Hydroxypropylmethylcellulose (HPMC) ndi polima wopangira omwe amagwiritsidwa ntchito kwambiri omwe amapezeka muzinthu zosiyanasiyana kuphatikiza zodzoladzola, mankhwala, utoto ndi zakudya. Amapangidwa ndikusintha mapadi a cellulose pogwiritsa ntchito mankhwala a propylene oxide ndi methyl chloride. HPMC ali angapo zofunika katundu, monga sanali poizoni, sanali irritable, biodegradable, ndi biocompatible. Chimodzi mwazinthu zapadera ndi kuthekera kwake kukhudza kufalikira kwa kuwala. M'nkhaniyi, tikufufuza zinthu zosiyanasiyana zomwe zimapangitsa kuti ma HPMC akhudze mayendedwe opepuka komanso momwe angagwiritsire ntchito malowa.
Chimodzi mwazinthu zazikulu zomwe zimakhudza mphamvu yotumizira kuwala kwa HPMC ndi kapangidwe kake ka maselo. HPMC ndi polima wanthambi wopangidwa ndi cellulose ndi mayunitsi obwereza a methyl hydroxypropyl. Kulemera kwa mamolekyulu a HPMC kumadalira kuchuluka kwake (DS), kuchuluka kwa magulu a hydroxypropyl ndi methyl pa cellulose unit. HPMC yokhala ndi DS yapamwamba imakhala ndi magulu ochulukirapo a hydroxypropyl ndi methyl, zomwe zimapangitsa kulemera kwakukulu kwa mamolekyu komanso kukhudzidwa kwakukulu pakutumiza kwa kuwala.
Chinanso chofunikira chomwe chimakhudza kufalikira kwa kuwala ndi kuchuluka kwa HPMC mu yankho. Pamene HPMC imasungunuka m'madzi, njira yomveka komanso yowonekera imapangidwa pazigawo zochepa. Pamene ndende ikuwonjezeka, yankho limakhala lowoneka bwino kwambiri ndipo kutumizira kumachepa chifukwa cha kubalalika kwa kuwala. Kukula kwa zotsatirazi kumadalira kulemera kwa maselo, DS ndi kutentha kwa yankho.
Chinthu chachitatu chomwe chimakhudza kufalikira kwa kuwala ndi pH ya yankho. HPMC ndi amphoteric polima kuti akhoza kuchita ngati asidi ofooka ndi ofooka m'munsi, malinga pH ya yankho. Pa pH yotsika, magulu a hydroxypropyl ndi methyl pa HPMC amakhala opangidwa ndi protonated, zomwe zimapangitsa kuchepa kwa kusungunuka komanso kuchepetsa kufalikira kwa kuwala. Pa pH yapamwamba, msana wa cellulose wa HPMC umachotsedwa, zomwe zimapangitsa kuti kusungunuka kwachuluke komanso kufalikira kwa kuwala.
Chinthu chachinayi chomwe chimakhudza kufalikira kwa kuwala ndi kukhalapo kwa mankhwala ena monga mchere, surfactants ndi co-solvents. Mankhwalawa amatha kuyanjana ndi HPMC, kuchititsa kusintha kwa maselo ake ndi kusungunuka, potero kumakhudza kufala kwa kuwala. Mwachitsanzo, kuwonjezera mchere kumatha kuwonjezera mphamvu ya ionic ya yankho, zomwe zimapangitsa kuchepa kwa kusungunuka komanso kufalikira kwa kuwala. Kumbali inayi, kukhalapo kwa ma surfactants kumatha kusintha kugwedezeka kwapamtunda kwa yankho, zomwe zimapangitsa kuchepa kwa mamasukidwe akayendedwe komanso kuwonjezereka kwa kufalikira kwa kuwala.
Mphamvu zopatsira kuwala za HPMC zimakhala ndi ntchito zosiyanasiyana. M'makampani opanga mankhwala, HPMC imagwiritsidwa ntchito ngati thickener, binder ndi disintegrant mu mapiritsi ndi makapisozi. Kuthekera kwake kukhudza kufalikira kwa kuwala kumapangitsa kuti ikhale yothandiza ngati zinthu zokutira zomwe zimatha kuteteza zinthu zogwira ntchito kuchokera pakuwonongeka kopangidwa ndi kuwala. Mawonekedwe obalalika a HPMC amapangitsanso kukhala woyenera pamayendedwe oyendetsedwa operekera mankhwala omwe amafunikira kutulutsa kosalekeza kwa zosakaniza zomwe zimagwira ntchito.
Kuphatikiza pa mankhwala, mphamvu zowunikira za HPMC zimagwiritsidwanso ntchito m'makampani azakudya. HPMC imagwiritsidwa ntchito ngati choloweza mmalo chamafuta muzakudya zamafuta ochepa komanso zotsika kwambiri. Kuthekera kwake kupanga ma gels owoneka bwino komanso okhazikika munjira zamadzimadzi kumapangitsa kuti ikhale yoyenera pazinthu monga mavalidwe a saladi, mayonesi ndi sosi. Mphamvu zobalalitsa kuwala za HPMC zitha kugwiritsidwanso ntchito kupanga mawonekedwe amtambo mu zakumwa monga timadziti ta zipatso ndi zakumwa zamasewera.
Mwachidule, hydroxypropylmethylcellulose (HPMC) ndi polima wamtengo wapatali wopangira chifukwa cha mawonekedwe ake apadera, kuphatikiza kuthekera kokhudza kufalikira kwa kuwala. Zomwe zimakhudza kufalikira kwa kuwala kwa HPMC zimaphatikizapo kapangidwe kake ka maselo, ndende, pH, ndi kupezeka kwa zinthu zina. Mphamvu zotumiza kuwala za HPMC zili ndi ntchito zingapo zomwe zitha kugwiritsidwa ntchito m'mafakitale azamankhwala ndi zakudya, kuphatikiza kuperekera mankhwala osokoneza bongo komanso zakudya zopanda mafuta ambiri. Pomwe kafukufuku wazinthu za HPMC akupitilira, ntchito zambiri zitha kupezeka.
Nthawi yotumiza: Aug-02-2023