1. Ni ubuhe buryo bukoreshwa bwa hydroxypropyl methylcellulose (HPMC)?
—— Igisubizo: HPMC ikoreshwa cyane mubikoresho byubwubatsi, gutwikira, ibisigazwa byubukorikori, ububumbyi, ubuvuzi, ibiryo, imyenda, ubuhinzi, kwisiga, itabi nizindi nganda. HPMC irashobora kugabanywamo: icyiciro cyubwubatsi, urwego rwibiryo hamwe nu rwego rwa farumasi ukurikije imikoreshereze. Kugeza ubu, ibyinshi mubicuruzwa byo murugo ni urwego rwubwubatsi. Mu cyiciro cyubwubatsi, ifu ya putty ikoreshwa mubwinshi, hafi 90% ikoreshwa kubifu ya putty, naho ibindi bikoreshwa mumasima ya sima na kole.
2. Hariho ubwoko bwinshi bwa hydroxypropyl methylcellulose (HPMC), kandi ni irihe tandukaniro mugukoresha?
—— Igisubizo: HPMC irashobora kugabanywa muburyo bwubwoko nubwoko bushyushye. Ubwoko bwibicuruzwa bihita bikwirakwira vuba mumazi akonje bikabura mumazi. Muri iki gihe, amazi ntagira ubwiza, kubera ko HPMC ikwirakwizwa mu mazi gusa nta gushonga. Hafi yiminota 2, ubwiza bwamazi bugenda bwiyongera buhoro buhoro, bukora colloid ibonerana. Ibicuruzwa bishyushye, iyo bihuye namazi akonje, birashobora gukwirakwira vuba mumazi ashyushye bikabura mumazi ashyushye. Iyo ubushyuhe bugabanutse ku bushyuhe runaka, ibishishwa bizagaragara buhoro buhoro kugeza igihe bibumbiye mu mucyo. Ubwoko bushyushye burashobora gukoreshwa gusa mubifu ya pome na minisiteri. Muri kole yamazi no gusiga irangi, hazabaho guterana ibintu kandi ntibishobora gukoreshwa. Ubwoko bwakanya bufite intera yagutse ya porogaramu. Irashobora gukoreshwa mu ifu yuzuye ifu na minisiteri, hamwe na kole yamazi hamwe n irangi, nta kubuza.
3. Ni ubuhe buryo bwo gusesa hydroxypropyl methylcellulose (HPMC)?
—— Igisubizo: Uburyo bwo gushonga amazi ashyushye: Kubera ko HPMC idashonga mumazi ashyushye, HPMC irashobora gukwirakwizwa neza mumazi ashyushye mugihe cyambere, hanyuma igashonga vuba mugihe gikonje. Uburyo bubiri busanzwe busobanurwa gutya:
1) Shira amazi asabwa muri kontineri hanyuma uyashyuhe kuri 70 ° C. Hydroxypropyl methylcellulose yongeweho buhoro buhoro buhoro buhoro, mu ikubitiro HPMC ireremba hejuru y’amazi, hanyuma buhoro buhoro ikora ibibyimba, bikonjeshwa bikurura.
2), ongeramo 1/3 cyangwa 2/3 by'amazi asabwa muri kontineri, hanyuma ubishyuhe kugeza kuri 70 ° C, ukwirakwiza HPMC ukurikije uburyo bwa 1), hanyuma utegure amazi ashyushye; hanyuma shyiramo amazi asigaye asigaye mumazi ashyushye, imvange yarakonje nyuma yo gukurura.
Uburyo bwo kuvanga ifu: vanga ifu ya HPMC ninshi mubindi bintu byifu yifu, vanga neza na mixer, hanyuma ushyiremo amazi kugirango ushonga, hanyuma HPMC irashobora gushonga muriki gihe nta agglomeration, kuko muri HPMC nkeya gusa Inguni Ifu, izahita ishonga mugihe uhuye namazi. —— Ifu yuzuye ifu nabakora minisiteri bakoresha ubu buryo. [Hydroxypropyl methylcellulose (HPMC) ikoreshwa nk'umubyimba mwinshi kandi ugumana amazi muri pompe ya poro.
