Zinthu zomwe zimakhudza kukhuthala kwa hydroxypropyl methylcellulose

Hydroxyl methyl cellulose (HPMC) ndi polima yomwe imagwiritsidwa ntchito kwambiri mu mankhwala, zodzoladzola, chakudya ndi mafakitale ena. Zake wapadera mbali, monga mkulu mamasukidwe akayendedwe, madzi abwino - sungunuka ndi nembanemba mapangidwe luso, kupangitsa chigawo chofunika mu njira zosiyanasiyana. Kukhuthala ndi gawo lofunikira la HPMC pakugwiritsa ntchito kwake. Kukhuthala kwa HPMC kumakhudzidwa ndi zinthu zosiyanasiyana, monga ndende, kutentha, pH, ndi kulemera kwa maselo. Kumvetsetsa zomwe zimakhudza kukhuthala kwa HPMC ndikofunikira pakukhathamiritsa. Nkhaniyi ikufotokoza zomwe zimakhudza kukhuthala kwa hydroxylopyl methyl cellulose.

Onani kwambiri pa

Kuchuluka kwa HPMC ndi chimodzi mwazinthu zazikulu zomwe zimakhudza kukhuthala kwake. Kukhuthala kwa njira ya HPMC kumawonjezeka ndikuwonjezeka kwa ndende. Pam'munsi ndende, ndi HPMC polima unyolo ambiri anamwazikana mu zosungunulira, kotero mamasukidwe akayendedwe ndi otsika. Komabe, pamtunda wapamwamba, unyolo wa polima umakonda kuyanjana wina ndi mzake, zomwe zimapangitsa kukhuthala kwakukulu. Choncho, mamasukidwe akayendedwe a HPMC ndi molingana ndi ndende ya polima. Kukhazikika kumakhudzanso machitidwe a HPMC gelization. High-concentration HPMC ikhoza kupanga gel osakaniza, omwe ndi ofunika kwambiri pamakampani opanga mankhwala ndi zakudya.

kutentha

Kutentha ndi chinthu china chofunikira chomwe chimakhudza kukhuthala kwa hydroxylopenyl cellulose. Kukhuthala kwa HPMC kumachepa ndi kuwonjezeka kwa kutentha. The HPMC polima unyolo amakhala otaya kwambiri pa kutentha apamwamba, chifukwa otsika mamasukidwe akayendedwe. Poyerekeza ndi mayankho okwera kwambiri, momwe kutentha kwa HPMC mamasukidwe akayendedwe kumawonekera kwambiri munjira yotsika. Kuwonjezeka kwa kutentha kudzakhudzanso kusungunuka kwa HPMC. Pa kutentha kwakukulu, kusungunuka kwa HPMC kumachepa, zomwe zimapangitsa kuchepa kwa mamasukidwe akayendedwe chifukwa cha kuchepa kwa unyolo.

pH

PH ya yankho la HPMC ndi chinthu china chofunikira chomwe chimakhudza kukhuthala kwake. HPMC ndi polima ofooka acidic, ndi PKA pafupifupi 3.5. Chifukwa chake, kukhuthala kwa yankho la HPMC kumakhudzidwa ndi pH ya yankho. Pansi pa pH yamtengo wapatali kuposa PKA, gulu la mchere la carboxylic acid la polima lidakhala ndi protonization, zomwe zidapangitsa kuti kusungunuka kwa HPMC kuchuluke, komanso kukhuthala kwake kunachepetsedwa chifukwa cha kuchepa kwa ma hydrogen bond of the molecular interconsiscence. Pansi pa pH mtengo pansi pa PKA, gulu la carboxylic acid la polima linali lolemera, zomwe zinayambitsa kusungunuka kochepa komanso kukhuthala kwakukulu chifukwa cha kuchuluka kwa ma hydrogen. Chifukwa chake, mtengo wabwino kwambiri wa pH wa yankho la HPMC umadalira ntchito yomwe ikuyembekezeka.

Kulemera kwa maselo

Kulemera kwa maselo a HPMC ndi chinthu china chofunikira chomwe chimakhudza kukhuthala kwake. HPMC ndi polima polima. Pamene kulemera kwa maselo a polima kumawonjezeka, kukhuthala kwa njira ya HPMC kudzawonjezeka. Izi ndichifukwa choti unyolo wolemera kwambiri wa HPMC umakhala wokhazikika, zomwe zimapangitsa kukhuthala kwamphamvu. Kulemera kwa maselo a polima kumakhudzanso HPMC gelization. HPMC polima ndi zotheka kupanga gels kuposa otsika maselo kulemera ma polima.

Mchere

Kuonjezera mchere ku HPMC yankho kungakhudze kwambiri mamasukidwe ake. Mchere umakhudza mphamvu ya ion ya yankho la HPMC, lomwe limasintha kuyanjana kwa ma polima. Nthawi zambiri, kuwonjezera mchere ku yankho la HPMC kumapangitsa kuti kukhuthala kuchepe. Izi ndichifukwa choti mphamvu ya ayoni yankho imachepa pakati pa mphamvu yama cell pakati pa unyolo wa polima wa HPMC, potero kuchepetsa kutsekeka kwa unyolo, kotero kukhuthala kumachepetsedwa. Zotsatira za mchere pa kukhuthala kwa HPMC njira zimadalira mtundu ndi kuchuluka kwa mchere.

Pomaliza

Kukhuthala kwa hydroxydal cibolin ndi gawo lofunikira lomwe limakhudza ntchito yake m'mafakitale osiyanasiyana. Zomwe zimakhudza kukhuthala kwa HPMC zimaphatikizapo kukhazikika, kutentha, pH, kulemera kwa maselo ndi mchere. Kumvetsetsa zinthu izi pa HPMC mamasukidwe akayendedwe n'kofunika kukhathamiritsa ntchito zake zosiyanasiyana ntchito. Yankho la HPMC likhoza kusinthidwa moyenera kuti likwaniritse mamasukidwe ofunikira omwe ali achindunji.