HPMC E15 yo gutwikira ibiyobyabwenge

Hydroxypropyl methylcellulose (HPMC) ni polymer ikoreshwa cyane munganda zimiti. HPMC ni amazi ashonga, adakomoka kuri ionic selulose ikomoka kuri selile. Imiterere ya HPMC irashobora kugenzurwa muguhindura urwego rwo gusimbuza (DS), urugero rwa polymerisation (DP), hamwe nikigereranyo cya hydroxypropyl na methyl. HPMC E15 ni icyiciro cya HPMC hamwe na DS ya 0.15 hamwe n'ubukonje bwa cps 15 kuri 20 ° C.

HPMC E15 isanzwe ikoreshwa nkibintu bidasanzwe mu nganda zimiti kubera imiterere yihariye. Kimwe mu byiza byingenzi bya HPMC E15 nubushobozi bwayo bwo gukora firime ikomeye, yoroheje, kandi iboneye. Iyi mitungo ituma ihitamo neza gukoreshwa mugukoresha ibiyobyabwenge. HPMC E15 ikunze gukoreshwa nkigikoresho cyo gukora firime mu mwenda wa enteric, wagenewe kurinda ibiyobyabwenge ibidukikije bya acide yo mu gifu no kubirekura ahantu hashobora kuba alkaline yo mu mara mato.

Imiterere ya firime ya HPMC E15 irashobora kandi gukoreshwa mugutezimbere uburyohe no kugaragara kumiterere ya dosiye. HPMC E15 irashobora gukoreshwa muguhisha uburyohe bukabije bwibiyobyabwenge bimwe na bimwe no kunoza uburyohe. HPMC E15 irashobora kandi gukoreshwa mugutanga ubuso bwuzuye, buringaniye kubinini na capsules, bigatuma bishimisha abarwayi.

Usibye imiterere ya firime, HPMC E15 nayo ihuza neza kandi ikabyimbye. HPMC E15 irashobora gukoreshwa mugutezimbere imitekerereze yifu yifu, kuborohereza kwikuramo ibinini. HPMC E15 irashobora kandi gukoreshwa mugutezimbere uburinganire bwibinini, kwemeza ko buri kibaho kirimo umubare uhoraho wibikoresho bya farumasi ikora (API).

HPMC E15 nayo irahagaze neza imbere ya acide, base, nu munyu, bigatuma iba umukandida mwiza wo gukoresha muburyo butandukanye bwa pH. Uyu mutungo wemerera gukoresha HPMC E15 muri sisitemu zitandukanye zo gutanga ibiyobyabwenge, harimo no gukomeza kurekura. HPMC E15 irashobora gukoreshwa mugucunga irekurwa ryibiyobyabwenge biva muburyo bukomeye nka tableti na capsules. Muguhindura ubunini bwa HPMC E15, igipimo cyo kurekura imiti kirashobora kugenzurwa.

Mugihe ukoresheje HPMC E15 muburyo bwo gufata imiti, ni ngombwa gusuzuma imikoranire ishobora kuba hamwe nibindi bikoresho hamwe nibikoresho bya farumasi (API). HPMC E15 irashobora gukorana nibindi bikoresho, bigatera impinduka mumiterere yumubiri. HPMC E15 irashobora kandi gukorana na API, ishobora kugira ingaruka kuri bioavailable hamwe nigipimo cyo kurekura. Niyo mpamvu, ni ngombwa gusuzuma witonze guhuza HPMC E15 hamwe nibindi bicuruzwa hamwe na API mbere yo gukora dosiye.

Usibye gukoreshwa mu nganda zimiti, HPMC E15 ikoreshwa no mubindi bikorwa bitandukanye. HPMC E15 ikoreshwa mu nganda zibiribwa nkibyimbye, stabilisateur, na emulifier. Irakoreshwa kandi mubikorwa byo kwita kubantu kugiti cyabo no kubyibuha no kwisiga mumavuta yo kwisiga, shampo, nibindi bicuruzwa byo kwisiga.

Mu gusoza, HPMC E15 ni polymer itandukanye hamwe nibikorwa byinshi mubikorwa bya farumasi. Imiterere yihariye, harimo ubushobozi bwo gukora firime, guhuza no kubyimba, gutuza muburyo butandukanye bwa pH, hamwe nubushobozi bwo kugenzura irekurwa ryibiyobyabwenge, bituma iba umukandida mwiza muri sisitemu zitandukanye zo gutanga ibiyobyabwenge. Ariko, ni ngombwa gusuzuma witonze guhuza HPMC E15 hamwe nibindi bicuruzwa hamwe na API mbere yo gukora dosiye.