Hydroxypropylmethylcellulose (HPMC) ndi polima wotchuka yemwe amagwiritsidwa ntchito m'mafakitale monga mankhwala, zomangamanga, chakudya ndi chisamaliro chaumwini. Ndi mtundu wosinthidwa wa cellulose womwe umapezeka pochita methylcellulose ndi propylene oxide. HPMC ndi yoyera kapena yoyera, yopanda fungo, yopanda pake, yosungunuka mosavuta m'madzi, Mowa ndi zosungunulira zina organic. Pepalali likukambirana zazikuluzikulu zaukadaulo za HPMC.
mamasukidwe akayendedwe
Viscosity ndiye ndondomeko yofunikira kwambiri yaukadaulo ya HPMC, yomwe imatsimikizira momwe amayendera komanso momwe amagwirira ntchito m'mafakitale osiyanasiyana. HPMC ili ndi mamasukidwe apamwamba, zomwe zikutanthauza kuti ili ndi mawonekedwe owoneka ngati uchi. The mamasukidwe akayendedwe a HPMC akhoza kusinthidwa ndi kusintha mlingo wa m'malo magulu hydroxyl. Apamwamba digiri ya m'malo, ndi apamwamba mamasukidwe akayendedwe.
Digiri ya m'malo
The degree of substitution (DS) ndi chizindikiro china chofunikira chaukadaulo cha HPMC, chomwe chimatanthawuza kuchuluka kwa magulu a hydroxyl osinthidwa ndi magulu a hydroxypropyl ndi magulu a methyl. DS ya HPMC nthawi zambiri imakhala kuyambira 0.1 mpaka 1.7, pomwe DS yapamwamba ikuwonetsa kusinthidwa kwakukulu. DS ya HPMC imakhudza kusungunuka kwake, kukhuthala kwake ndi katundu wa gel.
kulemera kwa maselo
Kulemera kwa mamolekyu a HPMC ndichinthu chofunikira kwambiri chaukadaulo chomwe chimakhudza zinthu zake zakuthupi ndi zamankhwala monga solubility, viscosity, ndi gelation. HPMC nthawi zambiri imakhala ndi mamolekyu olemera a 10,000 mpaka 1,000,000 Daltons, okhala ndi zolemetsa zapamwamba zosonyeza maunyolo aatali a polima. Kulemera kwa mamolekyulu a HPMC kumakhudza kukhuthala kwake, luso lopanga filimu komanso mphamvu yosunga madzi.
Mtengo wapatali wa magawo PH
Phindu la pH la HPMC ndilofunika kwambiri laukadaulo lomwe limakhudza kusungunuka kwake komanso kukhuthala kwake. HPMC ndi sungunuka mu acidic ndi zamchere njira, koma mamasukidwe akayendedwe ake ndi apamwamba pansi acidic zinthu. PH ya HPMC ikhoza kusinthidwa powonjezera asidi kapena maziko. HPMC nthawi zambiri imakhala ndi pH pakati pa 4 ndi 9.
chinyezi
Chinyezi cha HPMC ndichinthu chofunikira kwambiri chaukadaulo chomwe chimakhudza kukhazikika kwake kosungirako komanso magwiridwe antchito. HPMC ndi hygroscopic, kutanthauza kuti zimatenga chinyezi mpweya. Chinyezi cha HPMC chiyenera kusungidwa pansi pa 7% kuti chitsimikizire kukhazikika kwake ndi ubwino wake. Kuchuluka kwa chinyezi kungayambitse kuyika kwa polima, kugwa komanso kuwonongeka.
Phulusa lazinthu
Phulusa la HPMC ndilofunika kwambiri laukadaulo lomwe limakhudza chiyero ndi mtundu wake. Phulusa limatanthawuza zotsalira za inorganic zomwe zimasiyidwa HPMC itawotchedwa. Phulusa la HPMC liyenera kukhala lochepera 7% kuti liwonetsetse chiyero ndi khalidwe lake. Phulusa lambiri limatha kuwonetsa kukhalapo kwa zonyansa kapena kuipitsidwa mu polima.
Gelation kutentha
Kutentha kwa gel osakaniza a HPMC ndi chizindikiro chofunikira chaukadaulo chomwe chimakhudza momwe ma gelisi amagwirira ntchito. HPMC akhoza gel osakaniza pansi zina kutentha ndi ndende zinthu. Kutentha kwa gelation kwa HPMC kungasinthidwe posintha kuchuluka kwa m'malo ndi kulemera kwa maselo. Kutentha kwa gelling kwa HPMC kumakhala 50 mpaka 90 ° C.
Pomaliza
Hydroxypropylmethylcellulose (HPMC) ndi polima wamitundumitundu wokhala ndi mawonekedwe osiyanasiyana. Zizindikiro zazikulu zaumisiri za HPMC zimaphatikizapo kukhuthala, kuchuluka kwa m'malo, kulemera kwa maselo, mtengo wa pH, kuchuluka kwa chinyezi, phulusa, kutentha kwa gelation, ndi zina zotere. Zizindikiro zaukadaulo izi zimakhudza thupi ndi mankhwala a HPMC ndikuzindikira momwe amagwirira ntchito m'mafakitale osiyanasiyana. Podziwa izi, titha kusankha mtundu woyenera wa HPMC kuti tigwiritse ntchito ndikuwonetsetsa kuti ndi yabwino komanso kukhazikika kwake.
Nthawi yotumiza: Sep-04-2023