Capsule Grade HPMC yo gusaba Farma

Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane munganda zimiti kubera imiterere yihariye nka solubilité nyinshi, biocompatibilité, hamwe nuburozi. Urwego rwa capsule HPMC, ruzwi kandi nka hypromellose, rwashizweho kugirango rukoreshwe mu bikoresho bya farumasi ya capsule. Muri iyi ngingo, tuzaganira ku miterere, gukora, no gushyira mu bikorwa urwego rwa capsule HPMC.

Ibyiza bya Capsule Grade HPMC

Urwego rwa capsule HPMC nigice cya sintetike, inert, na polymer-soluble polymer ikomoka kuri selile. Ni ifu yera-yera-ifu idafite impumuro nziza, uburyohe, kandi itemba ubusa. Ibintu nyamukuru bya capsule urwego HPMC ni:

Ububasha bukabije: Capsule urwego HPMC ishonga byoroshye mumazi kandi ikora ibisubizo bisobanutse. Ifite ubushyuhe buke bwa gelation, bivuze ko ishobora gukora geles mubushyuhe buke.

Kutagira uburozi: Capsule yo mu rwego rwa HPMC ni polymer idafite uburozi ifite umutekano mukurya abantu. Yemejwe kandi ninzego zinyuranye zishinzwe kugenzura nka FDA yo muri Amerika, Pharmacopoeia yu Burayi, na Pharmacopoeia y’Ubuyapani.

Biocompatibilité: Urwego rwa capsule HPMC irahuza na sisitemu y'ibinyabuzima kandi ntabwo itera ingaruka mbi kubuzima bwabantu.

pH itajegajega: Capsule urwego HPMC irahagaze murwego runini rwagaciro ka pH, bigatuma ikwiriye gukoreshwa muri acide, itabogamye, nibidukikije.

Imiterere yo gukora firime: Urwego rwa capsule HPMC irashobora gukora firime ikomeye kandi yoroheje irwanya gucika, gukuramo, no kumeneka.

Kugenzura-kurekura imitungo: Urwego rwa capsule HPMC irashobora gukoreshwa mugucunga irekurwa ryibiyobyabwenge biva muri capsule shell, bigatuma bigira akamaro mugutezimbere-kurekura.

Gukora Capsule Grade HPMC

Urwego rwa capsule HPMC ikorwa muguhindura imiti ya selile isanzwe hamwe na okiside ya propylene na methyl chloride. Urwego rwo gusimbuza (DS) rwa HPMC rushingiye ku kigereranyo cya oxyde ya propylene na methyl chloride ikoreshwa muri reaction. Agaciro DS yerekana umubare wamatsinda ya hydroxyl kuri selilose yasimbujwe hydroxypropyl na methyl.

Urwego rwa capsule HPMC iraboneka mubyiciro bitandukanye, bitewe nubwiza bwayo nurwego rwo gusimbuza. Ubukonje bwa HPMC ni igipimo cy'uburemere bwacyo bwa molekuline n'urwego rwa polymerisation. Iyo hejuru ya viscosity, niko uburemere bwa molekuline nubushakashatsi bwimbitse. Urwego rwo gusimbuza rugena solubilité na gelation ya HPMC.

Porogaramu ya Capsule Grade HPMC

Urwego rwa capsule HPMC ikoreshwa cyane mubikorwa bya farumasi mugukora capsule shell. Igikonoshwa cya capsule gikoreshwa mugukingira ibiyobyabwenge kandi bigatanga uburyo bworoshye kandi bwizewe bwo kugeza imiti kubarwayi. Ibyingenzi byingenzi bya capsule urwego HPMC muruganda rwa farumasi ni:

Imboga zikomoka ku bimera: Capsule yo mu rwego rwa HPMC ni uburyo buzwi cyane bwa gelatin capsules, bukomoka ku nyamaswa. Ibiryo bikomoka ku bimera bikozwe muri HPMC birakwiriye gukoreshwa mu bihingwa bikomoka ku bimera n’ibikomoka ku bimera kandi bifite ubushuhe buke, bigatuma bihinduka kandi byoroshye kubyitwaramo.

Kugenzura-kurekura ibyateganijwe: Urwego rwa capsule HPMC irashobora gukoreshwa mugucunga irekurwa ryibiyobyabwenge biva muri capsule. Igipimo cyo kurekura ibiyobyabwenge gishobora kugenzurwa no guhindura ububobere n’urwego rwo gusimbuza HPMC. Ibi bituma capsule urwego HPMC igira akamaro mugutezimbere-kurekura bishobora gutanga imiti irambye mugihe runaka.

Capsules ya enteric-capsules: HPMC yo mu rwego rwa capsule irashobora gukoreshwa mugukora capsules zifunze enteric, zagenewe kurekura imiti mumara ahubwo igifu. Capsules yinjizwamo ingirakamaro ni ingirakamaro ku biyobyabwenge byangiza ibidukikije bya acide yo mu gifu cyangwa bigatera uburakari ku gifu.

Kuryoha-guswera: Urwego rwa capsule HPMC irashobora gukoreshwa muguhisha uburyohe bukaze bwibiyobyabwenge bifite uburyohe budashimishije. HPMC irashobora gukoreshwa mugukora uburyohe bwo guhisha uburyohe ku biyobyabwenge, bishobora kunoza kubahiriza abarwayi no kwemerwa.

Kongera imbaraga zo gukemura: HPMC yo mu rwego rwa capsule irashobora kunoza imiti yimiti idashonga mugukwirakwiza gukomeye. HPMC irashobora gukoreshwa mugutwika ibiyobyabwenge no kunoza imiterere yabyo.

Ibyingenzi: Capsule yo mu rwego rwa HPMC irashobora gukoreshwa nkibishobora gukoreshwa muburyo butandukanye bwa farumasi nka tableti, amavuta, hamwe nuguhagarika. Irashobora gukora nka binder, disintegrant, emulsifier, na stabilisateur, bitewe nuburyo bwakozwe.

Umwanzuro

Urwego rwa Capsule HPMC ni polymer zitandukanye kandi zikoreshwa cyane mubikorwa bya farumasi. Ifite imiterere yihariye nko gukomera cyane, kutagira uburozi, hamwe na biocompatibilité, bigatuma iba ibikoresho bikwiye byo gukoreshwa muri shell ya capsule. Igikorwa cyo gukora icyiciro cya capsule HPMC gikubiyemo guhindura imiti ya selile isanzwe hamwe na okiside ya propylene na methyl chloride kugirango ibone ubwiza bwifuzwa nicyiciro cyo gusimburwa. Urwego rwa capsule HPMC rusanga porogaramu zitandukanye munganda zimiti, nko mugukora capsules zikomoka ku bimera, kugenzura-kurekura, capsules yinjizwamo enterineti, uburyohe-guhisha, kongera imbaraga, kandi nkibisanzwe muburyo butandukanye.