Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mubikorwa bitandukanye birimo imiti, ibiryo nubwubatsi. Imwe mu miterere yingenzi ni ukubika amazi, bigira uruhare runini mukumenya imikorere yayo mubikorwa bitandukanye.
1 Intangiriro:
Hydroxypropylmethylcellulose (HPMC) ni polymer ishingiye kuri selile ikomoka kuri selile naturel. Yakwegereye ibitekerezo kubushobozi bwayo buhebuje bwo gukora firime, ibintu bifatika kandi cyane cyane, bigumana amazi. Ubushobozi bwo gufata amazi ya HPMC nikintu gikomeye mubikorwa nkibikoresho byubwubatsi, imiti yimiti, nibiribwa.
2. Akamaro ko gufata amazi muri HPMC:
Gusobanukirwa imiterere yo gufata amazi ya HPMC ningirakamaro mugutezimbere imikorere yayo mubikorwa bitandukanye. Mu bikoresho byubwubatsi, itanga neza neza kandi ikora neza ya minisiteri na plaster. Muri farumasi, bigira ingaruka kumwirondoro wo kurekura ibiyobyabwenge, no mubiribwa, bigira ingaruka kumiterere no mubuzima bwubuzima.
3. Ibintu bigira ingaruka ku gufata amazi ：
Ibintu byinshi bigira ingaruka kubushobozi bwo gufata amazi ya HPMC, harimo uburemere bwa molekile, urugero rwo gusimbuza, ubushyuhe, hamwe nubunini. Gusobanukirwa nibi bintu nibyingenzi mugushushanya ubushakashatsi bwerekana neza uko ibintu bimeze kwisi.
4. Uburyo busanzwe bwo kugerageza gufata amazi:
Uburyo bwa Gravimetric:
Gupima ingero za HPMC mbere na nyuma yo kwibizwa mu mazi.
Kubara ubushobozi bwo gufata amazi ukoresheje formula ikurikira: Igipimo cyo gufata amazi (%) = [(Uburemere nyuma yo koga - Uburemere bwambere) / Uburemere bwambere] x 100.
Igipimo cyo kubyimba:
Ubwiyongere bw'ubunini bwa HPMC nyuma yo kwibizwa mu mazi bwapimwe.
Igipimo cyo kubyimba (%) = [(ingano nyuma yo kwibizwa - ingano yambere) / ingano yambere] x 100.
Uburyo bwa Centrifugation:
Centrifuge ivanze rya HPMC hanyuma upime ingano y'amazi yagumanye.
Igipimo cyo gufata amazi (%) = (ubushobozi bwo gufata amazi / ubushobozi bwamazi yambere) x 100.
Nuclear Magnetic Resonance (NMR):
Imikoranire hagati ya HPMC na molekile yamazi yakozwe hakoreshejwe NMR spectroscopy.
Kunguka ubumenyi bwimpinduka zo murwego rwa HPMC mugihe cyo gufata amazi.
5. Intambwe zigeragezwa:
Icyitegererezo:
Menya neza ko ingero za HPMC zihagarariye porogaramu igenewe.
Kugenzura ibintu nkubunini bwibice hamwe nubushuhe.
Ikizamini cy'ibiro:
Gupima neza icyitegererezo HPMC yapimwe.
Shira icyitegererezo mumazi mugihe cyagenwe.
Icyitegererezo cyumye kandi uburemere bwongeye gupimwa.
Kubara kubika amazi.
Ibipimo byerekana kwaguka:
Gupima ingano yambere ya HPMC.
Shira icyitegererezo mumazi hanyuma upime ingano yanyuma.
Kubara icyerekezo cyo kwaguka.
Ikizamini cya Centrifuge:
Kuvanga HPMC n'amazi hanyuma wemere kuringaniza.
Centrifuge ivanze hanyuma upime ingano y'amazi yagumishijwe.
Kubara kubika amazi.
Isesengura rya NMR:
Gutegura icyitegererezo cya HPMC-isesengura rya NMR.
Gisesengura impinduka ziterwa na chimique nuburemere bwimpinga.
Guhuza amakuru ya NMR hamwe nuburyo bwo kubika amazi.
6. Isesengura ryamakuru no gusobanura:
Sobanura ibisubizo byabonetse hamwe na buri buryo, urebye ibisabwa byihariye bisabwa. Gereranya amakuru kuva muburyo butandukanye kugirango usobanukirwe byimazeyo imyitwarire yo gufata amazi ya HPMC.
7. Ibibazo n'ibitekerezo:
Muganire ku mbogamizi zishobora kugeragezwa mu gufata amazi, nko guhinduka mu ngero za HPMC, ibidukikije, ndetse no gukenera ubuziranenge.
8. Umwanzuro:
Ibyagaragaye mu ncamake hamwe n’akamaro ko gusobanukirwa n’imiterere y’amazi ya HPMC kugirango ikoreshwe neza mu nganda zitandukanye.
9.Icyerekezo kizaza:
Iterambere rishoboka muburyo bwo gupima nubuhanga byaganiriweho kugirango turusheho gusobanukirwa imiterere yo gufata amazi ya HPMC.
Igihe cyo kohereza: Ukuboza-11-2023