4. Nigute dushobora gusuzuma ubuziranenge bwa hydroxypropyl methylcellulose (HPMC) byoroshye kandi byihuse?
—— Igisubizo: (1) Kwera: Nubwo umweru udashobora kumenya niba HPMC yoroshye gukoresha, kandi niba ibikoresho byera byongewe mugihe cyibikorwa, bizagira ingaruka kumiterere yabyo. Nyamara, ibyinshi mubicuruzwa byiza bifite umweru mwiza. . . Ninini yohereza urumuri, nibyiza, byerekana ko harimo ibidashobora gukemuka muri byo. . Ubucucike bwa reaction ya vertical ni byiza muri rusange nibyiza, kandi nibya reaction ya horizontal ni bibi, ariko ntibisobanuye ko ubwiza bwa reaction ya vertical iruta iya reaction ya horizontal, kandi hariho ibintu byinshi byerekana ubwiza bwibicuruzwa . (4) Uburemere bwihariye: Ninini nini ya rukuruzi, niko iremereye. Umwihariko ni munini, muri rusange kubera ko ibiri mu itsinda rya hydroxypropyl muri yo ari byinshi, kandi ibikubiye mu itsinda rya hydroxypropyl ni byinshi, gufata amazi ni byiza.
5. Ni ubuhe buryo bukwiye bwa hydroxypropyl methylcellulose (HPMC)?
—— Igisubizo: Ifu ya putty muri rusange ni 100.000 Yuan, kandi ibisabwa kuri minisiteri ni byinshi, kandi 150.000 yuan birakenewe kugirango bikoreshwe byoroshye. Byongeye kandi, umurimo wingenzi wa HPMC nukubika amazi, ugakurikirwa no kubyimba. Mu ifu ya putty, mugihe cyose gufata amazi ari byiza kandi ibishishwa bikaba bike (70.000-80,000), birashoboka. Birumvikana ko hejuru yubukonje, niko gufata amazi ugereranije. Iyo ubwiza burenze 100.000, ubwiza buzagira ingaruka kumazi. Ntabwo ari byinshi.
6. Ni ibihe bimenyetso by'ingenzi bya tekinike ya hydroxypropyl methylcellulose (HPMC)?
—— Igisubizo: Hydroxypropyl ibirimo hamwe nubwiza, abakoresha benshi bahangayikishijwe nibi bipimo byombi. Abafite hydroxypropyl nyinshi muri rusange bafite amazi meza. Iyifite ubukonje bwinshi ifite gufata neza amazi, ugereranije (ntabwo rwose), naho iyifite ubukonje bwinshi ikoreshwa neza mumabuye ya sima.
7. Ni ibihe bikoresho by'ibanze bya hydroxypropyl methylcellulose (HPMC)?
—— Igisubizo: Ibikoresho nyamukuru bya hydroxypropyl methylcellulose (HPMC): ipamba inoze, methyl chloride, okiside ya propylene, nibindi bikoresho fatizo, soda ya caustic, aside, toluene, isopropanol, nibindi.
8.Ni uwuhe murimo w'ingenzi wo gukoresha HPMC mu ifu yuzuye, kandi bibaho mu buryo bwa shimi?
