HPMC ikoreshwa mumatonyanga y'amaso

Hydroxypropyl methylcellulose (HPMC) ni polymer ikoreshwa cyane mu nganda zimiti, cyane cyane mugutezimbere imiti y’amaso nko gutonyanga amaso. Amaso y'amaso akoreshwa mu kuvura ibintu bitandukanye nk'amaso yumye, glaucoma, na allergie. HPMC irashobora gukoreshwa mubitonyanga byamaso nkibikoresho byongera ububobere, umukozi wa mucoadhesive, hamwe nuburinzi. Muri iyi ngingo, tuzasesengura imikoreshereze ya HPMC mu bitonyanga by'amaso ku buryo burambuye.

Umukozi wongerera imbaraga

Imwe mu nshingano zibanze za HPMC mu bitonyanga by'amaso ni ukongera ububobere bwabo. Viscosity ni ikintu cyingenzi muburyo bwo kuvura amaso kuko bifasha kwemeza ko formulaire iguma hejuru ya ocular ndende bihagije kugirango itange inyungu zo kuvura. Ubwiza bwibisubizo bya HPMC biterwa nuburemere bwa molekuline ya polymer nurwego rwo gusimburwa. HPMC ibisubizo bifite uburemere buke bwa molekile hamwe nurwego rwo gusimbuza bifite ububobere buke.

HPMC niyongera ubwiza bwimyororokere kumatonyanga yijisho kuko itanga ingaruka zihoraho-kurekura bitewe nuburyo bukora gel. Gele ikorwa na HPMC mu bitonyanga by'amaso yongerera igihe cyo guhura hagati yibiyobyabwenge nijisho, bityo bigatuma imiti ikora neza. Byongeye kandi, ibisubizo bya HPMC ntabwo bihindura icyerekezo, bigatuma biba amahitamo meza kumaso.

Mucoadhesive agent

Urundi ruhare rukomeye rwa HPMC mumatonyanga yijisho ni micoadhesive. HPMC ifitanye isano ryinshi na mucus membrane, kandi kuyikoresha mumatonyanga y'amaso birashobora gufasha kongera igihe cyo gutura kwa formulaire hejuru ya ocular. Ibi ni ingirakamaro cyane mu kuvura syndrome yumaso yumye, aho kumara igihe kinini uhura nibishobora gufasha kugabanya ibimenyetso byumye no kutamererwa neza.

Imiterere ya mucoadhesive ya HPMC iterwa na hydrogène ihuza imikoranire na mucin glycoproteine. Mucin glycoproteine ​​nibice byingenzi bigize ocular surface mucus layer, ikora nkinzitizi yo gukingira. HPMC irashobora kwizirika kumitsi kandi ikongerera igihe cyo guhura kwifumbire hejuru ya ocular.

Umukozi urinda

Usibye kuba yongera ubwiza bwayo hamwe na mucoadhesive, HPMC ikoreshwa kandi nk'uburinzi mu bitonyanga by'amaso. Ubuso bwa ocular bushobora kwangirika kubintu bituruka hanze nka imirasire ya UV, umwanda, numwuka wumye. HPMC irashobora gukora firime ikingira hejuru ya ocular ishobora gufasha kurinda amaso ibyo bintu byangiza.

Ibintu birinda HPMC biterwa no gukora geli imeze nka gel hejuru ya ocular. Uru rupapuro rukora nkinzitizi yumubiri ishobora gufasha kwirinda kwinjiza ibintu byangiza mumaso. HPMC irashobora kandi gufasha gutuza hejuru ya ocular no kugabanya ibimenyetso byo kurakara.

Umwanzuro

Mu gusoza, HPMC ni polymer itandukanye isanga ikoreshwa cyane mugutezimbere imiti y'amaso, cyane cyane ibitonyanga by'amaso. HPMC irashobora kunoza ubwiza bwibitonyanga byamaso, bishobora gufasha kongera igihe cyo guhura kwabo hejuru yubuso no kunoza imikorere. Imiterere ya HPMC ya mucoadhesive irashobora gufasha kongera igihe cyo gutura kwa formulaire hejuru ya ocular, bigatuma ihitamo neza kuvura syndrome yumaso yumye. HPMC irashobora kandi kurinda ubuso bwa ocular ibintu byangiza hanze mugukora urwego rukingira. Guhitamo witonze icyiciro gikwiye cya HPMC hamwe nibitekerezo birashobora gufasha kwemeza imikorere myiza no guhuza mumikorere y'amaso.