Pangani Hand Sanitizer Gel pogwiritsa ntchito HPMC m'malo mwa Carbomer

Gelasi ya sanitizer pamanja yakhala chinthu chofunikira kwambiri pamoyo wathu watsiku ndi tsiku, makamaka panthawi ya mliri wa COVID-19. Zomwe zimagwira pamanja za sanitizer gel nthawi zambiri zimakhala mowa, womwe umathandiza kupha mabakiteriya ndi ma virus m'manja. Komabe, kuti apange mawonekedwe a gel, chowonjezera chimafunika kuti chikhale chokhazikika ngati gel. Carbomer ndi chinthu chokhuthala chomwe chimagwiritsidwa ntchito kwambiri pamapangidwe a gel osakaza m'manja, koma zitha kukhala zovuta kupeza ndipo wawona kukwera kwamitengo chifukwa cha mliri. M'nkhaniyi, tikambirana momwe tingapangire gel osakaniza m'manja pogwiritsa ntchito Hydroxypropyl Methylcellulose (HPMC) m'malo mwa carbomer.

Hydroxypropyl Methylcellulose (HPMC) ndi chochokera ku cellulose chomwe chili ndi ntchito zosiyanasiyana, kuphatikiza ngati thickener, binder, ndi emulsifier. HPMC ndi polima wosungunuka m'madzi womwe umatha kukhuthala m'madzi, ndikupangitsa kukhala njira yabwino yopangira carbomer m'manja mwa sanitizer gel. HPMC imapezekanso mosavuta komanso yotsika mtengo kuposa carbomer, ndikupangitsa kuti ikhale njira yabwino kwa opanga.

Kuti mupange gel osakaniza pamanja pogwiritsa ntchito HPMC, zosakaniza ndi zida zotsatirazi ndizofunikira:

Zosakaniza:

Isopropyl mowa (kapena ethanol)
Hydrogen peroxide
Glycerin
Hydroxypropyl Methylcellulose (HPMC)
Madzi osungunuka

Zida:

Kusakaniza mbale
Kusakaniza ndodo kapena chosakaniza magetsi
Kuyeza makapu ndi makapu
pH mita
Chidebe chosungiramo gel osakaniza m'manja

Khwerero 1: Yezerani Zosakaniza Muyeso zotsatirazi:

Mowa wa Isopropyl (kapena ethanol): 75% ya voliyumu yomaliza
Hydrogen peroxide: 0.125% ya voliyumu yomaliza
Glycerin: 1% ya voliyumu yomaliza
HPMC: 0.5% ya voliyumu yomaliza
Madzi osungunuka: voliyumu yotsala

Mwachitsanzo, ngati mukufuna kupanga 100ml ya gel osakaniza pamanja, muyenera kuyeza:

Mowa wa Isopropyl (kapena ethanol): 75ml
Hyrojeni peroxide: 0.125ml
Glycerin: 1 ml
HPMC: 0.5ml
Madzi osungunuka: 23.375ml

Gawo 2: Sakanizani Zosakaniza Sakanizani mowa wa isopropyl (kapena ethanol), hydrogen peroxide, ndi glycerin pamodzi mu mbale yosakaniza. Sakanizani zosakanizazo mpaka zitaphatikizidwa bwino.

Khwerero 3: Onjezani HPMC Pang'onopang'ono onjezani HPMC kusakaniza ndikuyambitsa mosalekeza. Ndikofunika kuwonjezera HPMC pang'onopang'ono kuti mupewe kugwa. Pitirizani kuyambitsa mpaka HPMC itabalalika kwathunthu ndipo kusakaniza kuli kosalala.

Khwerero 4: Onjezani Madzi Onjezani madzi osungunuka kusakaniza ndikuyambitsa mosalekeza. Pitirizani kuyambitsa mpaka kusakaniza kusakanikirana bwino.

Khwerero 5: Yang'anani pH Yang'anani pH ya osakaniza pogwiritsa ntchito pH mita. pH iyenera kukhala pakati pa 6.0 ndi 8.0. Ngati pH ili yotsika kwambiri, onjezerani pang'ono sodium hydroxide (NaOH) kuti musinthe pH.

Khwerero 6: Sakanizaninso Sakanizaninso kusakaniza kuti zonse zosakaniza zaphatikizidwa.

Khwerero 7: Tumizani ku Chidebe Chotsani gel osakaniza m'manja ku chidebe kuti musunge.

Geli ya sanitizer yobwera chifukwa chake iyenera kukhala yosalala, yofanana ndi gel yomwe imakhala yosavuta kugwiritsa ntchito m'manja. HPMC imagwira ntchito ngati thickener ndipo imapanga kukhazikika ngati gel, mofanana ndi carbomer. Geli ya sanitizer yobwera chifukwa chake iyenera kukhala yothandiza kupha mabakiteriya ndi ma virus m'manja, monga ma gels otsukira m'manja omwe amapezeka pamalonda.