—— Igisubizo: Mu ifu yuzuye, HPMC ifite uruhare runini rwo kubyimba, gufata amazi no kubaka. Kubyimba: Cellulose irashobora kubyimba kugirango ihagarike kandi igumane igisubizo kimwe hejuru no hepfo, kandi irwanya kugabanuka. Kubika amazi: kora ifu ya putty yumye gahoro gahoro, kandi ufashe calcium yivu gukora mugihe cyamazi. Ubwubatsi: Cellulose ifite amavuta yo gusiga, ashobora gutuma ifu ya putty yubaka neza. HPMC ntabwo yitabira imiti iyo ari yo yose, ariko igira uruhare gusa. Ongeramo amazi kumashanyarazi hanyuma ukayashyira kurukuta nigisubizo cyimiti, kuko havutse ibintu bishya. Niba ukuyemo ifu ya putty kurukuta kurukuta, ukayisya ifu, ukongera ukayikoresha, ntabwo bizakora kuko havutse ibintu bishya (calcium karubone). ) na. Ibice byingenzi bigize ifu ya calcium yivu ni: imvange ya Ca (OH) 2, CaO hamwe na CaCO3 nkeya, CaO + H2O = Ca (OH) 2 - Ca (OH) 2 + CO2 = CaCO3 ↓ + H2O Kalisiyumu yivu iri mumazi no mwuka Mubikorwa bya CO2, karubone ya calcium ikorwa, mugihe HPMC igumana amazi gusa, ifasha reaction nziza ya calcium yivu, kandi ntabwo yitabira reaction ubwayo.
9. HPMC ni ether ya selile idafite ionic, none non-ionic niki?
—— Igisubizo: Mu magambo y’abalayiki, ibitari ion ni ibintu bidatera ioni mu mazi. Ionisation bivuga inzira electrolyte igabanyijemo ion zishishwa zishobora kugenda mubwisanzure mumashanyarazi yihariye (nk'amazi, inzoga). Kurugero, sodium chloride (NaCl), umunyu turya burimunsi, ushonga mumazi na ionize kugirango ubyare sodium yimuka yimuka kubuntu (Na +) byuzuye neza na ioni ya chloride (Cl) byashizwemo nabi. Nukuvuga ko, iyo HPMC ishyizwe mumazi, ntabwo izitandukanya na ion zashizwemo, ahubwo ibaho muburyo bwa molekile.
10. Ubushyuhe bwa gel bwa hydroxypropyl methylcellulose bufitanye isano niki?
—— Igisubizo: Ubushyuhe bwa gel bwa HPMC bujyanye nibirimo. Hasi ya mikorerexyxy ↓, nubushyuhe bwa gel.
11. Haba hari isano hagati yigitonyanga cyifu ya HPMC?
—— Igisubizo: Gutakaza ifu yifu ya putty bifitanye isano ahanini nubwiza bwa calcium yivu, kandi ntaho bihuriye na HPMC. Kalisiyumu nkeya ya calcium yumukara hamwe nigipimo kidakwiye cya CaO na Ca (OH) 2 muri calcium yumukara bizatera gutakaza ifu. Niba ifite aho ihuriye na HPMC, noneho niba HPMC ifite amazi mabi, bizatera no gutakaza ifu.
12. Ni irihe tandukaniro riri hagati yubwoko bwamazi akonje nubwoko bushyushye bwa hydroxypropyl methylcellulose mugikorwa cyo kubyara?
—— Igisubizo: Ubwoko bwamazi akonje bwa HPMC buvurwa hejuru na glyoxal, kandi bukwirakwira vuba mumazi akonje, ariko ntibishonga. Irashonga gusa iyo ububobere bwiyongereye. Ubwoko bushyushye ntibuboneka hejuru ya glyoxal. Niba ingano ya glyoxal ari nini, gutatanya bizihuta, ariko ubwiza bwiyongera buhoro, kandi niba umubare ari muto, ibinyuranye bizaba ukuri.
13. Impumuro ya hydroxypropyl methylcellulose (HPMC) ni ubuhe?
—— Igisubizo: HPMC yakozwe nuburyo bwo gukemura ikoresha toluene na isopropanol nkumuti. Niba gukaraba atari byiza cyane, hazabaho umunuko usigaye.
