Hydroxypropyl selile, imiti ya farumasi, igabanijwemo hydroxypropyl selulose isimbuwe nkeya (L-HPC) hamwe na hydroxypropyl selulose isimbuwe cyane (H-HPC) ukurikije ibikubiye mu itsinda ryayo rya hydroxypropoxyl. L-HPC yabyimbye mu gisubizo cya colloidal mumazi, ifite imiterere yo gufatira hamwe, gukora firime, emulisation, nibindi, kandi ikoreshwa cyane nkibintu bisenya kandi bihuza; mugihe H-HPC ibora mumazi hamwe nudukoko dutandukanye twubushyuhe bwicyumba, kandi ifite ubushyuhe bwiza. , guhuriza hamwe hamwe no gukora firime, firime yakozwe irakomeye, irabagirana, kandi iroroshye, kandi ikoreshwa cyane nkibikoresho byerekana firime nibikoresho byo gutwikira. Porogaramu yihariye ya hydroxypropyl selulose mumyiteguro ihamye ubu iratangijwe.
1. Nkibitandukanya imyiteguro ihamye nkibinini
Ubuso bwa hydroxypropyl selulose ya selile ya kristalline ntisumbana, hamwe nikirere kigaragara nk'ikirere. Iyi miterere yubuso idakabije ituma igira ubuso bunini gusa, ariko kandi iyo ihujwe mu kabaho hamwe n’ibiyobyabwenge n’ibindi bikoresho, imyenge myinshi na capillaries biba mu kibaho cya tablet, kugirango intandaro ya tablet ishobora kongera ubushuhe igipimo cyo kwinjiza no kwinjiza amazi byongera kubyimba. Gukoresha L-HPC nkibisanzwe birashobora gutuma ibinini byangirika vuba muri poro imwe, kandi bigateza imbere cyane gusenyuka, guseswa hamwe na bioavailable ya tablet. Kurugero, ikoreshwa rya L-HPC rirashobora kwihutisha isenyuka ryibinini bya parasetamol, ibinini bya aspirine, hamwe na chlorpheniramine, kandi bikazamura igipimo cyo gusesa. Gusenyuka no gusesa imiti idashonga cyane nka tabloxacin ibinini bya L-HPC nkibidahwitse byari byiza kurusha abafite PVPP ihuza, CMC-Na ihuza CMC-Na na CMS-Na nkibidahwitse. Gukoresha L-HPC nk'imbere idahwitse ya granules muri capsules ni ingirakamaro mu gusenyuka kwa granules, byongera ubuso bw’imikoranire hagati y’ibiyobyabwenge n’uburyo bwo gusesa, bigatera iseswa ry’ibiyobyabwenge, kandi bigahindura bioavailability. Ako kanya-kurekura imyiteguro ihamye ihagarariwe nubwiteganyirize bwihuse bwihuse hamwe nubwiteganyirize bukomeye bwihuse bifite gusenyuka byihuse, guhita bishonga, byihuse-byihuse, bioavailable, kugabanya uburakari bwibiyobyabwenge kuri esofagusi na gastrointestinal, kandi biroroshye gufata kandi ukurikize neza. nibindi byiza, gufata umwanya wingenzi mubijyanye na farumasi. L-HPC yabaye kimwe mubyingenzi byingenzi kugirango irekure bidatinze imyiteguro ikomeye kubera hydrophilique ikomeye, hygroscopicity, kwaguka, igihe gito cya hystereze yo kwinjiza amazi, umuvuduko ukabije wamazi, hamwe no kwiyuzuza amazi byihuse. Nibintu byiza bitandukanya kumunwa. Paracetamol ibinini bisenya umunwa byateguwe hamwe na L-HPC nkibidahwitse, kandi ibinini byacitse vuba muri 20. L-HPC ikoreshwa nka disintegrant kubinini, kandi dosiye rusange ni 2% kugeza 10%, ahanini 5%.
