Hamwe n’ubushakashatsi bwimbitse bwogutanga imiti nibisabwa bikarishye, hagaragara imiti mishya yimiti, muri yo hakoreshwa hydroxypropyl methylcellulose. Uru rupapuro rusubiramo porogaramu zo mu gihugu n’amahanga za hydroxypropyl methylcellulose. Uburyo bwo kubyaza umusaruro nibyiza nibibi, ikoranabuhanga ryibikoresho hamwe niterambere ryimbere mu gihugu, hamwe nuburyo bukoreshwa mubijyanye n’ibicuruzwa bivura imiti.
Amagambo shingiro: ibikoresho bya farumasi; hydroxypropyl methylcellulose; umusaruro; Porogaramu
1 Intangiriro
Ibikoresho bya farumasi bivuga ijambo rusange kubindi bikoresho byose byimiti byongewe kumyiteguro usibye imiti nyamukuru hagamijwe gukemura imiterere, kuboneka n'umutekano byimyiteguro mugikorwa cyo kubyara no gutegura imyiteguro. Ibikoresho bya farumasi nibyingenzi cyane mugutegura imiti. Hariho ubwoko bwinshi bwimiti yimiti mubikorwa byimbere mugihugu ndetse no mumahanga, ariko mumyaka yashize, ibisabwa kugirango isuku, iseswa, ituze, bioavailable muri vivo, kunoza ingaruka zo kuvura no kugabanya ingaruka mbi zibiyobyabwenge bigenda byiyongera. , gukora vuba vuba ibintu bishya hamwe nibikorwa byubushakashatsi hagamijwe kunoza imikorere yo gutegura ibiyobyabwenge nubwiza bwimikoreshereze. Umubare munini wurugero rwamakuru yerekana ko hydroxypropyl methylcellulose ishobora kuzuza ibisabwa hejuru nkibikoresho bya farumasi byujuje ubuziranenge. Ibihe bigezweho mubushakashatsi n’umusaruro w’amahanga no kubishyira mu bikorwa mu bijyanye n’imiti y’imiti.
2 Incamake yumutungo wa HPMC
HPMC ni umweru cyangwa umuhondo muto, udafite impumuro nziza, impumuro nziza, ifu idafite uburozi iboneka hamwe na etherification ya alkali selulose, okiside ya propylene na chloride ya alkyl. Byoroshye gushonga mumazi ari munsi ya 60 ° C na 70% Ethanol na acetone, isoacetone, na dichloromethane ivanze yumuti; HPMC ifite ituze rikomeye, igaragara cyane: icya mbere, igisubizo cyayo cyamazi ntigishobora kwishyurwa kandi ntigikora numunyu wibyuma cyangwa ibinyabuzima kama ionic; kabiri, irwanya kandi acide cyangwa shingiro. Ugereranije. Nibintu biranga imiterere ya HPMC ituma ubwiza bwimiti hamwe na HPMC nkibicuruzwa bihagaze neza kurusha abafite ibicuruzwa gakondo. Mu bushakashatsi bw’uburozi bwa HPMC nkibisohoka, herekanwa ko HPMC itazahinduka mu mubiri, kandi ko itagira uruhare mu mikorere y’umubiri w’umuntu. Gutanga ingufu, nta burozi n'ingaruka zibiyobyabwenge, ibikoresho bya farumasi bifite umutekano.
