CMC Yagenewe gukoresha imiti

CMC (carboxymethylcellulose) ni amazi ashonga, polymer ya anionic ikoreshwa cyane nkibicuruzwa munganda zimiti. Bikomoka kuri selile, bisanzwe bibaho polysaccharide, wongeyeho amatsinda ya carboxymethyl mumiterere yayo. CMC izwiho gukora filime nziza cyane no kubyimba, bigatuma iba ibintu byinshi kandi byingenzi mubintu byinshi bya farumasi.

Muri farumasi, CMC ikoreshwa cyane mubyimbye, stabilisateur, na lubricant. Nkibyimbye, CMC ikoreshwa muburyo butandukanye, nka cream, amavuta yo kwisiga, hamwe na geles, kugirango itange ubwiza no kunoza imiterere yabyo. Ibi bifasha kuzamura ituze no guhuzagurika kwibicuruzwa, byoroshe kubishyira mu bikorwa kandi binezeza abarwayi gukoresha. CMC ikoreshwa kandi nka stabilisateur muguhagarika no kumera, ifasha mukurinda ibice gutuza no kwemeza ko ibicuruzwa bikomeza kuba kimwe. Byongeye kandi, CMC ikoreshwa nk'amavuta yo kwisiga muri tablet na capsule, ifasha kunoza imigendekere yabo no koroshya kumira.

Bumwe mu buryo bukoreshwa cyane bwo kuvura bwa CMC ni muburyo bw'amaso. CMC ikoreshwa mubitonyanga byamaso n'amarira yubukorikori kugirango itange amavuta kandi igabanye ibimenyetso byamaso yumye. Ijisho ryumye nikintu gisanzwe kibaho mugihe amaso adatanga amarira ahagije cyangwa mugihe amarira ashize vuba. Ibi birashobora kugutera kurakara, gutukura, no kutamererwa neza. CMC ni uburyo bwiza bwo kuvura amaso yumye kuko bifasha kunoza igihe no kugumana igihe cya firime yamosozi hejuru ya ocular, bityo bikagabanya gukama no kurakara.

Usibye kuba ikoreshwa mu kuvura amaso, CMC ikoreshwa no mu miti imwe n'imwe yo mu kanwa kugira ngo igabanuke kandi igabanuke. CMC irashobora gukoreshwa nkibidahwitse mubinini, ibafasha kumeneka vuba mumitsi yigifu no kunoza bioavailable yibintu bikora. CMC irashobora kandi gukoreshwa nka binder muri tablet na capsule, ifasha guhuriza hamwe ibintu bikora hamwe no kunoza compressible.

CMC ni ibintu byemewe cyane mu nganda zimiti kandi bigengwa ninzego zinyuranye zishinzwe kugenzura ibiyobyabwenge ku isi. Muri Amerika, FDA (Ubuyobozi bushinzwe ibiryo n'ibiyobyabwenge) igenga CMC nk'inyongeramusaruro kandi nk'ibikoresho bidakora mu biyobyabwenge. FDA yashyizeho ibisobanuro byerekana ubuziranenge nubuziranenge bwa CMC ikoreshwa mu miti y’imiti kandi yashyizeho urwego ntarengwa rw’imyanda n’ibisigara bisigaye.

Mu Muryango w’ubumwe bw’ibihugu by’Uburayi, CMC igengwa na Pharmacopoeia y’Uburayi (Ph. Eur.) Kandi ishyirwa ku rutonde rw’ibicuruzwa bishobora gukoreshwa mu bicuruzwa bivura imiti. Ph. yashyizeho kandi ibisobanuro ku bwiza n’ubuziranenge bwa CMC ikoreshwa mu miti y’imiti, harimo imipaka y’imyanda, ibyuma biremereye, hamwe n’ibisigara bisigaye.

Muri rusange, CMC igira uruhare runini mubikorwa byinshi bya farumasi kandi ikoreshwa muburyo butandukanye bwo kuvura. Ubwiza bwayo buhebuje, butajegajega, kandi busiga amavuta butuma ibintu byinshi bihinduka bishobora gukoreshwa muburyo butandukanye. Nkibikoresho byagenwe, ibigo bikorerwamo ibya farumasi birashobora kwishingikiriza kuri CMC kugirango ibe ifite umutekano, ikora neza, kandi yujuje ubuziranenge mubikorwa byayo.