Production practices (GMP) ndi malangizo ndi mfundo zomwe zimawonetsetsa kuti mankhwala azitsamba amakhala abwino komanso otetezeka, kuphatikiza gel osakaniza pamanja. Malangizowa amakhudza mbali zosiyanasiyana za ntchito yopangira, kuphatikizapo ogwira ntchito, malo, zipangizo, zolemba, kupanga, kulamulira khalidwe, ndi kugawa.

Mukamapanga gel osakaniza m'manja pogwiritsa ntchito HPMC kapena chinthu china chilichonse chokhuthala, ndikofunikira kutsatira malangizo a GMP kuti muwonetsetse kuti chinthucho chili bwino komanso chitetezo chake. Mfundo zazikuluzikulu za GMP zomwe ziyenera kutsatiridwa popanga gel osakaniza m'manja ndi monga:

Ogwira ntchito: Onse ogwira nawo ntchito popanga zinthu ayenera kukhala ophunzitsidwa bwino komanso oyenerera ntchito zawo. Ayeneranso kudziwa malangizo a GMP ndikuwatsata mosamalitsa.
Malo: Malo opangira zinthu ayenera kukhala aukhondo, osamalidwa bwino komanso okonzedwa kuti asaipitsidwe. Malowa ayenera kukhala ndi mpweya wokwanira komanso wowunikira, ndipo zida zonse ziyenera kuyesedwa bwino ndikutsimikiziridwa.
Zida: Zida zonse zomwe zimagwiritsidwa ntchito popanga ziyenera kutsukidwa ndikusamalidwa nthawi zonse kuti zisawonongeke. Zida ziyeneranso kutsimikiziridwa kuti zikugwira ntchito moyenera komanso kuti zimabweretsa zotsatira zofananira.
Zolemba: Njira zonse zopangira ziyenera kulembedwa bwino, kuphatikiza ma batch records, standard operating procedures (SOPs), and quality control records. Zolemba ziyenera kukhala zomveka bwino komanso zolondola kuti zitsimikizire kutsatiridwa ndi kuyankha.
Kupanga: Njira yopangira zinthu iyenera kutsata njira yodziwika bwino komanso yovomerezeka yomwe imatsimikizira kukhazikika kwazinthu komanso kuyera kwazinthu. Zida zonse zomwe zimagwiritsidwa ntchito popanga ziyenera kudziwika bwino, kutsimikiziridwa, ndikusungidwa.
Kuwongolera Ubwino: Njira zowongolera upangiri ziyenera kuchitika kuwonetsetsa kuti chomaliza chikukwaniritsa zofunikira. Kuwongolera kwaubwino kuyenera kukhala ndi kuyezetsa kuti ndani, chiyero, mphamvu, ndi zina zofunika.
Kugawa: Chomalizidwacho chiyenera kupakidwa bwino, cholembedwa, ndi kusungidwa kuti chipewe kuipitsidwa ndi kusunga kukhulupirika kwake. Njira yogawa iyenera kulembedwa bwino, ndipo zotumizidwa zonse ziyenera kutsatiridwa bwino ndikuwunikidwa.

Potsatira malangizo a GMP awa, opanga amatha kuwonetsetsa kuti zida zawo za gel osakaniza m'manja ndi zapamwamba komanso zotetezeka kuti zigwiritsidwe ntchito. Malangizowa amathandizanso kuwonetsetsa kusasinthika komanso kudalirika pakupanga, zomwe ndizofunikira kuti zikwaniritse kufunikira kwa gel osakaniza m'manja pa nthawi ya mliri wa COVID-19.

Pomaliza, Hydroxypropyl Methylcellulose (HPMC) itha kugwiritsidwa ntchito ngati choloweza m'malo mwa carbomer m'manja mwa sanitizer gel formulations. HPMC ndi njira yotsika mtengo komanso yopezeka mosavuta yomwe ingapereke mawonekedwe ofanana ndi makulidwe a carbomer. Mukamapanga gel osakaniza m'manja pogwiritsa ntchito HPMC, ndikofunikira kutsatira malangizo a GMP kuti muwonetsetse kuti chinthucho ndichabwino komanso chitetezo. Potsatira malangizowa, opanga amatha kupanga gel osakaniza m'manja omwe amatha kupha mabakiteriya ndi ma virus m'manja, ndikuwonetsetsa chitetezo cha wogwiritsa ntchito.

Nthawi yotumiza: Mar-18-2023