Hydroxypropylmethylcellulose (HPMC) ndi etha ya cellulose yomwe imagwiritsidwa ntchito kwambiri m'mafakitale angapo monga mankhwala, zodzoladzola, chakudya, ndi zomangamanga. Chifukwa cha kusinthasintha kwake komanso zopindulitsa, HPMC yakhala chinthu chodziwika bwino pamapangidwe osiyanasiyana. Pakadali pano, pali mitundu ingapo ya ma HPMC pamsika, iliyonse ili ndi katundu ndi ntchito zake.
HPMC ndi mankhwala kusinthidwa cellulose polima analandira pochita mapadi ndi methyl kolorayidi ndi propylene okusayidi. Izi zimabweretsa magulu a methyl ndi hydroxypropyl mu cellulose, kupanga polima wosungunuka m'madzi, wopanda ionic komanso wochita bwino kwambiri. Komabe, mitundu yosiyanasiyana ya HPMC ili ndi magawo osiyanasiyana olowa m'malo (DS) amagulu a methyl ndi hydroxypropyl, omwe amatsimikizira zomwe ali ndi thupi komanso mankhwala.
Nthawi zambiri, zinthu za HPMC zimagawidwa molingana ndi kukhuthala komanso mtengo wa DS. Viscosity ndi chinthu chofunikira kwambiri cha HPMC chifukwa chimakhudza kusungunuka kwa chinthucho, kupanga filimu komanso kuthekera kokulirakulira. Kumbali ina, mtengo wa DS umatsimikizira kuchuluka kwa polima m'malo mwake motero kuchuluka kwa hydrophobicity ya mtundu wa HPMC. Chifukwa chake, mitundu yosiyanasiyana ya HPMC imachokera kumitundu yosiyanasiyana yamakayendedwe awo ndi ma DS. Pansipa pali mitundu yodziwika bwino ya HPMC komanso momwe imasiyana.
1. Wamba kalasi HPMC
Common grade HPMC ili ndi methyl DS kuyambira 0.8 mpaka 2.0 ndi hydroxypropyl DS kuyambira 0.05 mpaka 0.3. Mtundu uwu wa HPMC umapezeka m'makalasi osiyanasiyana a viscosity kuyambira 3cps mpaka 200,000cps. Common grade HPMC imakhala ndi kusungunuka kwabwino m'madzi ndipo imapanga mayankho omveka bwino, ndikupangitsa kuti ikhale yoyenera kugwiritsidwa ntchito m'mafakitale azakudya, zamankhwala ndi zodzikongoletsera. Ma HPMC oterowo amagwiritsidwa ntchito ngati opanga mafilimu, zonenepa, zopangira ma emulsifiers ndi zolimbitsa thupi muzakudya ndi zodzoladzola.
2. Low m'malo HPMC
HPMC yolowa m'malo yotsika ili ndi digiri yotsika ya methyl ndi hydroxypropyl m'malo kuposa HPMC yanthawi zonse. Mtundu uwu wa HPMC uli ndi methyl DS kuyambira 0.2 mpaka 1.5 ndi hydroxypropyl DS kuyambira 0.01 mpaka 0.2. Otsika olowa m'malo mankhwala a HPMC amakhala otsika mamasukidwe akayendedwe, kawirikawiri pakati 3-400cps, ndipo kwambiri kugonjetsedwa ndi mchere ndi michere. Zinthu izi zimapangitsa kuti HPMC ikhale yocheperako m'malo mwa zinthu monga mkaka, zophika buledi ndi nyama. Kuphatikiza apo, HPMC yolowa m'malo otsika imagwiritsidwanso ntchito ngati chomangira, chophatikizira komanso chopaka mapiritsi pamafakitale azamankhwala.
3. High m'malo HPMC
Mkulu digiri ya m'malo HPMC ali ndi digiri yapamwamba ya methyl ndi hydroxypropyl m'malo kuposa wamba kalasi HPMC. Mtundu uwu wa HPMC uli ndi methyl DS kuyambira 1.5 mpaka 2.5 ndi hydroxypropyl DS kuyambira 0.1 mpaka 0.5. Zogulitsa za HPMC zosinthidwa kwambiri zimakhala ndi kukhuthala kwakukulu, kuyambira 100,000cps mpaka 200,000cps, ndipo zimakhala ndi mphamvu zosungira madzi. Izi zimapanga HPMC yosinthidwa kukhala yabwino kuti igwiritsidwe ntchito pantchito yomanga, monga zinthu zopangidwa ndi simenti, zokutira ndi zomatira. HPMC yolowetsedwa kwambiri imagwiritsidwanso ntchito ngati binder, thickener ndi kumasula mu makampani opanga mankhwala.
4. Methoxy-Ethoxy HPMC
Methoxy-Ethoxy HPMC ndi mtundu wopangidwa mwapadera wa HPMC wokhala ndi digiri yapamwamba ya m'malo mwa ethoxy. Magulu a ethoxy amawonjezera hydrophobicity ya HPMC, ndikupangitsa kuti ikhale yosungunuka m'madzi kuposa kalasi yanthawi zonse ya HPMC. Ndi methyl DS kuyambira 1.5 mpaka 2.5 ndi ethoxy DS kuyambira 0.4 mpaka 1.2, methoxy-ethoxy HPMC ndi yabwino kugwiritsidwa ntchito mu mafuta opangira mafuta monga zodzoladzola, utoto ndi zokutira. Mtundu uwu wa HPMC umapanga filimu yokhazikika komanso yofanana yomwe imapereka mapeto osalala, onyezimira kumalo omaliza.
5. Granular HPMC
Granular HPMC ndi mtundu wa HPMC womwe uli ndi tinthu tating'ono, nthawi zambiri pakati pa 100-200 microns. Granular HPMC imagwiritsidwa ntchito m'makampani opanga mankhwala ngati chomangira piritsi, chosokoneza komanso chotulutsa chokhazikika. Tinthu tating'onoting'ono ta HPMC tinthu tating'onoting'ono timalola kugawa ngakhale zosakaniza, zomwe zimapangitsa kuti pakhale chinthu chokhazikika komanso chodalirika. Granular HPMC ili ndi methyl DS kuyambira 0.7 mpaka 1.6 ndi hydroxypropyl DS kuyambira 0.1 mpaka 0.3.
Hydroxypropylmethylcellulose (HPMC) ndi polima wamitundumitundu wokhala ndi ntchito zambiri m'mafakitale osiyanasiyana. Mitundu ya HPMC imayikidwa molingana ndi kukhuthala ndi mtengo wa DS, zomwe zimatsimikizira zomwe zili mthupi komanso mankhwala. HPMC yanthawi zonse, HPMC yolowa m'malo yochepa, HPMC, methoxyethoxy HPMC ndi granular HPMC ndi mitundu yodziwika bwino ya HPMC. Kumvetsetsa kusiyana kwa mitunduyi kudzalola opanga ma formula kuti agwiritse ntchito mphamvu zonse za HPMCs kupanga zinthu zapamwamba komanso zomaliza zamphamvu.
Nthawi yotumiza: Sep-06-2023