Ubwa mbere, icyongereza ahinnye y'ibikoresho bifasha
MC: Methyl selile
EC: Ethyl selile
HPC: hydroxypropyl selile
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl selulose phthalates
HPMCAS: hydroxypropyl methyl selulose acetate succinate
Cmc-na: Sodium carboxymethyl selulose
MCC: Microcrystalline selile
PVP: Povidone
PEG: polyethylene glycol
PVA: Inzoga ya Polyvinyl
Cms-na: Sodium carboxymethyl ibinyamisogwe
PVPP: Povidone ihuza
CCNa: guhuza sodium carboxymethyl selulose
Babiri, ikoreshwa ryibikoresho bimwe bifasha
1. Lactose: tablet: yuzuza, cyane cyane ifu yuzuye ibinini byuzuza; Gutera inshinge: kurinda lyofilize
2. Microcrystalline selulose: tablet: ifu ikanda byuzuza ibinini byuzuye; “Amashanyarazi yumye”; Ibinini birimo microcrystalline selile 20% ikora nka disintegrator
3. Methyl selulose: tablet: ifata; Umukozi uhagarikwa: infashanyo yo guhagarika; Buhoro buhoro (kugenzurwa) gusohora: hydrophilic gel skeleton ibikoresho (intege)
4 sodium carboxymethyl selulose: ibinini: bifata; Umukozi uhagarikwa: infashanyo yo guhagarika; Buhoro buhoro (bugenzurwa) gusohora: hydrophilic gel skeleton ibikoresho
5. Ethyl selulose: ibinini: bifata (bidashonga mumazi); Gutegura buhoro buhoro (kugenzurwa): ibikoresho bya skeleton cyangwa ibikoresho bigenzurwa na membrane; Ikwirakwizwa rikomeye: ibikoresho bitwara ibintu bidashonga
6 hydroxypropyl selulose: tablet: ibifatika, ibikoresho byo gutwika firime; Umukozi uhagarikwa: infashanyo yo guhagarika; Gutegura buhoro buhoro (kugenzurwa): hydrophilic gel skeleton ibikoresho, microporous membrane yatwikiriye urupapuro pore-itera;
7. Hydroxypropyl methyl selulose (hydroxypropyl methyl selulose): ibinini: ibifatika, ibikoresho bya firime; Umukozi uhagarikwa: infashanyo yo guhagarika; Gutegura buhoro buhoro kugenzura: hydrophilic gel skeleton ibikoresho, microporous membrane yatwikiriye urupapuro pore-itera;
8. Cellulose acetate phthalates: ibikoresho byinjira
9. Hydroxypropyl selulose phthalates: ibikoresho byinjira
10. Hydroxypropyl selulose acetate ihindagurika: ibikoresho byinjira
11. Polyvinyl phthalate (PVAP): ibikoresho byinjira
12. Styrene Maleic aside copolymer (StyMA): ibikoresho byo mu nda
13. Resin ya Acrylic (ubwoko bwa enteric I, II, III), Eudragit L, Eudragit S (rimwe na rimwe Eudragit L100 cyangwa Eudragit S 100): ibikoresho byinjira
14.Eudragit RL, Eudragit RS :: Ibikoresho bitwara ibintu bitangirika
15.Eudragit E (ihwanye na acrylic IV): ibikoresho bya gastric soluble polymer
16.
