Ibintu bigira ingaruka ku bwiza bwa hydroxypropyl methylcellulose

Hydroxyl methyl selulose (HPMC) ni polymer ikoreshwa cyane mubiyobyabwenge, kwisiga, ibiryo nizindi nganda. Ibiranga umwihariko wacyo, nkubukonje bwinshi, amazi meza -gushonga hamwe nubushobozi bwo gukora membrane, bigatuma iba ikintu cyingenzi muburyo butandukanye. Ubukonje nicyo kintu cyingenzi kiranga HPMC mubisabwa. Ubukonje bwa HPMC bugira ingaruka ku bintu bitandukanye, nko kwibanda, ubushyuhe, pH, n'uburemere bwa molekile. Gusobanukirwa nibintu bigira ingaruka kumyumvire ya HPMC ningirakamaro mugutezimbere. Iyi ngingo iraganira ku bintu bigira ingaruka ku bwiza bwa hydroxylopyl methyl selulose.

Wibande

Kwishyira hamwe kwa HPMC ni kimwe mu bintu by'ingenzi bigira ingaruka ku bwiza bwayo. Ubukonje bwibisubizo bya HPMC bwiyongera hamwe no kwiyongera kwibitekerezo. Mugihe cyo hasi cyane, urunigi rwa HPMC rwatatanye cyane mumashanyarazi, bityo ubukonje buri hasi. Nyamara, iyo yibanze cyane, urunigi rwa polymer rukunda gukorana, bikavamo ubwiza bwinshi. Kubwibyo, ubwiza bwa HPMC buragereranywa nubunini bwa polymer. Kwibanda kandi bigira ingaruka kumyitwarire ya HPMC. HPMC irashobora kwibanda cyane kuri gel, ifite akamaro kanini mubikorwa bya farumasi nibiribwa.

ubushyuhe

Ubushyuhe ni ikindi kintu cyingenzi kigira ingaruka ku bwonko bwa hydroxylopenyl selile. Ubukonje bwa HPMC buragabanuka hamwe n'ubushyuhe bwiyongera. Urunigi rwa HPMC ruhinduka byinshi mubushyuhe bwo hejuru, bikavamo ubukonje buke. Ugereranije nibisubizo bihanitse, ingaruka zubushyuhe kumitsi ya HPMC iragaragara cyane mubisubizo bike. Ubwiyongere bwubushyuhe buzagira ingaruka no gukomera kwa HPMC. Ku bushyuhe bwo hejuru, imbaraga za HPMC ziragabanuka, bigatuma igabanuka ryijimye ryatewe no kugabanuka kwurunigi.

pH

PH yumuti wa HPMC nikindi kintu cyingenzi kigira ingaruka nziza. HPMC ni polymer acide nkeya, hamwe na PKA ya 3.5. Kubwibyo, viscosity yumuti wa HPMC yunvikana kuri pH yumuti. Munsi ya pH irenze PKA, itsinda ryumunyu wa karubasi ya acide ya polymer yakoreshwaga na protonisation, bigatuma solubile ya HPMC yiyongera, kandi ubukonje bwaragabanutse kubera kugabanuka kwa hydrogène ya molekile interconsiscence. Munsi ya pH munsi ya PKA, itsinda rya acide karubike ya polymer yari misa, itera imbaraga nke hamwe nubukonje bwinshi buterwa no kwiyongera kwa hydrogen. Kubwibyo, pH nziza nziza yumuti wa HPMC biterwa nibiteganijwe.

Uburemere bwa molekile

Uburemere bwa HPMC ni ikindi kintu cyingenzi kigira ingaruka nziza. HPMC ni polymer polymer. Mugihe uburemere bwa molekuline ya polymer bwiyongera, ubwiza bwumuti wa HPMC buziyongera. Ibi biterwa nuko uburemere buke bwa molekile urunigi rwa HPMC rufunze cyane, bigatuma ubwiyongere bwiyongera. Uburemere bwa molekuline ya polymer nayo igira ingaruka kuri HPMC. HPMC polymer irashobora gukora geles kuruta polimeri yuburemere buke.

Umunyu

Kongera umunyu mubisubizo bya HPMC birashobora kugira ingaruka zikomeye kubwiza bwayo. Umunyu ugira ingaruka kuri ion imbaraga zumuti wa HPMC, uhindura imikoranire ya polymers. Mubisanzwe, kongeramo umunyu mubisubizo bya HPMC bizatera ubukonje kugabanuka. Ni ukubera ko imbaraga za ion zumuti zigabanuka hagati yingufu za molekuline hagati yumunyururu wa polymer HPMC, bityo bikagabanya kugabanuka kwurunigi, bityo ubwiza bukagabanuka. Ingaruka z'umunyu ku bwiza bw'umuti wa HPMC biterwa n'ubwoko n'ubwinshi bw'umunyu.

mu gusoza

Ubukonje bwa hydroxydal cibolin nikintu cyingenzi kigira ingaruka mubikorwa byacyo mubikorwa bitandukanye. Ibintu bigira ingaruka kumyuka ya HPMC harimo kwibanda, ubushyuhe, pH, uburemere bwa molekile n'umunyu. Gusobanukirwa nibi bintu kuri viscosity ya HPMC ni ngombwa kugirango uhindure imikoreshereze yayo muri porogaramu zitandukanye. Igisubizo cya HPMC kirashobora guhindurwa muburyo bukwiye kugirango ugere kubwiza busabwa bwihariye.