3 Ubushakashatsi ku musaruro w’imbere mu gihugu no mu mahanga wa HPMC
3.1 Incamake yubuhanga bwo gukora HPMC murugo no mumahanga
Mu rwego rwo guhangana neza n’ibisabwa bigenda byiyongera kandi byiyongera by’imiti itegura imiti mu gihugu ndetse no hanze yarwo, ikoranabuhanga ry’umusaruro hamwe na HPMC naryo rihora ritera imbere mu muhanda utuje kandi muremure. Igikorwa cyo gukora HPMC gishobora kugabanywa muburyo butandukanye hamwe nuburyo bukomeza. Ibyiciro by'ingenzi. Inzira ikomeza ikoreshwa mumahanga, mugihe icyiciro gikoreshwa cyane mubushinwa. Gutegura HPMC bikubiyemo intambwe zo gutegura alkali selulose, reaction ya etherification, gutunganya imiti, no kuvura ibicuruzwa byarangiye. Muri byo, hari ubwoko bubiri bwinzira zo gutunganya etherification reaction. : Uburyo bwa gaz gaz nuburyo bwo gutemba. Ugereranije, uburyo bwa gaz gazi ifite ibyiza byubushobozi bunini bwo gukora, ubushyuhe buke, igihe gito cyo kubyitwaramo, hamwe no kugenzura neza reaction, ariko igitutu cyibisubizo ni kinini, ishoramari ni rinini, kandi iyo ikibazo kibaye, biroroshye guteza impanuka zikomeye. Uburyo bwicyiciro cyamazi muri rusange bufite ibyiza byumuvuduko muke, ingaruka nke, igiciro gito cyishoramari, kugenzura ubuziranenge bworoshye, no gusimbuza byoroshye ubwoko; ariko icyarimwe, reaction isabwa nuburyo bwamazi ya feri ntishobora kuba nini cyane, nayo igabanya ubushobozi bwa reaction. Ugereranije nuburyo bwa gaze ya gaz, igihe cyo kubyitwaramo ni kirekire, ubushobozi bwo kubyaza umusaruro ni buto, ibikoresho bisabwa ni byinshi, imikorere iragoye, kandi kugenzura ibyikora no kumenya neza biri munsi yuburyo bwa gaz. Kugeza ubu, ibihugu byateye imbere nk'Uburayi na Amerika bikoresha cyane cyane icyiciro cya gaze. Hano haribisabwa byinshi mubijyanye n'ikoranabuhanga n'ishoramari. Urebye uko ibintu byifashe mu gihugu cyacu, inzira y'amazi irasanzwe. Nyamara, hari uduce twinshi mubushinwa dukomeje kuvugurura no guhanga udushya mu ikoranabuhanga, twigira ku nzego zateye imbere z’amahanga, kandi tugatangira inzira ikomeza. Cyangwa umuhanda wo kumenyekanisha uburyo bwa gaz-fasi yuburyo.
3.2 Iterambere ry'ikoranabuhanga ry'umusaruro rya HPMC yo mu gihugu
HPMC mugihugu cyanjye ifite amahirwe menshi yiterambere. Muri ayo mahirwe meza, intego ya buri mushakashatsi ni ugukomeza kunoza ikoranabuhanga ry’umusaruro wa HPMC no kugabanya itandukaniro riri hagati y’inganda zo mu gihugu cya HPMC n’ibihugu byateye imbere mu mahanga. Inzira ya HPMC Ihuriro ryose mubikorwa bya synthesis rifite akamaro kanini kubicuruzwa byanyuma, muribyo reaction ya alkalisation na etherification [6] nibyingenzi. Kubwibyo, tekinoroji ya HPMC yo murugo irashobora gukorwa uhereye kuri ibi byerekezo byombi. Guhinduka. Mbere ya byose, gutegura alkali selulose bigomba gukorwa ku bushyuhe buke. Niba hateguwe ibicuruzwa bike-viscosity, okiside zimwe zirashobora kongerwamo; niba hateguwe ibicuruzwa byinshi-viscosity, uburyo bwo kurinda gaz inert burashobora gukoreshwa. Icya kabiri, reaction ya etherification ikorwa mubushyuhe bwinshi. Shira toluene mubikoresho bya etherification hakiri kare, ohereza alkali selulose mubikoresho hamwe na pompe, hanyuma wongeremo umubare munini wa isopropanol ukurikije ibikenewe. Mugabanye igipimo gikomeye-cyamazi. Kandi ukoreshe sisitemu yo kugenzura mudasobwa, ishobora gusubiza vuba ubushyuhe, Ibipimo bitunganijwe nkumuvuduko na pH bihita bihinduka. Birumvikana ko kunoza ikoranabuhanga rya HPMC rishobora no kunozwa inzira yinzira, gukoresha ibikoresho bibisi, gutunganya imiti nibindi.
