Itandukaniro hagati ya CMC na HPMC

Carboxymethyl selulose (CMC) na hydroxypropyl methylcellulose (HPMC) ni ubwoko bubiri bukomoka kuri selile bukoreshwa cyane mu nganda z’ibiribwa, imiti, n’ubuvuzi bwihariye. Mugihe byombi bikoreshwa nkibibyimbye, stabilisateur, na emulisiferi, hari itandukaniro ryingenzi hagati ya CMC na HPMC ituma bibera mubikorwa bitandukanye. Muri iki kiganiro, tuzaganira ku itandukaniro riri hagati ya CMC na HPMC ukurikije imiterere y’imiti, imiterere, imikoreshereze, n’umutekano.

1. Imiterere yimiti

CMC ni polymer yamazi ashonga ikomoka kuri selile, ni polymer karemano iboneka murukuta rwibimera. Imiterere yimiti ya CMC irangwa nitsinda rya carboxymethyl (-CH2-COOH) ifatanye numugongo wa selile. Urwego rwo gusimbuza (DS) rwa CMC bivuga umubare wamatsinda ya carboxymethyl aboneka kuri anhydroglucose unit (AGU) yumugongo wa selile. DS ya CMC irashobora kuva kuri 0.2 kugeza kuri 1.5, hamwe nibiciro bya DS byerekana urwego rwo hejuru rwo gusimburwa.

HPMC kandi ni polymer yamashanyarazi ikomoka kuri selile. Ariko, bitandukanye na CMC, HPMC yahinduwe hamwe na hydroxypropyl hamwe na methyl. Amatsinda ya hydroxypropyl (-OCH2CHOHCH3) yometse kumatsinda ya hydroxyl kumugongo wa selile, mugihe amatsinda ya methyl (-CH3) yometse kumatsinda ya hydroxypropyl. Urwego rwo gusimbuza HPMC bivuga umubare wa hydroxypropyl na methyl matsinda aboneka kuri AGU yumugongo wa selile. DS ya HPMC irashobora kuva kuri 0.1 kugeza 3.0, hamwe nibiciro bya DS byerekana urwego rwo hejuru rwo gusimburwa.

2. Ibyiza

CMC na HPMC bifite imitungo itandukanye ituma ibera porogaramu zitandukanye. Bimwe mubintu byingenzi bya CMC na HPMC byerekanwe hano hepfo:

a. Gukemura: CMC irashonga cyane mumazi kandi ikora ibisubizo bisobanutse neza. HPMC nayo irashonga cyane mumazi, ariko ibisubizo birashobora kuba bibi bitewe nurwego rwo gusimburwa.

b. Rheologiya: CMC ni ibikoresho byitwa pseudoplastique, bivuze ko byerekana imyitwarire yoroheje. Ibi bivuze ko ubwiza bwa CMC bugabanuka uko igipimo cyogosha cyiyongera. Ku rundi ruhande, HPMC, ni ibikoresho bya Newtonian, bivuze ko ububobere bwayo buguma buhoraho hatitawe ku gipimo cyogosha.

c. Imiterere yo gukora firime: CMC ifite imiterere myiza yo gukora firime, ituma ikoreshwa neza muri coatings na firime. HPMC ifite kandi imiterere yo gukora firime, ariko firime zirashobora kuba zoroshye kandi zikunda gucika.

d. Igihagararo: CMC ihagaze neza murwego runini rwa pH nubushyuhe. HPMC nayo irahagaze hejuru ya pH yagutse, ariko ituze ryayo irashobora guterwa nubushyuhe bwo hejuru.

3. Gukoresha

CMC na HPMC bikoreshwa muburyo butandukanye mubisabwa mubiribwa, imiti, ninganda zita kubantu. Bimwe mubyingenzi byingenzi bikoreshwa na CMC na HPMC byerekanwe hano hepfo:

a. Inganda zibiribwa: CMC isanzwe ikoreshwa nkibibyimbye, stabilisateur, na emulifisiyeri mubicuruzwa byibiribwa nka ice cream, kwambara salade, nibicuruzwa bitetse. HPMC ikoreshwa kandi mubyimbye kandi bigahindura ibicuruzwa byibiribwa, ariko ikoreshwa cyane nkibikoresho byo gutwikira ibicuruzwa bikarishye nka bombo ya gummy na shokora.

b. Inganda zikoreshwa mu bya farumasi: CMC ikoreshwa nkibikoresho bihuza, bidahwitse, hamwe na tableti yububiko bwa farumasi. HPMC ikoreshwa kandi nka binder, disintegrant, na tablet coating agent mugukora imiti.