2. Nkumuhuza wimyiteguro nkibinini na granules
Imiterere ikaze ya L-HPC nayo ituma igira ingaruka nziza ya mozayike hamwe nibiyobyabwenge nuduce, byongera urwego rwo guhuriza hamwe, kandi bifite imikorere myiza yo kwikuramo. Nyuma yo gukanda mubinini, byerekana ubukana nuburabyo, bityo bikazamura ubwiza bwimiterere ya tablet. Cyane cyane kubinini bitoroshye gukora, birekuye cyangwa byoroshye gufungura, wongeyeho L-HPC birashobora kunoza ingaruka. Ciprofloxacin hydrochloride tablet ifite compression idahwitse, byoroshye gutandukana no gukomera, kandi biroroshye gukora nyuma yo kongeramo L-HPC, hamwe nubukomere bukwiye, isura nziza, kandi igipimo cyo gusesa cyujuje ubuziranenge bwibisabwa. Nyuma yo kongeramo L-HPC muri tablet ikwirakwizwa, isura yayo, ifiriti, uburinganire bumwe hamwe nibindi bintu biratera imbere cyane kandi biratera imbere. Nyuma ya krahisi mu nyandiko yumwimerere yasimbuwe na L-HPC, ubukana bwa tableti ya azithromycin ikwirakwizwa bwiyongereye, ifiriti iratera imbere, kandi ibibazo byo kubura imfuruka n’impande ziboze za tablet yambere byakemuwe. L-HPC ikoreshwa nka binder ya tableti, kandi dosiye rusange ni 5% kugeza 20%; mugihe H-HPC ikoreshwa nkibihuza ibinini, granules, nibindi, kandi dosiye rusange ni 1% kugeza 5% byimyiteguro.
3. Gushyira mubikorwa bya firime no gukomeza kandi kugenzura imyiteguro yo gusohora
Kugeza ubu, ibikoresho bishonga mu mazi bikunze gukoreshwa mu gutwikira firime harimo hydroxypropyl methylcellulose (HPMC), hydroxypropyl selulose, polyethylene glycol (PEG), n'ibindi. , firime yoroheje kandi yuzuye. Niba hydroxypropyl selulose ivanze nizindi miti irwanya ubushyuhe, imikorere yimyenda yayo irashobora kurushaho kunozwa.
Ukoresheje ibiyobora hamwe nubuhanga bukwiye kugirango ibiyobyabwenge bibe ibinini bya matrix, ibinini bireremba gastric, ibinini byinshi, ibinini bisize, ibinini bya pompe osmotic nibindi bisate bitinda kandi bigenzurwa, akamaro ni: kongera urwego rwo kwinjiza ibiyobyabwenge no gutuza ibiyobyabwenge mu maraso. Kwibanda, kugabanya ingaruka mbi, kugabanya umubare wimiti, kandi uharanire gukora neza hamwe nigipimo gito, kandi ugabanye ingaruka mbi. Hydroxypropyl selulose nimwe mubintu nyamukuru byitegura iyo myiteguro. Iseswa no kurekura ibinini bya sodium ya diclofenac bigenzurwa no gukoresha hydroxypropyl selulose na Ethyl selulose nkibikoresho hamwe na skeleton. Nyuma yubuyobozi bwo munwa no guhura numutobe wigifu, hejuru ya diclofenac sodium ikomeza-kurekura ibinini bizahinduka gele. Binyuze mu gusesa gele no gukwirakwiza molekile zibiyobyabwenge mu cyuho cya gel, intego yo kurekura buhoro buhoro molekile zibiyobyabwenge ziragerwaho. Hydroxypropyl selulose ikoreshwa nka matrix igenzurwa-irekura-ibinini bya tablette, mugihe ibikubiye muri blokeri ya Ethyl selulose ihoraho, ibiyirimo muri tablet bigena neza igipimo cyo kurekura ibiyobyabwenge, nibiyobyabwenge biva mubinini birimo ibintu byinshi. ya hydroxypropyl selulose Kurekura biratinda. Pellet zometseho zateguwe hakoreshejwe L-HPC nigice runaka cya HPMC nkigisubizo cyo gutwikira nk'igice cyabyimbye, kandi nkigice cyo kugenzura-kurekura kugirango gitwikire amazi ya selile ya selile. Iyo ibibyimba byabyimbye hamwe na dosiye bikosowe, mugucunga ubunini bwurwego rurekurwa, pellet zifunze zirashobora kurekurwa mubihe bitandukanye byateganijwe. Ubwoko butandukanye bwa pellet hamwe nuburemere butandukanye bwurwego rwo kugenzura kurekura bivanze kugirango Shuxiong ikomeze-kurekura capsules. Muburyo bwo gusesa, pellet zitandukanye zometseho zirashobora kurekura ibiyobyabwenge bikurikiranye mugihe gitandukanye, kuburyo ibice bifite imiterere itandukanye yumubiri nubumashini Kurekura icyarimwe bigerwaho mugihe cyo kurekura bikomeje
Igihe cyo kohereza: Mutarama-28-2023