4 Gukoresha HPMC mubijyanye n'ubuvuzi
4.1 Gukoresha HPMC mugutegura ibinini bisohora-kurekura
Mu myaka yashize, hamwe n’ubushakashatsi bwimbitse bw’ubushakashatsi bwo gutanga ibiyobyabwenge, iterambere rya HPMC rifite ubukana bwinshi mu gushyira mu bikorwa imyiteguro irekura-kurekura ryashimishije abantu benshi, kandi ingaruka zo kurekura ni nziza. Mugereranije, haracyari icyuho kinini mugukoresha ibinini-bisohora matrix. Kurugero, iyo ugereranije HPMC yo murugo no mumahanga kuri nifedipine ikomeza-kurekura ibinini kandi nka matrix ya propranolol hydrochloride ikomeza-kurekura ibinini bya matrix, usanga ikoreshwa rya HPMC murugo mugutegura-kurekura bisaba kurushaho kunozwa kugirango dukomeze kunoza iterambere urwego rwimyiteguro yo murugo.
4.2 Gukoresha HPMC mubyimbye byamavuta yo kwa muganga
Bitewe no gukenera kugenzurwa cyangwa kuvurwa ibikoresho bimwe na bimwe byubuvuzi muri iki gihe, iyo byinjiye cyangwa bisohoka mu ngingo n’umuntu, ubuso bwigikoresho bugomba kugira ibintu bimwe na bimwe bisiga amavuta, kandi HPMC ifite ibintu bimwe na bimwe byo gusiga. Ugereranije n’andi mavuta yo kwisiga, HPMC irashobora gukoreshwa nkibikoresho byo gusiga imiti, bidashobora kugabanya kwambara ibikoresho gusa, ahubwo binashobora gukenera amavuta yo kwa muganga no kugabanya ibiciro.
4
Ugereranije nibindi bikoresho bisanzwe byanditseho ibinini, HPMC ifite ibyiza bigaragara mubijyanye no gukomera, gukaranga no kwinjiza amazi. HPMC yo mu byiciro bitandukanye bya viscosity irashobora gukoreshwa nkamazi apfunyika amazi kubinini n'ibinini. Irashobora kandi gukoreshwa nka firime yo gupakira sisitemu ya solvent organic. Turashobora kuvuga ko HPMC aribikoresho bikoreshwa cyane muri firime mugihugu cyanjye. Byongeye kandi, HPMC irashobora kandi gukoreshwa nkibikoresho byerekana firime muri agent ya firime, kandi firime yo kurwanya anti-okiside yamazi yo gupakira ishingiye kuri HPMC ikoreshwa cyane mukubungabunga ibiryo, cyane cyane imbuto.
4.4 Gukoresha HPMC nkibikoresho bya capsule
HPMC irashobora kandi gukoreshwa nkibikoresho byo gutegura capsule shells. Ibyiza bya capsules ya HPMC nuko batsinze ingaruka zifatika za gelatine capsules, zifitanye isano ryiza nibiyobyabwenge, zifite umutekano muke, zishobora guhindura no kugenzura imyitwarire yo kurekura ibiyobyabwenge, kuzamura ireme ryibiyobyabwenge, Ifite ibyiza byo gusohora ibiyobyabwenge bihamye inzira. Mu mikorere, capsules ya HPMC irashobora gusimbuza burundu gelatine capsules ihari, byerekana icyerekezo cyiterambere kizaza cya capsules.
