Hydroxypropylmethylcellulose (HPMC) ni selile ya selile ikoreshwa cyane mu nganda nyinshi nka farumasi, amavuta yo kwisiga, ibiryo, nubwubatsi. Bitewe nuburyo bwinshi nibintu byingirakamaro, HPMC yabaye ikintu gikunzwe muburyo butandukanye. Kugeza ubu, hari ubwoko butandukanye bwa HPMCs ku isoko, buri kimwe gifite imitungo yihariye na porogaramu.
HPMC ni polymer ya selile yahinduwe mumashanyarazi yabonetse mugukora selile na methyl chloride na okiside ya propylene. Iyi reaction itangiza amatsinda ya methyl na hydroxypropyl mumiterere ya selile, ikora amazi-ashonga, adafite ionic na polymer ikora cyane. Nyamara, ubwoko butandukanye bwa HPMC bufite impamyabumenyi zitandukanye zo gusimbuza (DS) ya methyl na hydroxypropyl, bigena imiterere yumubiri na chimique.
Mubisanzwe, ibicuruzwa bya HPMC byashyizwe mubikorwa ukurikije ubwiza nagaciro ka DS. Viscosity numutungo wingenzi wa HPMC kuko igira ingaruka kubicuruzwa, ubushobozi bwo gukora firime nubushobozi bwo kubyimba. Kurundi ruhande, agaciro ka DS kagena urwego rwo gusimbuza polymer bityo urugero rwa hydrophobicity yubwoko bwa HPMC. Kubwibyo, ubwoko butandukanye bwa HPMC bukomoka muburyo butandukanye mubwiza bwabo na DS. Hasi nubwoko busanzwe bwa HPMC nuburyo butandukanye.
1. Icyiciro gisanzwe HPMC
Icyiciro rusange HPMC ifite methyl DS kuva kuri 0.8 kugeza 2.0 na hydroxypropyl DS kuva kuri 0.05 kugeza 0.3. Ubu bwoko bwa HPMC buraboneka murwego runini rwicyiciro cya viscosity kuva 3cps kugeza 200.000cps. Icyiciro rusange HPMC ifite imbaraga zo gukemura neza mumazi kandi ikora ibisubizo bisobanutse, bigatuma ikoreshwa muburyo butandukanye mubiribwa, imiti nubuvuzi bwo kwisiga. HPMCs isanzwe ikoreshwa nkabakora firime, kubyimbye, emulisiferi na stabilisateur mubiribwa no kwisiga.
2. Gusimbuza hasi HPMC
HPMC isimbuwe nkeya ifite urwego rwo hasi rwo gusimbuza methyl na hydroxypropyl kuruta icyiciro cya HPMC gisanzwe. Ubu bwoko bwihariye bwa HPMC bufite methyl DS kuva kuri 0.2 kugeza 1.5 na hydroxypropyl DS kuva kuri 0.01 kugeza 0.2. Ibicuruzwa bike byasimbuwe HPMC bifite ubukonje buke, mubisanzwe hagati ya 3-400cps, kandi birwanya cyane umunyu na enzymes. Iyi mitungo ituma HPMC isimburwa gake kubicuruzwa byibiribwa nkamata, imigati nibikomoka ku nyama. Byongeye kandi, HPMC isimbuwe cyane nayo ikoreshwa nkibikoresho, bisenya kandi byangiza ibinini mu nganda zimiti.
3. Gusimbuza cyane HPMC
Urwego rwo hejuru rwo gusimbuza HPMC ifite urwego rwo hejuru rwo gusimbuza methyl na hydroxypropyl kuruta urwego rusanzwe rwa HPMC. Ubu bwoko bwa HPMC bufite methyl DS iri hagati ya 1.5 na 2.5 na hydroxypropyl DS iri hagati ya 0.1 na 0.5. Ibicuruzwa byasimbuwe cyane HPMC bifite ubukonje bwinshi, kuva kuri 100.000cps kugeza 200.000cps, kandi bifite uburyo bukomeye bwo kubika amazi. Iyi mitungo ituma HPMC isimburwa cyane kugirango ikoreshwe mu bwubatsi, nkibicuruzwa bishingiye kuri sima, ibifuniko hamwe n’ibiti. HPMC isimbuwe cyane nayo ikoreshwa nka binder, kubyimba no kurekura mubikorwa bya farumasi.
4. Methoxy-Ethoxy HPMC
Methoxy-Ethoxy HPMC ni ubwoko bwateguwe bwa HPMC hamwe nurwego rwo hejuru rwo gusimbuza ethoxy. Amatsinda ya ethoxy yongerera hydrophobicity ya HPMC, bigatuma idashonga mumazi kuruta icyiciro cya HPMC gisanzwe. Hamwe na methyl DS iri hagati ya 1.5 na 2,5 na ethoxy DS iri hagati ya 0.4 na 1.2, mikorobe-ethoxy HPMC nibyiza gukoreshwa mubicuruzwa bishingiye kumavuta nka cosmetike, amarangi hamwe no gutwikira. Ubu bwoko bwa HPMC bugizwe na firime ihamye kandi imwe itanga neza, irabagirana kurangiza kubicuruzwa byanyuma.
5. HPMC
Granular HPMC ni ubwoko bwa HPMC ifite ingano ntoya, mubisanzwe hagati ya microni 100-200. Granular HPMC ikoreshwa munganda zimiti nkibikoresho bya tablet, bidahwitse kandi bihoraho. Ingano ntoya ya HPMC ituma habaho gukwirakwiza ibintu, bivamo ibicuruzwa bihamye kandi byizewe. Granular HPMC ifite methyl DS iri hagati ya 0.7 na 1.6 na hydroxypropyl DS iri hagati ya 0.1 na 0.3.
Hydroxypropylmethylcellulose (HPMC) ni polymer ikora cyane hamwe nibikorwa byinshi mubikorwa bitandukanye. Ubwoko bwa HPMC bushyirwa mubikorwa ukurikije viscosity na DS agaciro, bigena imiterere yumubiri na chimique. Icyiciro gisanzwe HPMC, gusimbuza hasi HPMC, gusimbuza cyane HPMC, imikorerexyethoxy HPMC na granular HPMC nubwoko busanzwe bwa HPMC. Gusobanukirwa itandukaniro riri hagati yubwoko bizemerera abashinzwe gukoresha ubushobozi bwuzuye bwa HPMCs kugirango babone umusaruro mwiza kandi ukomeye.
Igihe cyo kohereza: Nzeri-06-2023