifatanije nibindi bikoresho bifata amashusho, nka polyethylene glycol (PEG), kugirango itezimbere imiterere ya firime.

5. Umukozi uhagarikwa:

HPMC nayo ikoreshwa nkumukozi uhagarika muburyo bwo gutemba. Irashobora gukoreshwa muguhagarika ibice bitangirika mumazi kugirango habeho ihagarikwa rihamye. HPMC ikora ikora urwego rukingira ibice, ikabuza guhuriza hamwe no gutura munsi yikintu.

Umwanzuro:

Hydroxypropyl methylcellulose ni polymer itandukanye ifite imikoreshereze itandukanye muburyo bwa tablet. Irashobora gukoreshwa nka binder, disintegrant, igenzurwa-gusohora, umukozi wa firime, hamwe nuwashinzwe guhagarika. Ibintu bidafite uburozi, ntibitera uburakari, kandi bitari allergique bituma ihitamo neza kubikoresho bya farumasi. Imiterere ya HPMC irashobora guhindurwa muguhindura urwego rwo gusimburwa, ikagira polymer yoroheje ishobora gukoreshwa muburyo butandukanye bwibinini.