4.5 Gusaba HPMC nkumukozi uhagarika
HPMC ikoreshwa nkumukozi uhagarika, kandi ingaruka zayo zo guhagarika ni nziza. Kandi ubushakashatsi bwerekana ko gukoresha ibindi bikoresho bisanzwe bya polymer nkumukozi uhagarika gutegura ihagarikwa ryumye ugereranije na HPMC nkumukozi uhagarika gutegura ihagarikwa ryumye. Guhagarika byumye byoroshye gutegura kandi bifite umutekano uhamye, kandi ihagarikwa ryakozwe ryujuje ibisabwa byerekana ibipimo ngenderwaho bitandukanye byerekana ihagarikwa ryumye. Kubwibyo, HPMC ikoreshwa kenshi nkumukozi uhagarika imyiteguro yamaso.
4.6 Gukoresha HPMC nka blokeri, agent-kurekura buhoro na porogen
HPMC irashobora gukoreshwa nkibikorwa byo guhagarika, kurekura-kurekura no gukora pore kugirango itinde kandi igenzure irekurwa ryibiyobyabwenge. Muri iki gihe, HPMC irakoreshwa cyane mu myiteguro irekura-irekura ndetse no gutegura imiti ivura imiti gakondo yo mu Bushinwa, nko muri Tianshan Snow Lotus ikomeza-gusohora ibinini bya matrix. Gushyira mu bikorwa, ingaruka zayo zo kurekura ni nziza, kandi inzira yo kwitegura iroroshye kandi ihamye.
4.7 Gukoresha HPMC nkibibyimbye hamwe na koleide ikingira
HPMC irashobora gukoreshwa nkibyimbye [9] kugirango ikore colloide ikingira, kandi ubushakashatsi bwakozwe mubushakashatsi bwerekanye ko gukoresha HPMC nkibyimbye bishobora kongera imbaraga za karubone ikora imiti. Kurugero, isanzwe ikoreshwa mugutegura pH-yunvikana ya levofloxacin hydrochloride ophthalmic yiteguye-gukoresha-gel. HPMC ikoreshwa nkibyimbye.
4.8 Gukoresha HPMC nka bioadhesive
Ibifatika bikoreshwa muri tekinoroji ya bioadhesion ni macromolecular ivanze hamwe na bioadhesive. Mugukurikiza mucosa gastrointestinal mucosa, mucosa yo mu kanwa nibindi bice, gukomeza no gukomera kwimikoranire hagati yibiyobyabwenge na mucosa bishimangirwa kugirango bigerweho neza. . Umubare munini wibisabwa byerekana ko HPMC ishobora kuzuza ibisabwa hejuru nka bioadhesive.
Byongeye kandi, HPMC irashobora kandi gukoreshwa nkigikoresho cyo kugabanya imvura igwa kuri geles yibanze hamwe na sisitemu yo kwikorera mikorobe, kandi mu nganda za PVC, HPMC irashobora gukoreshwa nkumurinzi ukwirakwiza muri polymerisation ya VCM.
5 Umwanzuro
Mu ijambo rimwe, HPMC yakoreshejwe cyane mu gutegura imiti n’ibindi bintu bitewe n’imiterere yihariye ya fiziki n’ibinyabuzima. Nubwo bimeze bityo, HPMC iracyafite ibibazo byinshi mugutegura imiti. Ni uruhe ruhare rwihariye rwa HPMC mu gushyira mu bikorwa; uburyo bwo kumenya niba bifite ingaruka za farumasi; ni ibihe biranga bifite muburyo bwo kurekura, nibindi. Birashobora kugaragara ko mugihe HPMC ikoreshwa cyane, ibibazo byinshi bigomba gukemurwa byihutirwa. Kandi abashakashatsi benshi kandi bakora byinshi kugirango bakoreshe neza HPMC mubuvuzi, bityo bakomeze guteza imbere iterambere rya HPMC mubijyanye n’ibicuruzwa bivura imiti.
Igihe cyo kohereza: Ugushyingo-02-2022