Chifukwa chiyani HEMC ili yabwino kuposa HPMC?

Hypromellose (HPMC) ndi hydroxyethylmethylcellulose (HEMC) ndi zinthu ziwiri zomwe zimagwiritsidwa ntchito kwambiri ndi cellulose zomwe zimagwiritsidwa ntchito m'mafakitale opanga mankhwala, zakudya ndi zodzikongoletsera. Ngakhale HPMC ndi HEMC zimagawana zofanana zambiri, zimasiyana m'njira zina, zomwe zimapangitsa wina kukhala wapamwamba kuposa wina pamapulogalamu ena.

HEMC ndi ether yosinthidwa ya cellulose yomwe imapezeka pochita methyl cellulose ndi ethylene oxide ndi ethyl chloride, kenako m'malo mwa ethyl ya hydroxyl. Chifukwa chake, HEMC ili ndi digiri yapamwamba yolowa m'malo (DS) kuposa HPMC. DS imatanthawuza kuchuluka kwazinthu zolowa m'malo pamtundu uliwonse wa shuga, zomwe zimakhudza thupi ndi mankhwala a polima. Nthawi zambiri, DS yapamwamba imapangitsa kusungunuka kwabwinoko mu zosungunulira za organic, kusungunuka mwachangu, komanso kuchulukira kwamadzi. DS ya HEMC nthawi zambiri imakhala 1.7-2.0, pamene DS ya HPMC nthawi zambiri imakhala pakati pa 1.2 ndi 1.5.

Ubwino wapadera wa HEMC pa HPMC ndi mphamvu yake yabwino yosungira madzi, kupangitsa kuti ikhale yabwino pamapangidwe omatira, zida zomangira ndi zinthu zina zomwe zimafunikira kuti madzi asungidwe bwino. HEMC imakhalanso yolimbana ndi tizilombo toyambitsa matenda kuposa HPMC ndipo imakhala ndi nthawi yayitali. Kuwonjezeka kwa hydrophobicity ya HEMC ndi kukhalapo kwa magulu a ethyl m'mbuyo mwake kumapangitsa kukhala emulsifier yabwino kwambiri ndipo kungapangitse kukhazikika kwa nthawi yaitali kwa emulsions.

Ubwino wina wogwiritsa ntchito HEMC ndikugwirizana kwake ndi mankhwala ena ambiri, omwe amathandizira kuti azitha kusinthasintha pamagwiritsidwe osiyanasiyana. Kuphatikiza apo, HEMC ili ndi zinthu zabwino zopanga mafilimu, zomwe zimapangitsa kuti zikhale zothandiza popanga zokutira ndi zomangira popanga mapiritsi, mapiritsi ndi ma granules.

Kumbali inayi, HPMC ili ndi ma gelling abwinoko, zomwe zimapangitsa kukhala chisankho chabwino kwambiri pamapangidwe amankhwala otulutsidwa pang'onopang'ono omwe amafunikira ma gels osamva kutentha. HPMC alinso bwino madzi solubility ndi zochepa sachedwa kupanga coagglomerates, amene ndi insoluble aggregates wa ma polima mu njira.

Pomaliza, onse HEMC ndi HPMC ndizochokera ku cellulose zamtengo wapatali zomwe zimapereka maubwino osiyanasiyana kutengera ntchito. HEMC ili ndi madzi osungira bwino, emulsification, ndi kuyanjana ndi mankhwala ena, pamene HPMC ili ndi katundu wabwino kwambiri wa thermogelling ndi kusungunuka kwa madzi. Chifukwa chake, kusankha pakati pa HEMC ndi HPMC kumadalira pakugwiritsa ntchito komwe mukufuna, njira yopangira komanso zofunikira zomaliza.