14. Nigute ushobora guhitamo hydroxypropyl methylcellulose (HPMC) kubwimpamvu zitandukanye?
—— Igisubizo: Gukoresha ifu ya putty: ibisabwa ni bike, kandi ibishishwa ni 100.000, birahagije. Icyangombwa nukubungabunga amazi neza. Gukoresha minisiteri: ibisabwa hejuru, viscosity nyinshi, 150.000 nibyiza. Gukoresha kole: ibicuruzwa byihuse hamwe nubwiza bwinshi birasabwa.
15. Irindi zina rya hydroxypropyl methylcellulose ni irihe zina?
—— Igisubizo: Hydroxypropyl Methyl Cellulose, Icyongereza: Hydroxypropyl Methyl Cellulose Amagambo ahinnye: HPMC cyangwa MHPC Alias: Hypromellose; Cellulose hydroxypropyl methyl ether; Hypromellose, Cellulose, 2-hydroxypropyl methyl Cellulose ether. Cellulose hydroxypropyl methyl ether Hyprolose.
16. Gukoresha HPMC mu ifu yuzuye, niyihe mpamvu itera ibibyimba mu ifu yuzuye?
—— Igisubizo: Mu ifu yuzuye, HPMC ifite uruhare runini rwo kubyimba, gufata amazi no kubaka. Ntukagire uruhare mubitekerezo byose. Impamvu zibibyimba: 1. Shyira amazi menshi. 2. Igice cyo hasi ntabwo cyumye, kuraho ikindi gice hejuru, kandi biroroshye kubira ifuro.
17. Ni irihe tandukaniro riri hagati ya HPMC na MC?
—— Igisubizo: MC ni methyl selulose, ikozwe muri ether ya selulose mu kuvura ipamba inoze hamwe na alkali, ukoresheje chloride metani nka agent ya etherification, kandi unyuze mubitekerezo. Mubisanzwe, urwego rwo gusimburwa ni 1.6 ~ 2.0, kandi gukemura nabyo biratandukanye hamwe nimpamyabumenyi zitandukanye zo gusimburwa. Nibya non-ionic selulose ether.
. Mubisanzwe, niba umubare wongeyeho ari munini, ubwiza ni buto, kandi ubwiza ni bunini, igipimo cyo gufata amazi ni kinini. Muri byo, ingano y’inyongera igira ingaruka zikomeye ku kigero cyo gufata amazi, kandi urwego rw’ubukonje ntiruhwanye neza n’urwego rwo gufata amazi. Igipimo cyo guseswa ahanini biterwa nurwego rwo guhindura isura ya selile na selile nziza. Muri ethers ya selile yavuzwe haruguru, methyl selulose na hydroxypropyl methyl selulose bifite igipimo kinini cyo gufata amazi.
(2) Methylcellulose irashonga mumazi akonje, kandi bizagorana gushonga mumazi ashyushye. Igisubizo cyamazi cyacyo kirahagaze neza murwego rwa pH = 3 ~ 12. Ifite guhuza neza na krahisi, guar gum, nibindi byinshi na surfactants. Iyo ubushyuhe bugeze ku bushyuhe bwa gelation, gelation iba.
(3) Imihindagurikire yubushyuhe izagira ingaruka zikomeye ku kigero cyo gufata amazi ya methyl selile. Mubisanzwe, uko ubushyuhe buri hejuru, niko gufata amazi ari bibi. Niba ubushyuhe bwa minisiteri burenze 40 ° C, kugumana amazi ya methyl selulose bizagabanuka cyane, bigira ingaruka zikomeye ku iyubakwa rya minisiteri.
(4) Methyl selulose igira ingaruka zikomeye mukubaka no gufatira minisiteri. "Gufatanya" hano bivuga imbaraga zifatika zumvwa hagati yumukozi usaba umukozi nu rukuta, ni ukuvuga kurwanya inkovu. Kwizirika hejuru ni byinshi, kurwanya inkweto za minisiteri ni nini, kandi imbaraga zisabwa n'abakozi mu gihe cyo gukoresha nazo ni nini, kandi imikorere ya minisiteri ikennye. Methyl selile yifata iri murwego ruciriritse mubicuruzwa bya selile.
