Nigute Hydroxypropyl Methylcellulose (HPMC) ikorwa?

Hydroxypropyl methylcellulose (HPMC) ni polymer ya kimwe cya kabiri cyogukoresha amazi ya elegitoronike ikunze gukoreshwa mubikorwa bya farumasi, ubwubatsi ninganda zibiribwa, nibindi. Bikomoka kuri selile, polymer karemano iboneka murukuta rwibimera. Ibikurikira nubusobanuro rusange bwibikorwa bya HPMC:

Inkomoko ya selile:

Ibikoresho nyamukuru bibyara umusaruro HPMC ni selile, ishobora gukomoka ku biti cyangwa ibiti by'ipamba. Inkwi zinkwi nisoko isanzwe kuko ni myinshi kandi ihendutse.

Kuvura alkali:

Cellulose ivurwa na alkali (ubusanzwe hydroxide ya sodium) kugirango ikureho umwanda na hemicellulose. Iyi nzira, yitwa mercerisation, itanga selile nziza.

Etherification:

Cellulose isukuye noneho ikorerwa etherification, imiti yimiti itangiza amatsinda ya ether mumugongo wa selile. Kuri HPMC, hydroxypropyl na methyl byombi byinjizwa kuri molekile ya selile.

Hydroxypropylation:

Okiside ya propylene ikoreshwa mugutangiza amatsinda ya hydroxypropyl muri selile. Iyi ntambwe ikubiyemo reaction ya oxyde ya propylene na selile imbere ya catalizator.

Methylation:

Amatsinda ya methyl yinjizwa muri hydroxypropylated selile ikoresheje methyl chloride cyangwa sulfate ya dimethyl. Iyi ntambwe yitwa methylation.

Kutabogama no gukaraba:

Nyuma ya etherification reaction, ibicuruzwa bitagira aho bibogamiye kugirango bikureho ishingiro risigaye. HPMC yavuyemo noneho irakaraba kugirango ikuremo ibicuruzwa nibimiti idakozwe.

kumisha:

Intambwe yanyuma ikubiyemo kumisha HPMC kugirango ikureho amazi arenze kandi ibone ibicuruzwa wifuza mubifu cyangwa muburyo bwa granular.

Ni ngombwa kumenya ko amakuru arambuye yuburyo bwo gukora ashobora gutandukana hagati yababikora, kandi barashobora gukoresha imiterere itandukanye, catalizator, na reagent kugirango bagere kubikorwa bifuza HPMC. Byongeye kandi, ingamba zo kugenzura ubuziranenge zishyirwa mubikorwa mubikorwa byose kugirango habeho guhuza no kweza ibicuruzwa byanyuma.