Kodi pH ya HPMC ndi chiyani?

HPMC (Hydroxypropyl Methylcellulose, hydroxypropyl methylcellulose) ndi polima wosungunuka m'madzi womwe umagwiritsidwa ntchito kwambiri m'mafakitale opanga mankhwala, zakudya ndi zodzikongoletsera. Amagwiritsidwa ntchito makamaka ngati thickener, stabilizer, emulsifier, film-forming agent ndi control agent. Tulutsani zinthu. Mbali yake yayikulu ndikuti imatha kupanga njira yowonekera m'madzi ndipo imakhala ndi makulidwe abwino komanso kumamatira.

Mtengo wapatali wa magawo HPMC
HPMC palokha ilibe pH mtengo wokhazikika chifukwa ndi chinthu chosalowerera kapena acidic polima. HPMC ndi nonionic cellulose yochokera ku cellulose, kotero sizisintha kwambiri pH ya yankho. Akasungunuka m'madzi, pH ya yankho nthawi zambiri imadalira pH ya zosungunulira zokha m'malo mwa mankhwala a HPMC okha.

Nthawi zambiri, pH ya mayankho a HPMC imasiyana malinga ndi zosungunulira. Nthawi zambiri, pH ya mayankho a HPMC m'madzi oyeretsedwa ndi pafupifupi pakati pa 6.0 ndi 8.0. Ubwino wa madzi kuchokera ku magwero osiyanasiyana, komanso ma viscosity osiyanasiyana a HPMC, angakhudze pang'ono pH ya yankho lomaliza. Ngati kuli kofunikira kugwiritsa ntchito mayankho a HPMC mkati mwa mtundu wina wa pH, izi zitha kusinthidwa powonjezera ma buffer panthawi yopanga.

Zotsatira zakuthupi ndi zamankhwala za HPMC pa pH
Popeza HPMC ndi gulu losakhala la ionic ndipo ilibe magulu osakanikirana mu mamolekyu ake, sizikhudza mwachindunji pH ya yankho monga ma polima a cationic kapena anionic. Khalidwe la HPMC mu yankho limakhudzidwa makamaka ndi zinthu monga kutentha, kukhazikika, ndi mphamvu ya ionic.

Viscosity ndi kukhazikika kwa yankho: Gawo lofunikira la HPMC ndi kukhuthala kwake, kulemera kwake kwa maselo komwe kumatsimikizira momwe imakhalira yankho. PH ya HPMC yankho la low-viscosity HPMC likhoza kukhala pafupi ndi pH ya madzi okha (kawirikawiri pafupifupi 7.0), pamene yankho la HPMC lapamwamba kwambiri likhoza kukhala la acidic kapena lamchere pang'ono, malingana ndi kukhalapo kwa zonyansa kapena zowonjezera zina. mu yankho. .

Zotsatira za kutentha: Kukhuthala kwa mayankho a HPMC kumasintha ndi kutentha. Pamene kutentha ukuwonjezeka, ndi solubility wa HPMC ukuwonjezeka ndi mamasukidwe akayendedwe amachepetsa. Kusintha kumeneku sikukhudza mwachindunji pH ya yankho, koma kungasinthe madzi ndi mawonekedwe a yankho.

Kusintha kwa pH muzochitika zogwiritsira ntchito
Muzinthu zina zapadera, monga machitidwe owongolera otulutsa mankhwala kapena zowonjezera zakudya, pangakhale zofunikira zenizeni za pH. Pazifukwa izi, pH ya yankho la HPMC imatha kusinthidwa powonjezera ma asidi, maziko, kapena ma buffer. Mwachitsanzo, citric acid, phosphate buffer, etc. angagwiritsidwe ntchito kusintha pH ya yankho la HPMC kuonetsetsa bata ndi mphamvu ya mankhwala omaliza.

Kwa HPMC pakupanga mankhwala, kuwongolera pH ndikofunikira kwambiri chifukwa kusungunuka ndi kutulutsa kwamankhwala nthawi zambiri kumadalira pH ya chilengedwe. Chikhalidwe chosakhala cha ionic cha HPMC chimapangitsa kuti chiwonetsere kukhazikika kwamankhwala m'malo okhala ndi pH yosiyana, ndikupangitsa kuti ikhale yoyenera kugwiritsidwa ntchito pamapiritsi apakamwa, makapisozi, kukonzekera maso ndi mankhwala apakhungu.

Phindu la pH la HPMC palokha lilibe mtengo wokhazikika. PH yake imadalira kwambiri zosungunulira ndi njira yothetsera ntchito. Childs, pH wa HPMC njira m'madzi ranges kuchokera pafupifupi 6.0 kuti 8.0. M'machitidwe othandiza, ngati pH ya yankho la HPMC ikufunika kusinthidwa, imatha kusinthidwa ndikuwonjezera buffer kapena acid-base solution.