Hydroxypropylmethylcellulose (HPMC) ni polymer synthique ikomoka kuri selile. Nkibyimbye, emulisiferi na stabilisateur, ikoreshwa cyane mubuvuzi, ibiryo ninganda zo kwisiga. HPMC ikoreshwa kandi mubikoresho byubwubatsi nka sima, minisiteri na gypsumu mugutezimbere imikorere no gufata amazi. Muri iki kiganiro, tuzaganira ku musaruro wa HPMC no kuyishyira mu bikorwa mu nganda zitandukanye.
Umusaruro wa HPMC
HPMC ihindurwamo reaction ya selile hamwe na oxyde ya propylene na methyl chloride mugihe cya alkaline. Inzira ikubiyemo intambwe zikurikira:
Intambwe ya 1: Kuvura alkaline ya selile
Cellulose ivurwa hakoreshejwe igisubizo cya caustic hydroxide ya sodium kugirango ihindurwe na selile alkaline. Ubu buvuzi butuma amatsinda ya hydroxyl ya selilose arushaho gukora, byorohereza reaction nyuma.
Intambwe ya 2: Igisubizo hamwe na Oxide ya Propylene
Mu ntambwe ikurikiraho, okiside ya propylene yongerwa kuri selile ya alkaline munsi yubushyuhe bugenzurwa nubushyuhe. Igisubizo gikozwe imbere ya catalizator nka amine ya gatatu cyangwa hydroxide ya alkali. Okiside ya Propylene ifata hamwe na hydroxyl matsinda ya selile kugirango ikore hydroxypropyl selile.
Intambwe ya 3: Quaternisation hamwe na Methyl Chloride
Hydroxypropylcellulose noneho yashizwemo methyl chloride kugirango ikore HPMC. Imyitwarire ikorwa mubihe bya alkaline, kandi urwego rwa quaternisation rushobora kugenzurwa no guhindura urugero rwa methyl chloride.
HPMC yavuyemo yogejwe, irayungurura kandi yumishwa kugirango ibone ifu yera, itemba ubusa. Imiterere ya HPMC, nka viscosity, solubilité, na gel gel, irashobora guhuzwa muguhindura urwego rwo gusimbuza (DS) ya hydroxypropyl na methyl matsinda.
Ikoreshwa rya HPMC
HPMC ifite porogaramu zitandukanye mubikorwa bitandukanye. Porogaramu zimwe zigaragara zaganiriweho hepfo:
Inganda zimiti
HPMC ikoreshwa cyane mubikorwa bya farumasi nkibibyimbye, binder na firime byahoze. Ikoreshwa muburyo bwa tablet kugirango igenzure irekurwa ryibiyobyabwenge. HPMC ikora nka binder muguhuza ifu ivanze muburyo bukomeye. Itezimbere kandi ibishishwa hamwe na bioavailable yimiti idashonga neza mugukora ibintu bihamye kandi bihuje.
inganda z'ibiribwa
HPMC ikoreshwa mu nganda y'ibiribwa nka emulisiferi, ikabyimbye kandi ikomeza. Bikunze gukoreshwa mubikoni, ice cream nibikomoka ku mata. HPMC itezimbere ibiryo no guhuza ibiryo mukurinda gutandukanya ibiyigize no kugabanya synereze. Yongera kandi uburyohe hamwe nubuzima bwibiryo.
Inganda zo kwisiga
HPMC ikoreshwa mubikorwa byo kwisiga nkibyimbye na emulifier. Ikoreshwa mubicuruzwa byita kumubiri no kumisatsi nkamavuta yo kwisiga, amavuta, shampo na kondereti. HPMC itezimbere imiterere nuburyo buhoraho bwibicuruzwa kandi itanga inyungu nziza.
inganda zubaka
HPMC ikoreshwa mu nganda zubaka nk'inyongera ya sima, minisiteri na gypsumu. Itezimbere imikorere nogukomeza amazi yibikoresho, bityo bikongerera imbaraga nigihe kirekire. HPMC igabanya kandi ibyago byo guturika no kugabanuka mugihe cyumye.
mu gusoza
Mu gusoza, HPMC ni polymer itandukanye kandi ihindagurika hamwe nibikorwa mubikorwa bitandukanye. Itegurwa no kuvura alkali ya selile, reaction hamwe na oxyde ya propylene, hamwe na quaternisation hamwe na methyl chloride. Imiterere ya HPMC irashobora guhuzwa muguhindura urwego rwo gusimburwa. HPMC igira uruhare runini mu nganda zimiti, ibiryo, amavuta yo kwisiga nubwubatsi mu kunoza imiterere, guhuza no gukora ibicuruzwa bitandukanye. Kuba idafite uburozi hamwe na biocompatibilité ituma iba ingirakamaro kandi ifite agaciro muri izi nganda.
Igihe cyo kohereza: Kanama-03-2023