17. Polyvinylpyrrolidone (povidone PVP): ibinini: ibifata; Tablet: gastric soluble firime coating material; Pellets: pellet nifedipine (dispersion ikomeye); Umukozi uhagarikwa: infashanyo yo guhagarika;
Gutatanya gukomeye: ibikoresho bitwara amazi-bishonga; Buhoro buhoro (bugenzurwa) gusohora: hydrophilic colloid skeleton ibikoresho; Buhoro buhoro (bugenzurwa) imyiteguro yo gusohora: umukozi utera pore muri microporome membrane yatwikiriye ibinini
18. Inzoga ya Polyvinyl: umukozi wa firime: ibikoresho bikora firime, imfashanyo yo guhagarika
19. Sodium carboxymethyl krahisi: tablet: umukozi wo gusenya
20. Guhuza povidone: Tablet: disintegrant
21. Guhuza sodium carboxymethyl selulose: tablet: umukozi wo gusenya
22. Hydroxypropyl selulose isimbuwe nkeya: Tablet: disintegrant
23. Acide polylactique: ibikoresho bya polymer biodegradable, ikoreshwa mugutegura microsperes, nanoparticles, nibindi
24. Glycerol (sorbitol propylene glycol ikora cyane kuri glycerol)
Imyiteguro y'amazi: solvent, inshinge, infashanyo yo guhagarika, moisturizer
Plastiseri muri capsule nibikoresho byo gutwikira
Amavuta, sisitemu yo gutanga transdermal: abamamaza kwinjira
Ongera ububobere bwimiti ya hydrophobique, igenzura ryumuvuduko wa osmotic mumavuta yimitsi yinjira
Glycerin gelatin (kumavuta, amavuta, ibintu bikomeye)
25. Glycerin gelatin
Ibinini byo guta: matrike y'amazi
Suppository: matrike y'amazi
Amavuta: Matrike y'amazi
26. Sodium dodecyl sulfate (anionic surfactant)
Emulisiyo, amavuta: emulisiferi
Umukozi wohanagura imyiteguro ihamye / amavuta yo kwisiga
solubilizer
27. Polyethylene glycol (PEG)
Ibinini: Amavuta meza-amavuta (PEG 4000, 6000)
Tablet: Plastiseri mugutondekanya firime
Capsule: Capsule yoroshye idafite amavuta meza (PEG 400)
Ibinini bitonyanga: Matrike ikemura amazi (PEG 4000, 6000,9300)
Suppository: matrix ya suppository
Aerosol: Umuti utinze (PEG 400, 600)
Gutera inshinge: Umuti (PEG 400, 600)
Gutegura amazi: Solvent (PEG 400, 600)
Gutatanya gukomeye: umutwara
Buhoro buhoro (bugenzurwa) imyiteguro yo gusohora: umukozi utera pore muri microporome membrane yatwikiriye ibinini
Gutegura kwinjirira muburyo butandukanye: kongera imbaraga za transdermal
28.
Ikwirakwiza rikomeye, matrike ya suppository, emulifier yo gutera inshinge
Inshamake ya antiseptic na bacteriostatic agent
Hydroxyl benzene ester (neper zahabu), aside benzoic, sodium benzoate, aside sorbic, benzalkonium bromide (gusukurwa gushya), chloride ya benzalkonium (jie er gupfa), acetate ya chlorhexidine, inzoga ya benzyl (ububabare bwaho) icyarimwe, ihuza imipaka hamwe na alcool ya butyl (ububabare bwaho) icyarimwe, nitrobenzene, mercure, thimerosal, net defection, ortho-fenyl phenol, phenoxyethanol, amavuta ya eucalyptus, amavuta ya cinnamoni, amavuta ya peppermint, nibindi.
Icya kane, uburyo bwo kuboneza urubyaro
1 / Gutera glucose, emulsiyo yamavuta yo gutera inshinge, dextran, sodium chloride infusion, icyuma cya reberi nibindi byuma bishyushye;
2 / Gutera Vitamine C, inshinge za hydrochloride ya procaine, inshinge ya cortisone acetate, ibitonyanga by'amaso ya chloramphenicol byatewe no kuzunguruka;
3 / Amavuta yo gutera inshinge, amavuta ya matrix, ampule ukoresheje uburyo bwumye bwumye;
4 / Asepsis icyumba cyumwuka, hejuru yimeza ikora: uburyo bwa ultraviolet sterilisation cyangwa uburyo bwa fumigasi ya gaz;
5 / Ukuboko, ibikoresho bya aseptic: uburyo bwo kuboneza imiti
6 / Gutera insuline nibindi bicuruzwa byibinyabuzima: uburyo bwo kuyungurura
V. Ingano ifitanye isano
1. Ingano ya Noyes-whitney: isobanura igipimo cyo gusesa imiti ikomeye.
2. Ubushuhe bukomeye bugereranije nubushuhe buvanze
hygroscopicity yifu ya P68)
3. Igiciro cyo gusimbuzasuppository P87)
4.Poiseuile formula: sobanura ibintu bitera akayunguruzo (inshinge P124)
5. Kubara formulaire ya isotonic igenga uburyo bwo kugabanya ingingo yo kugabanyainshinge P156)
6. Kubara agaciro ka HLB ya surfactant ivanzeamazi P178)
Tekinoroji yo gutegura
1.
