Hydroxypropyl methylcellulose amagwiritsidwa ntchito m'mapiritsi

Hydroxypropyl methylcellulose (HPMC) ndi chothandizira chomwe chimagwiritsidwa ntchito muzamankhwala, kuphatikiza mapiritsi. HPMC ndi polima yopangidwa ndi cellulose yomwe imasungunuka m'madzi ndipo imakhala ndi zinthu zosiyanasiyana zomwe zimapangitsa kuti ikhale yothandiza pamapangidwe a piritsi. Nkhaniyi tikambirana za HPMC ndi ntchito zake zosiyanasiyana pakupanga piritsi.

Katundu wa HPMC:

HPMC ndi hydrophilic polima kuti angagwiritsidwe ntchito ngati binder, thickener, stabilizer, ndi emulsifier. Ili ndi kulemera kwakukulu kwa maselo ndi digiri yapamwamba ya m'malo (DS), yomwe imakhudza kusungunuka kwake ndi kukhuthala kwake. HPMC akhoza kusungunuka m'madzi kapena mowa, koma si sungunuka zambiri organic solvents. Ilinso yopanda poizoni, yosakwiyitsa, komanso yopanda allergenic, ndikupangitsa kuti ikhale chisankho choyenera pakugwiritsa ntchito mankhwala.

Kugwiritsa ntchito HPMC pamapiritsi:

1. Binder:

HPMC imagwiritsidwa ntchito ngati binder pamapangidwe a piritsi. Imawonjezedwa ku ma granules a piritsi kuti agwirizanitse pamodzi ndikuwaletsa kuti asagwe. HPMC angagwiritsidwe ntchito payekha kapena osakaniza zomangira ena, monga microcrystalline mapadi (MCC), kusintha piritsi kuuma ndi friability.

2. Disintegrant:

HPMC itha kugwiritsidwanso ntchito ngati disintegrant mu mapiritsi. Mankhwala opha tizilombo amawonjezedwa pamapiritsi kuti awathandize kusweka ndi kusungunuka mwamsanga m'matumbo a m'mimba. HPMC imagwira ntchito ngati disintegrant potupa m'madzi ndikupanga ngalande kuti madzi alowe mu piritsi. Izi zimathandiza kupatutsa piritsi ndikutulutsa chogwiritsira ntchito.

3. Kutulutsidwa kolamulidwa:

HPMC imagwiritsidwa ntchito popanga mapiritsi oyendetsedwa bwino kuti azitha kutulutsa zomwe zimagwira. HPMC imapanga gel wosanjikiza kuzungulira piritsi, yomwe imayang'anira kutulutsidwa kwa zomwe zimagwira. Makulidwe a gel wosanjikiza amatha kuwongoleredwa posintha DS ya HPMC, yomwe imakhudza kukhuthala ndi kusungunuka kwa polima.

4. Kupaka filimu:

HPMC imagwiritsidwanso ntchito ngati chotchingira filimu pamapangidwe a piritsi. Kupaka filimu ndi njira yogwiritsira ntchito kagawo kakang'ono ka polima pamwamba pa piritsi kuti iwoneke bwino, iteteze ku chinyezi, ndi kubisa kukoma kwake. HPMC ingagwiritsidwe ntchito yokha kapena kuphatikiza ndi othandizira ena opanga mafilimu, monga polyethylene glycol (PEG), kuti apititse patsogolo mafilimu opanga mafilimu.

5. Woyimitsidwa:

HPMC amagwiritsidwanso ntchito ngati wothandizila kuyimitsidwa mu formulations madzi. Itha kugwiritsidwa ntchito kuyimitsa tinthu tating'onoting'ono mumadzi kuti tiyimitse kuyimitsidwa kokhazikika. HPMC ntchito ndi kupanga wosanjikiza zoteteza kuzungulira particles, kuwaletsa agglomerating ndi kukhazikika pansi pa chidebe.

Pomaliza:

Hydroxypropyl methylcellulose ndi polima wosunthika yemwe ali ndi ntchito zosiyanasiyana pamapangidwe a piritsi. Itha kugwiritsidwa ntchito ngati binder, disintegrant, control-release agent, film-coating agent, and suspension agent. Makhalidwe ake omwe alibe poizoni, osakwiyitsa, komanso osakhala a allergenic amawapanga kukhala chisankho choyenera pakugwiritsa ntchito mankhwala. The zimatha HPMC akhoza ogwirizana ndi kusintha mlingo wa m'malo, kupangitsa kukhala kusintha polima kuti angagwiritsidwe ntchito zosiyanasiyana piritsi formulations.