Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose(HPMC) ni inkomoko ya selile ikoreshwa cyane mu nganda zitandukanye, harimo imiti, ibiryo, ubwubatsi, no kwita ku muntu ku giti cye. Ikozwe muburyo bwa chimique ihindura selile binyuze muri etherification, ikubiyemo kwinjiza hydroxypropyl na methyl mumatsinda ya selile.

HPMC ni ifu yera-yera-ifu idafite impumuro idashonga mumazi kandi ikora igisubizo gisobanutse neza. Ifite imitungo itandukanye ituma igira akamaro mubikorwa bitandukanye. Kurugero, ni umubyimba, stabilisateur, na emulisiferi mubicuruzwa byibiribwa. Mu bwubatsi, ikoreshwa nkibikoresho byo kubika amazi muri sima na minisiteri kugirango bitezimbere imikorere kandi birinde gucika. Mubicuruzwa byawe bwite, bikoreshwa nkibyimbye na emulisiferi mumavuta yo kwisiga, amavuta, nibindi bicuruzwa.

Muri farumasi, HPMC ikoreshwa nka binder, disintegrant, kandi igenzurwa-kurekura ibinini na capsules. Irakoreshwa kandi nkumukozi uhagarika mumashanyarazi kandi nkamavuta mumavuta na cream. HPMC nikintu cyemewe cyane munganda zimiti kubera ibinyabuzima bihuza, umutekano, nuburozi buke.

HPMC ifite amanota menshi hamwe ninzego zitandukanye zijimye, zagenwe numubare wimibare. Umubare munini, niko kwiyongera. Amanota ya HPMC kuva mubukonje buke (5 cps) kugeza hejuru cyane (100.000 cps). Ubukonje bwa HPMC ni ikintu gikomeye mu kumenya imiterere n'imikorere.

Imikoreshereze ya HPMC mu miti yiyongereye mu myaka yashize bitewe n’imiterere yayo myinshi ndetse n’uburyo bukenewe bwo gutanga imiti igezweho. Hydrogels ishingiye kuri HPMC yakoreshejwe muri sisitemu yo gutanga ibiyobyabwenge bitewe na biocompatibilité, irekurwa, hamwe na mucoadhesive. Ibinini bishingiye kuri HPMC nabyo byakozwe hifashishijwe imitungo yahinduwe-irekura itanga imiti igamije no kunoza iyubahirizwa ry’abarwayi.

Ariko, HPMC ntabwo ifite aho igarukira. Ifite ubushobozi buke bwo gukemura ibibazo kandi byumva impinduka za pH. Byongeye kandi, ifite ubushyuhe buke kandi irashobora gutakaza ubukonje bwayo hejuru. Izi mbogamizi zatumye habaho iterambere ry’ibindi bikomoka kuri selile, nka hydroxyethyl selulose (HEC) na carboxymethyl selulose (CMC), byateje imbere imitungo hamwe n’urwego rwagutse.

Mu gusoza, HPMC ni inkomoko ya selile itandukanye ikoreshwa cyane mu nganda zitandukanye, cyane cyane mu bya farumasi. Imiterere yihariye, harimo na biocompatibilité, umutekano, hamwe nuburozi buke, bituma iba icyamamare mugutegura ibiyobyabwenge. Sisitemu yo gutanga imiti ishingiye kuri HPMC yerekanye amasezerano yo kuzamura imikorere y’ibiyobyabwenge no kubahiriza abarwayi. Nyamara, aho igarukira mu gukemura no kwiyumvisha pH byatumye habaho iterambere ry’ibindi bikomoka kuri selile bifite imiterere myiza.