2. Kwinjiza ibintu: uburyo bwuzuye bwamazi yo gukemura, uburyo bwo gusya, guhagarika uburyo bwo kumisha, uburyo bwo kumisha spray
3. Gutatanya gukomeye: uburyo bwo gushonga, uburyo bwo gushonga, uburyo bwo gushonga - uburyo bwo gushonga, umusemburo - uburyo bwo kumisha spray, uburyo bwo gusya
4.
5. Microsperes: emulisation - uburyo bwo gukiza, uburyo bwo kumisha spray, uburyo bwo kumisha amazi
6.
.
8 suppository: uburyo bushyushye bwo gushonga, uburyo bwo gukanda bukonje, uburyo bwo gukata
9. Amavuta: uburyo bwo gusya, uburyo bwo gushonga, uburyo bwa emulisation
Umukozi wa firime 10: uburyo bwo gukora firime ya homogenized slurry flow uburyo, uburyo bwo gukora firime-gushonga, uburyo bwo gukora film
Birindwi, ibikoresho bihagarariye
1. Microcapsule: gelatin - amenyo yicyarabu
2. Kwinjiza ibice: cyclodextrin
3. Gutatana gukomeye: PEG, PVP
4. Liposomes: fosifolipide-cholesterol
5. Microsperes: gelatin, albumin, PLA, nibindi
6. Suppository: amavuta ya cakao
7. Amavuta: Jelly ya peteroli, nibindi
Umukozi wa firime 8: PVA
Umunani, igihe gito
1. Ampule sterisile igomba gusigara amasaha atarenze 24;
2. Kubika amazi yo gutera inshinge ntibishobora kurenza amasaha 12;
3. Kurandura inshinge rusange bizarangira mumasaha 12 nyuma yo kubumba;
4. Gutegura no gukemura ibisubizo bizarangira mugihe cyamasaha 4 nyuma yo kuboneza urubyaro
9. Ibikoresho byo kugenzura ubuziranenge bijyanye no gutegura imiti
1. Ibinini: ibiranga isura; Gutandukanya ibiro; Ubukomezi n'ubugome; Impamyabumenyi; Iseswa cyangwa kurekurwa; Guhuza ibirimo
2. Gutatanya umukozi: uburinganire; Ubushuhe. Gutandukanya ingano; Isuzuma ry'ubuzima; Kugenzura ubwinshi
3. Granule: isura; Ingano y'ibice; Kugabanya ibiro byumye; Gushonga; Itandukaniro ry'umutwaro
4. Capsule: isura; Ubushuhe. Gutandukanya ingano; Gusenyuka no guseswa.
5. Kureka ibinini: itandukaniro ryibiro; Kugenzura igihe ntarengwa cyo kugenzura, nibindi
6. Ibitekerezo: isura; Itandukaniro mubiro; Gushonga igihe ntarengwa; Urwego rwo gushonga; Muri test yo gusesa vitro no mubizamini bya vivo
7. Pompa: ingano yingingo; Umutwaro; Imipaka ya mikorobe; Ibiyobyabwenge nyamukuru; Imiterere yumubiri; Stimulus; Guhagarara; Kurekura, kwinjira no kwinjiza ibiyobyabwenge mumavuta.
8. Ibice bya transdermal: itandukaniro ryibiro; Itandukaniro ry'akarere; Guhuza ibirimo; Kurekura impamyabumenyi, nibindi
10. Ibisobanuro bitandukanye
1. Micron 1-5000
2. Pellet: bivuga urwego rugizwe na diameter iri munsi ya 2,5mm igizwe nibiyobyabwenge nibisohoka.
3. Microsperie: microscopique yo mu bwoko bwa skeleton igizwe na skeleton igizwe no gushonga cyangwa gukwirakwiza imiti murwego rwibikoresho bya polymer, hamwe nubunini buke buri hagati ya 1 na 250 mm.
4. Nanoparticles: ibice bikomeye bya colloidal bigizwe nibintu bya polymeriki, hamwe nubunini buke buri hagati ya 10 ~ 1000nm.
5. Kureka ibinini bivura: bivuga imiti ikomeye cyangwa isukuye nibintu bikwiye (muri rusange bizwi nka matrix) kuvanga gushonga kuvanga, guta muri kondensate mbi, kugabanuka no gukora no gutegura pellet nto.
Igihe cyo kohereza: Nzeri-09-2022