Imiterere yimiti hamwe na synthesis ya hydroxypropyl methylcellulose (HMPC)

Hydroxypropyl methylcellulose (HPMC) ni polymer yubukorikori ikomoka kuri selile kandi ikunze gukoreshwa nkibyimbye, emulisiferi, na stabilisateur mubikorwa bitandukanye nkibiryo, imiti, na cosmetike. HMPC ni hydroxypropylated ikomoka kuri methylcellulose (MC), amazi ya elegitoronike ya nonionic selulose ether agizwe na mikorobe na hydroxypropylated selile. HMPC ikoreshwa cyane nkibintu byangiza imiti bitewe nuburozi bwayo, ibinyabuzima, hamwe na biodegradabilite.

Imiti ya HMPC:

Imiterere yimiti ya HMPC yitirirwa kuba hydroxyl na ether matsinda mumiterere yayo. Amatsinda ya hydroxyl ya selile arashobora gukoreshwa binyuze mumiti itandukanye ya chimique, nka etherification, esterification, na okiside, kugirango yinjize amatsinda atandukanye mumikorere ya polymer. HMPC ikubiyemo imitekerereze yombi (-OCH3) na hydroxypropyl (-OCH2CHOHCH3), ishobora kugenzurwa kugirango itange ibintu bitandukanye nko kwikemurira ibibazo, kwiyegeranya no kwizana.

HMPC irashobora gushonga cyane mumazi, ikora ibisubizo bisobanutse neza, bigaragara neza. Ubwiza bwibisubizo bya HMPC burashobora guhinduka muguhindura urwego rwo gusimbuza (DS) mumatsinda ya hydroxypropyl, igena umubare wibibanza bya hydroxyl byahinduwe kuri glucose. Iyo DS iri hejuru, niko igabanuka kandi niko hejuru ya viscosity yumuti wa HMPC. Uyu mutungo urashobora gukoreshwa mugucunga irekurwa ryibintu bikora bivuye muri farumasi.

HMPC irerekana kandi imyitwarire ya pseudoplastique, bivuze ko ububobere bugabanuka hamwe no kongera igipimo cyogosha. Iyi mitungo ituma ikwirakwira nkibibyimbye byamazi akeneye kwihanganira imbaraga zogosha mugihe cyo gutunganya cyangwa gusaba.

HMPC ihagaze neza kugeza ubushyuhe runaka, hejuru yayo itangira kwangirika. Ubushyuhe bwo kwangirika bwa HMPC biterwa na DS hamwe nubunini bwa polymer mubisubizo. Ubushyuhe bwo kwangirika bwa HMPC bivugwa ko ari 190-330 ° C.

Synthesis ya HMPC:

HMPC ikomatanyirizwa hamwe na etherification reaction ya selile hamwe na oxyde ya propylene na methylethylene oxyde imbere ya catalizike ya alkaline. Igisubizo kigenda mubyiciro bibiri: icya mbere, amatsinda ya methyl ya selile asimburwa na okiside ya propylene, hanyuma amatsinda ya hydroxyl agasimburwa na okiside ya methyl etylene. DS ya HMPC irashobora kugenzurwa muguhindura umubyimba wa oxyde ya propylene na selile mugihe cya synthesis.

Ubusanzwe reaction ikorwa mumazi yo mumazi hejuru yubushyuhe n'umuvuduko. Umusemburo wibanze mubisanzwe ni sodium cyangwa potasiyumu hydroxide, ibyo bikaba byongera imbaraga mumatsinda ya hydroxyl ya selile yerekeje kumpeta ya epoxide ya okiside ya propylene na methylethylene. Igicuruzwa cya reaction noneho kidafite aho kibogamiye, kwozwa no gukama kugirango ubone ibicuruzwa bya nyuma bya HMPC.

HMPC irashobora kandi guhuzwa no gukora selile hamwe na oxyde ya propylene na epichlorohydrin imbere ya catisale ya aside. Ubu buryo, buzwi nka epichlorohydrin inzira, bukoreshwa mu gukora ibikomoka kuri selile cationic selulose, byishyurwa neza kubera ko hari amatsinda ya amonium ya kane.

mu gusoza:

HMPC ni polymer ikora cyane ifite imiti myiza yimiti ikwiranye ninganda zitandukanye mubikorwa bitandukanye. Synthesis ya HMPC ikubiyemo etherification ya selile hamwe na oxyde ya propylene na methylethylene oxyde imbere ya catalizike ya alkaline cyangwa catisale acide. Imiterere ya HMPC irashobora guhuzwa no kugenzura DS hamwe nubunini bwa polymer. Umutekano hamwe na biocompatibilité ya HMPC bituma uhitamo neza imiti yimiti.