Njira Yopanga Kumizidwa kwa Alkaline ya Hydroxypropyl Methyl Cellulose (HPMC)

Njira yomiza ya alkaline ndi njira yodziwika bwino yopangira hydroxypropyl methyl cellulose (HPMC). Njirayi imakhudza momwe mapadi amachitira ndi sodium hydroxide (NaOH) ndiyeno ndi propylene oxide (PO) ndi methyl chloride (MC) nthawi zina.

Njira yomiza yamchere imakhala ndi mwayi wopanga HPMC yokhala ndi m'malo mwapamwamba (DS), yomwe imatsimikizira zinthu zake monga kusungunuka, kukhuthala, ndi kutsekemera. Njirayi ili ndi njira zotsatirazi:

1. Kukonzekera kwa Cellulose

Cellulose imapezeka kuzinthu zachilengedwe monga nkhuni, thonje, kapena zomera zina. Ma cellulose amayamba kuyeretsedwa kenako kuthandizidwa ndi NaOH kuti apange sodium cellulose, yomwe imakhala yapakatikati popanga HPMC.

2. Kuchita kwa Sodium Cellulose ndi Propylene Oxide (PO)

Sodium cellulose imayendetsedwa ndi PO pamaso pa chothandizira monga tetramethylammonium hydroxide (TMAH) kapena sodium hydroxide (NaOH) pa kutentha kwakukulu ndi kupanikizika. Zotsatira zake zimapangitsa kupanga hydroxypropyl cellulose (HPC).

3. Kuchita kwa HPC ndi Methyl Chloride (MC)

HPC imakhudzidwa ndi MC pamaso pa chothandizira monga sodium hydroxide (NaOH) kapena hydrochloric acid (HCl). Zotsatira zake zimapangitsa kupanga hydroxypropyl methyl cellulose (HPMC).

4. Kuchapa ndi Kuyanika

Zitachitika, mankhwalawa amatsukidwa ndi madzi ndikuwumitsa kuti apeze HPMC. Mankhwalawa nthawi zambiri amayeretsedwa pogwiritsa ntchito njira zosefera ndi centrifugation kuchotsa zonyansa zilizonse.

Njira yomiza ya alkaline ili ndi maubwino angapo kuposa njira zina, kuphatikiza DS wapamwamba ndi ukhondo, zotsika mtengo, komanso zosavuta. Njirayi ingagwiritsidwenso ntchito kupanga HPMC yokhala ndi katundu wosiyanasiyana posintha momwe zinthu zimachitikira monga kutentha, kuthamanga, komanso ndende.

Komabe, njirayi ilinso ndi zovuta zina. Kugwiritsiridwa ntchito kwa NaOH ndi MC kungayambitse ngozi ndi chitetezo cha chilengedwe, ndipo kupanga kupanga kungakhale nthawi yambiri ndipo kumafuna mphamvu zambiri.

Pomaliza, njira yopanga kumizidwa zamchere ndi njira yomwe imagwiritsidwa ntchito kwambiri popanga HPMC. Njirayi imakhudza momwe cellulose amachitira ndi NaOH, PO, ndi MC pansi pazifukwa zina, zotsatiridwa ndi kuyeretsedwa ndi kuyanika. Ngakhale kuti njirayi ili ndi zovuta zina, ubwino wake umapangitsa kukhala chisankho chodziwika bwino cha mafakitale ndi mankhwala.