HPMC ni hydroxypropyl methylcellulose, ikaba ari ether ya selulose ivanze ya ether ikozwe mu ipamba itunganijwe nyuma ya alkalisation, ikoresheje okiside ya propylene na methyl chloride nkibikoresho bya etherification, kandi binyuze mubitekerezo bitandukanye. Urwego rwo gusimbuza muri rusange ni 1.2 ~ 2.0. Imiterere yacyo iratandukanye bitewe numubare utandukanye wibintu bya mikorobe na hydroxypropyl.
(1) Hydroxypropyl methylcellulose irashobora gushonga byoroshye mumazi akonje, kandi izahura ningorane zo gushonga mumazi ashyushye. Ariko ubushyuhe bwacyo bwo mumazi ashyushye buri hejuru cyane ugereranije na methyl selile. Ubushyuhe bwo mumazi akonje nabwo buratera imbere cyane ugereranije na methyl selulose.
. Ubushyuhe nabwo bugira ingaruka ku bwenge bwabwo, uko ubushyuhe bwiyongera, ubukonje bugabanuka. Nyamara, ubukonje bwacyo bwinshi bugira ingaruka zubushyuhe burenze methyl selile. Igisubizo cyacyo gihamye iyo kibitswe mubushyuhe bwicyumba.
(3) Hydroxypropyl methylcellulose ihamye kuri aside na alkali, kandi igisubizo cyayo cyamazi kirahagaze neza murwego rwa pH = 2 ~ 12. Soda ya Caustic n'amazi ya lime ntacyo bihindura mubikorwa byayo, ariko alkali irashobora kwihutisha iseswa ryayo kandi ikongera ububobere bwayo. Hydroxypropyl methylcellulose ihagaze neza kumunyu usanzwe, ariko iyo ubunini bwumuti wumunyu mwinshi, ubwiza bwumuti wa hydroxypropyl methylcellulose bikunda kwiyongera.
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. Nka alcool ya polyvinyl, ibinyamisogwe ether, amase y'imboga, nibindi.
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18. Ni iki gikwiye kwitabwaho mugushira mubikorwa isano iri hagati yubukonje nubushyuhe bwa HPMC?
—— Igisubizo: Ubukonje bwa HPMC buringaniye butandukanye nubushyuhe, ni ukuvuga ko ubukonje bwiyongera uko ubushyuhe bugabanuka. Ubukonje bwibicuruzwa dukunze kuvuga bivuga ibisubizo byikizamini cyumuti wacyo wa 2% mubushyuhe bwa dogere selisiyusi 20.
Mubikorwa bifatika, twakagombye kumenya ko mubice bifite itandukaniro rinini ryubushyuhe hagati yizuba nimbeho, birasabwa gukoresha ubukonje buke ugereranije nimbeho, bifasha cyane kubaka. Bitabaye ibyo, iyo ubushyuhe buri hasi, ubukonje bwa selile buziyongera, kandi ukuboko kumva kuremereye mugihe cyo gukuraho.
Ubucucike buciriritse: 75000-100000 Ahanini bikoreshwa muri putty.
Impamvu: gufata neza amazi.
Ubukonje bwinshi: 150000-200000 Byakoreshejwe cyane cyane mubice bya polystirene yubushyuhe bwumuriro wa minisiteri ya kole hamwe na mikorobe ya vitamine ya vitamine.
Impamvu: ubukonje bwinshi, minisiteri ntabwo byoroshye kugwa, kumanika, no kunoza ubwubatsi.
Ariko muri rusange, uko ubukonje buri hejuru, niko gufata amazi ari byiza. Kubera iyo mpamvu, urebye ikiguzi, inganda nyinshi zumye zumye zisimbuza selile na selile nkeya (20000-40000) hamwe na selile ya selile (20000-40000) kugirango igabanye umubare wongeyeho. .
Igihe cyo kohereza: Ugushyingo-21-2022