Gukoresha HPMC mugutegura

1 nkibikoresho bya firime nibikoresho byo gukora film

Ukoresheje hypromellose (HPMC) nk'ibikoresho bisizwe na firime, ugereranije n'ibinini bisanzwe bisize nk'isukari isize isukari, ibinini bisize nta nyungu zigaragara bifite mu guhisha uburyohe bw'imiti no kugaragara, ariko ubukana bwabyo no gukaranga, kwinjiza amazi, gusenyuka, gutwikira ibiro kwiyongera nibindi bipimo byiza nibyiza. Urwego ruto-rwinshi rwibicuruzwa bikoreshwa nkibikoresho byo gukuramo amazi ya firime yifashisha ibinini n'ibinini, naho urwego rwo hejuru-rwinshi rukoreshwa nkibikoresho bifata firime kuri sisitemu yo gukemura ibibazo. Ubusanzwe kwibanda kuri 2.0% kugeza kuri 20%.

2 nka binder na disintegrant

Urwego ruto-rwinshi rwibicuruzwa rushobora gukoreshwa nkuguhuza no gutandukanya ibinini, ibinini, na granules, kandi urwego rwo hejuru rwinshi rushobora gukoreshwa gusa. Igipimo kiratandukanye nuburyo butandukanye nibisabwa. Mubisanzwe, ibipimo bya binder kubinini byumye byumye ni 5%, naho ibipimo bya binder kubinini bitose ni 2%.

3 nkumukozi uhagarika

Umukozi uhagarika ibintu ni gel ya viscous gel ifite hydrophilicity, ishobora kugabanya umuvuduko wimitsi yibice iyo ikoreshejwe muguhagarika, kandi irashobora kwomekwa hejuru yibice kugirango ibuze guhurira hamwe no kugabanuka mumupira. . Guhagarika ibikorwa bigira uruhare runini muguhagarika. HPMC ni ubwoko buhebuje bwo guhagarika ibintu, kandi igisubizo cyacyo cya colloidal cyasheshwe kirashobora kugabanya ubukana bwimiterere yimiterere-yamazi nimbaraga zubusa kubice bito bito, bityo bikazamura ituze rya sisitemu yo gukwirakwiza heterogeneous. Urwego rwohejuru-rwinshi rwibicuruzwa bikoreshwa nkuburyo bwo guhagarika ubwoko bwamazi bwateguwe nkumukozi uhagarika. Ifite ingaruka nziza yo guhagarika, iroroshye gusubiramo, ntabwo ifatanye nurukuta, kandi ifite uduce duto duto. Igipimo gisanzwe ni 0.5% kugeza 1.5%.

4 nkumuzitiro, umukozi urekura uhoraho hamwe numukozi utera pore

Urwego rwohejuru rwinshi rwibicuruzwa bikoreshwa mugutegura hydrophilique gel matrix ikomeza-kurekura ibinini, ibibuza hamwe nubugenzuzi-bwo kurekura ibikoresho bivanze na matrix ikomeza-kurekura, kandi bifite ingaruka zo gutinda kurekura ibiyobyabwenge. Ikoreshwa ryayo ni 10% ~ 80% (W / W). Amanota make-viscosity amanota akoreshwa nkibikoresho byo gukora pore kugirango irekure-irekure cyangwa igenzurwa-irekura. Igipimo cyambere gisabwa kugirango ingaruka zokuvura ubu bwoko bwibinini zirashobora kugerwaho vuba, hanyuma zikagira ingaruka zihoraho-zo kurekura cyangwa kugenzurwa-kurekura, kandi ibiyobyabwenge byamaraso bikomeza kugaragara mumubiri. Iyo hypromellose ihuye namazi, irayobora kugirango ikore geli. Uburyo bwo kurekura ibiyobyabwenge muri tablet ya matrix bikubiyemo cyane cyane ikwirakwizwa rya gel hamwe nisuri ya gel.

5 nkibibyimbye hamwe na koleoide ikingira

Iyo iki gicuruzwa gikoreshwa nkibibyimbye, ibisanzwe bikoreshwa ni 0.45% ~ 1.0%. Iki gicuruzwa nacyo gishobora kongera ituze rya hydrophobique glue, gukora colloide ikingira, ikabuza uduce duto guteranya no guteranya, bityo bikabuza kwibumbira mu myanda, kandi ubusanzwe ubusanzwe ni 0.5% ~ 1.5%.

6 nkibikoresho bya capsule

Mubisanzwe capsule shell capsule ibikoresho bya capsule bishingiye kuri gelatine. Igikorwa cyo gukora igikonoshwa cya gelatin capsule kiroroshye, ariko haribibazo bimwe na bimwe nko kurinda nabi imiti n’ibiyobyabwenge byangiza ogisijeni, umuvuduko muke w’ibiyobyabwenge, no gutinda gusenyuka kwa capsule mugihe cyo kubika. Kubwibyo, hypromellose, nkigisimbuza gelatine capsules, ikoreshwa mugutegura capsules, itezimbere imiterere nogukoresha capsules, kandi yazamuwe cyane mugihugu ndetse no mumahanga.

7 nka bioadhesive

Ikoranabuhanga rya Bioadhesion, gukoresha ibibyimba hamwe na polymeri ya bioadhesive, binyuze mu gufatira kuri mucosa biologique, byongera ubudahwema no gukomera kwimikoranire hagati yimyiteguro na mucosa, kuburyo imiti irekurwa buhoro buhoro kandi ikinjizwa na mucosa kugirango igere kubikorwa byo kuvura. Kugeza ubu irakoreshwa cyane Ikoreshwa mu kuvura indwara zifata izuru, mucosa yo mu kanwa nibindi bice. Ikoranabuhanga rya Gastrointestinal bioadhesion ni uburyo bushya bwo gutanga imiti bwakozwe mu myaka yashize. Ntabwo yongerera igihe cyo gutura imiti yimiti mungingo ya gastrointestinal, ahubwo inatezimbere imikorere yimikoranire hagati yibiyobyabwenge na selile ya selile aho yakira, ihindura amazi ya membrane selile, Kongera kwinjiza ibiyobyabwenge mumara. epithelial selile, bityo bitezimbere bioavailable yibiyobyabwenge.

8 nka jel yibanze

Nukwifata neza kuruhu, gel ifite urukurikirane rwibyiza nkumutekano, ubwiza, isuku yoroshye, igiciro gito, inzira yoroshye yo gutegura, hamwe no guhuza neza nibiyobyabwenge. icyerekezo.

9 nkumubyimba wibimera muri sisitemu ya emulisation